Ondansetron

Anti-emetic or placebo administration was completed at t_1h following cisplatin treatment. Depending on treatment allocation from the experimental design, dogs received one of the following: 0.5 mg/kg ondansetron (Zofran®, GSK, Brentford, UK), 1 mg/kg maropitant (Cerenia®, Zoetis, Florham Park, NJ, USA), 0.5 mg/kg metoclopramide (Emeprid®, Ceva Santé Animale, Amersham, UK) or 0.9% saline as placebo. All treatments were made up to a standard volume of 15 mL using 0.9% saline and were administered intravenously through the second lumen of the jugular catheter at a flow rate of 1.0 mL/min.

Treatment administration protocol: Ondansetron (8 mg; GlaxoSmithKline, London, UK) was administered by i.v. 30 min before amino acid (AA) administration. The AA infusion was to prevent the development of delayed renal toxicity. The slow intravenous infusion of AA (1500 mL; Vamin 18 and Nephrotect; Fresenius Kabi, Bad Homburg, Germany) were carried out for 1.0–1.5 h, then ⁹⁰Y DOTATATE was added via an infusion pump system with a mean speed of 150 mL/h. and was continued for a approx. 20–25 min. Every subject was treated at intervals of 8–12 weeks. The treatment interval could be extended to 16 weeks in patients with longer continuing subacute hematologic adverse events (AEs). All subjects with at least two sessions of PRRT were included in the study.