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Benzisoxazole

Manufactured by Thermo Fisher Scientific

Benzisoxazole is a heterocyclic organic compound with the chemical formula C8H7NO. It consists of a benzene ring fused to an isoxazole ring. Benzisoxazole serves as a core structure in various pharmaceutical and agrochemical compounds, but a detailed description of its specific functions or intended uses cannot be provided in an unbiased and factual manner within the constraints of this request.

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2 protocols using benzisoxazole

1

Synthesis of Benzisoxazole Derivatives

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5-NitroBenzisoxazole and 5-bromoBenzisoxazole were purchased from Ark Pharm. 5-bromoBenzisoxazole was recrystallized from methanol. Benzisoxazole and hydroxylamine hydrochloride were purchased from Alfa Aesar. 2-Hydroxy-1-benzaldehyde, triphenylphosphine, and DDQ were from Sigma-Aldrich. CTAC, sodium laurate, and dodecyl phosphate were purchased from TCI. Dodecyl phosphate was recrystallized twice from isoctanol. Naphthisoxazole was prepared in two steps from 2-hydroxy-1-benzaldehyde as described below, using slightly modified literature procedures.[16 ,17 ]
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2

Synthesis and Characterization of Benzisoxazole Derivatives

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5-nitroBenzisoxazole, 6-nitroBenzisoxazole, 5-bromoBenzisoxazole, and 6-bromoBenzisoxazole were from Ark Pharm (Libertyville, IL). Benzisoxazole, 4,6-dichlorosalicylaldehyde and hydroxylamine were from Alfa Aesar. Triphenylphosphine and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) were from Sigma-Aldrich. Buffers and salts were from Alfa Aesar or Sigma-Aldrich. UV spectra and spectrophotometric kinetic assays were recorded using a Varian Cary 50 UV/visible spectrophotometer.
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