N n diisopropylcarbodiimide dic

Manufactured by Energy Chemical

Sourced in China

N,N′-diisopropylcarbodiimide (DIC) is a carbodiimide compound commonly used as a coupling agent in organic synthesis. It is a clear, colorless liquid. DIC facilitates the formation of amide bonds between carboxylic acids and amines.

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Lab products found in correlation

1 1 carbonyl diimidazole cdi, by Energy Chemical (1 mentions) Bromoacetic acid, by Energy Chemical (1 mentions) Trifluoroacetic acid, by Energy Chemical (1 mentions) Fmoc l phe oh, by GL Biochem (1 mentions) Fmoc l ala oh, by GL Biochem (1 mentions)

2 protocols using n n diisopropylcarbodiimide dic

Synthesis and Characterization of Novel Compounds

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¹H and ¹³C nuclear magnetic resonance (NMR) spectra were recorded on a Bruker
DRX-400 MHz spectrometer (400 and 101 MHz, respectively) using CDCl₃ or DMSO-d₆ as solvents with TMS
as an internal standard. Chemical shifts were reported as d (ppm),
and spin–spin coupling constants were reported as J (Hz) values. The mass spectra (MS) were recorded on a Finnigan MAT-95
mass spectrometer. Column chromatography was performed with silica
gel (200–300 mesh).
SAHA was synthesized before. SN-38
was purchased from Shanghai Puyi Chemical Co., Ltd. Di-tert-butyl dicarbonate ((Boc)₂O), 4-dimethylaminopyridine
(DMAP), 1,1′-carbonyl-diimidazole (CDI), and N,N′-diisopropylcarbodiimide (DIC) were all
purchased from Energy Chemical Reagent Co. ( Shanghai, China). The
different amino acids were purchased from Meryer Chemical Reagent
Co. (Shanghai, China). CH₂Cl₂ was dried and
redistilled before use. All chemical reagents used were of analytical-grade
quality. Mouse plasma was taken from KM mouse (male, 6 weeks old).
Human plasma was donated by an adult man.

Liu S., Hu Z., Zhang Q., Zhu Q., Chen Y, & Lu W. (2019). Co-Prodrugs of 7-Ethyl-10-hydroxycamptothecin and Vorinostat with in Vitro Hydrolysis and Anticancer Effects. ACS Omega, 5(1), 350-357.

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Solid-Phase Peptide Synthesis of Diverse Biomolecules

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All chemicals were purchased from commercial vendors and used without further purification. Fmoc-L-Gly-OH, Fmoc-L-Leu-OH, Fmoc-L-Ile-OH, Fmoc-L-Val-OH, Fmoc-L-Lys(Boc)-OH, Fmoc-L-Lys(Alloc)-OH, Fmoc-L-Ala-OH, Fmoc-L-Cys(Trt)-OH, Fmoc-L-Gln(Trt)-OH, Fmoc-L-Asn(Trt)-OH, Fmoc-L-Glu(OtBu)-OH, Fmoc-L-Asp(OtBu)-OH, Fmoc-L-Arg(Pbf)-OH, Fmoc-L-Phe-OH, Fmoc-L-Trp(Boc)-OH, Fmoc-His(Boc)-OH, Fmoc-L-Ser(tBu)-OH, Fmoc-L-Thr(tBu)-OH, Fmoc-L-Tyr(tBu)-OH, Fmoc-L-Pro-OH, Boc-L-Asp(OtBu)-OH, and Fmoc-L-Met-OH were purchased from GL Biochem. Fmoc-Rink amide resin was purchased from Tjhecheng. Bromoacetic acid, [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, N,N′-diisopropylcarbodiimide (DIC), ethyl cyanoglyoxylate-2-oxime (Oxyma), N,N-dimethylformamide (DMF), dichloromethane (DCM), diethyl ether, trifluoroacetic acid, triisoproprylsilane, 4-methyl pepiridine and HPLC-grade acetonitrile were obtained from Energy Chemical.

Bi W., Tang K., Chen G., Xie Y., Polizzi N.F., DeGrado W.F., Yuan S, & Dang B. (2024). An enhanced broad-spectrum peptide inhibits Omicron variants in vivo. Cell Reports Medicine, 5(2), 101418.

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