Il12p35

Manufactured by Jackson ImmunoResearch

The Il12p35−/− is a laboratory product designed for research purposes. It serves as a genetic model with a targeted disruption of the Il12p35 gene. This product allows researchers to study the biological functions and implications of the Il12p35 gene in their research projects.

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Lab products found in correlation

Il 18r, by Jackson ImmunoResearch (1 mentions) Do11.10 tcr transgenic mice, by Charles River Laboratories (1 mentions) C3heb fej mice, by Taconic Biosciences (1 mentions) Wt balb c, by Jackson ImmunoResearch (1 mentions) Cd11c cre, by Jackson ImmunoResearch (1 mentions) Il1r1, by Jackson ImmunoResearch (1 mentions) C57bl 6j wt, by Jackson ImmunoResearch (1 mentions)

2 protocols using il12p35

Murine Models for Immunology Research

Cited 2 times

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C57BL/6J WT, BALB/c WT, TLR4 mutant (C3HeJ), Tlr4^−/−, Il18r^−/−, Il12p40^−/−, Tlr2^−/−, Tlr5^−/−, Il1r1^−/−, Il12p35^−/−, Langerin-eGFP-DTR, Cd11c-Cre, and B6.SJL-Ptprc^aPep3^b/BoyJ (OT-II) transgenic mice were purchased from the Jackson Laboratory. C3HeB/FeJ mice were purchased from Taconic. DO11.10 TCR transgenic mice were purchased from Charles River Laboratory. Myd88^−/−, Trif^−/− (Hise et al., 2007 (link)), Il22^−/− (Zheng et al., 2007 (link)), IIl23r^−/− (Chan et al., 2006 (link)), Unc93b1^−/− (Kim et al., 2008 (link); provided by H. Ploegh, Whitehead Institute for Biomedical Research, Cambridge, MA), Il23p19^−/− (Edgerton et al., 2009 (link); provided by M. Oukka, Center of Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA), and Il1rl1^−/− mice (Barlow et al., 2013 (link)) were previously described. All mice were kept in a pathogen-free environment and fed an OVA-free diet. GF mice were bred at the gnotobiotic Research Animal Facility at The University of Chicago. All procedures performed on the mice were in accordance with the Animal Care and Use Committee of the Children's Hospital Boston.

Yoon J., Leyva-Castillo J.M., Wang G., Galand C., Oyoshi M.K., Kumar L., Hoff S., He R., Chervonsky A., Oppenheim J.J., Kuchroo V.K., van den Brink M.R., Malefyt R.D., Tessier P.A., Fuhlbrigge R., Rosenstiel P., Terhorst C., Murphy G, & Geha R.S. (2016). IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. The Journal of Experimental Medicine, 213(10), 2147-2166.

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Immunodeficient Mouse Lineages for Research

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The study was approved by the UAB Institutional Animal Care and Use Committee. Female C3H/HeN mice aged 6-8 weeks were obtained from Charles River Breeding Laboratories (Wilmington, MA), NIH-bg-nu-xid mice 6-8 weeks old were obtained from NCI-Frederick. IL-12p35 KO and IL-12/IL-23p40 KO on a C57BL/6 background were purchased from Jackson laboratories. IL-23KO were provided by Dr. Daniel Cua (Merk Research Laboratories). IL-12p35KO, IL-12/IL-23p40KO and IL-23KO mice were backcrossed for 10-11 generations on to the C3H/HeN background by the University of Alabama at Birmingham (UAB) genetically engineered mutant mouse (GEMM) core. The C3H/HeN character was greater than 99% as detected by 2 microsatellite markers for C3H/HeN. All animals were housed in the UAB pathogen-free animal facility, fed a normal diet, and given water ad libitum. The study was approved by the UAB Institutional Animal Care and Use Committee.

Nasti T.H., Cochran J.B., Vachhani R.V., McKay K., Tsuruta Y., Athar M., Timares L, & Elmets C.A. (2016). IL-23 Inhibits Melanoma Development by Augmenting DNA Repair and Modulating T-cell Subpopulations. Journal of immunology (Baltimore, Md. : 1950), 198(2), 950-961.

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