Process 11 twin screw extruder

Manufactured by Thermo Fisher Scientific

Sourced in Germany

The Process 11 twin screw extruder is a lab-scale extrusion system designed for compounding and processing a variety of materials. It features two co-rotating screws that work together to mix, melt, and transport the material through the extruder barrel. The extruder is capable of processing thermoplastic polymers, elastomers, and other materials in a controlled and consistent manner.

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Lab products found in correlation

Varicut pelletizer, by Thermo Fisher Scientific (1 mentions)

Close spelling variants of this product

Process 11 (31 citations) Process 11 Parallel Twin-Screw Extruder (6 citations)

5 protocols using process 11 twin screw extruder

Extrusion of Drug-Carrier Formulation

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Extrusion was performed on a process 11 twin screw extruder (Thermo Scientific, Karlsruhe, Germany) with co-rotating 11 mm screws (length: 44 cm, L/D = 40) and a common screw configuration containing 2 kneading elements (arranged at 30°, 60°, and 90°). The drug and carrier in 1 : 1 ratio (w/w, 10 g : 10 g) was mixed with mortar and pestle and subsequently fed manually into the hopper of the extruder at barrel temperature 160 °C and screw speed of 120 rpm. The extrudates were solidified in liquid nitrogen and collected, then ground softly in liquid nitrogen with pestle and mortar, passed through an 80 mesh sieve, and kept in a desiccator at room temperature for further analysis.

Fan W., Zhu W., Zhang X., Xu Y, & Di L. (2019). Application of the combination of ball-milling and hot-melt extrusion in the development of an amorphous solid dispersion of a poorly water-soluble drug with high melting point. RSC Advances, 9(39), 22263-22273.

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Fabrication of PEEK/MWCNT Nanocomposite Filaments

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Multiwall
carbon nanotubes (NC7000, Nanocyl, Belgium), with an average diameter
of 9.5 nm, an average length of 1.5 μm, and a density (ρ)
of 2 g/cm³, were utilized in this study. The Arlon 1000
neat PEEK pellets were supplied by Greene Tweed (USA). A Process 11
twin screw extruder (Thermo Scientific) accompanied by a Thermo Scientific
conveyor belt and a filament spooler manufactured by Filabot were
used to extrude nanocomposite filaments with a diameter of approximately
1.75 mm to be used for FFF. The slicing software used to generate
G Code for printing was Slic3r. The FFF 3D printer used was a Hyrel
16AS printer equipped with a 400 × 300 mm print bed with a 200
°C heating capability and an HT1-450 filament head with a 0.5
mm diameter nozzle and 450 °C maximum heating capability.

Carrola M., Fallahi H., Koerner H., Pérez L.M, & Asadi A. (2023). Fundamentals of Crystalline Evolution and Properties of Carbon Nanotube-Reinforced Polyether Ether Ketone Nanocomposites in Fused Filament Fabrication. ACS Applied Materials & Interfaces, 15(18), 22506-22523.

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melt extrusion of rPP polymer

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Shredded rPP polymer was first consolidated
into pellets using melt extrusion on a Process 11 twin-screw extruder
(Thermo Scientific). The screws were fixed in an all-conveying configuration.
The feed port was set at 140 °C and the adjacent zone to 170
°C to prevent clumping of the material while feeding. The following
5 zones were fixed at 180 °C. The die (2.5 mm) was set at 175
°C. The screw speed was held constant at 100 rpm. A spooler (Filabot)
was used to collect the filament, which was subsequently pelletized
in 1.5 mm pellets (15 m/min, Varicut Pelletizer, Thermo Scientific).

Zander N.E., Park J.H., Boelter Z.R, & Gillan M.A. (2019). Recycled Cellulose Polypropylene Composite Feedstocks for Material Extrusion Additive Manufacturing. ACS Omega, 4(9), 13879-13888.

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Piperine-Loaded Solid Dispersions via Extrusion

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Piperine 10–40% w/w and Eudragit^® EPO,
Kollidon^® VA 64, or Soluplus^® (Table 1) were mixed using a V-shell blender
(Patrtreson-Kelley Twin Shell Dry Blender) for 10 minutes. The resulting
physical mixture blends were extruded using a twin-screw extruder (Process 11
Twin Screw Extruder, ThermoFisher Scientific) at the screw speed of 150 rpm, at
a temperature range of 100– 130°C. All extrudates were milled and
sieved through an ASTM #35 mesh to obtain a uniform particle size.

Ashour E.A., Majumdar S., Alsheteli A., Alshehri S., Alsulays B., Feng X., Gryczke A., Kolter K., Langley N, & Repka M.A. (2016). Hot melt extrusion as an approach to improve solubility, permeability and oral absorption of a psychoactive natural product, piperine. The Journal of Pharmacy and Pharmacology, 68(8), 989-998.

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Co-Crystallization of TPH and NAM via Twin-Screw Extrusion

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TPH and NAM in a 1:1 M ratio equivalent to 50g were weighed and blended thoroughly using a twin shell V-blender (Globe Pharma, Maxiblend®) for 15 min. Co-crystallization was carried out using a 11-mm co-rotating twin-screw extruder (Process 11 Twin Screw Extruder, Thermo Fisher Scientific) with a customized screw design of four mixing zones employing several mixing elements as shown in Fig. 1. The prepared blend was fed into the extruder hopper and operated without a die. The extrusion was performed with a 2 mm rod-shaped die when 5% (w/w) of the polymeric carriers were incorporated as the matrix material in the study. The processing temperature studied was in the range of 140–170 °C at a screw speed of 50 rpm. The compositions of different formulations F1–F7 is mentioned in Table 1.

Srinivasan P., Almutairi M., Dumpa N., Sarabu S., Bandari S., Zhang F., Ashour E, & Repka M.A. (2020). Theophylline-nicotinamide pharmaceutical co-crystals generated using hot melt extrusion technology: Impact of polymeric carriers on processability. Journal of drug delivery science and technology, 61, 102128.

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