A micro hot rod phantom filled with 18F− was scanned with both the prototype PET scanner and Siemens Inveon D-PET scanner (2 (link)). The rod diameters of the phantom are 0.35, 0.40, 0.45, 0.50, 0.60 and 0.75 mm, and the rod to rod distance is twice the rod diameter. For the prototype scanner, the scan time was 240 min and the activity at the start was 4.2 MBq. In total 38 million counts were acquired. For the D-PET scanner, the scan time was 30 min and the starting activity was 4.4 MBq. In total 380 million counts were acquired. A longer acquisition time was used for the prototype scanner as it only has one detector ring (therefore lower sensitivity) and sufficient counts are required to reconstruct at the highest possible resolution. The dataset from the prototype scanner was reconstructed by a 3D ML-EM algorithm with 700 iterations. The D-PET scanner images were reconstructed by 3D ordered subset expectation maximization/maximum a posteriori (OSEM/MAP) with the default reconstruction parameters (2 OSEM iterations and 18 MAP iterations) suggested by the vendor.
Inveon dpet scanner
Manufactured by Siemens
Sourced in United States
The Inveon DPET scanner is a preclinical PET imaging system designed for small animal research. It provides high-resolution, quantitative imaging of small laboratory animals such as mice and rats. The system is capable of acquiring dynamic PET data, allowing for the study of tracer kinetics and physiological processes in living subjects.
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5 protocols using inveon dpet scanner
1
Comparative Evaluation of PET Scanners
2
PET/CT Imaging of SqNOTA and 64Cu-SqNOTA-SqGem NPs in Mice
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Briefly, two mice were placed side by side, anesthetized with isofluorane, and catheterized to ensure proper tail vein injection. Bolus injections of either SqNOTA or 64Cu-SqNOTA-SqGem NPs were administered as PET scans on a Inveon DPET scanner (Siemens) were initiated. Mice were imaged at 0 h and 4 h for 30 minutes on PET. Immediately following each PET scan, mice were imaged on a Siemens Inveon CT. Following the 4 h scans, mice were euthanized by injection of Euthasol and perfused with Dulbecco's Modification of Eagle's Medium (DMEM). Organs of interest were harvested and weighed, and radioactivity was measured by Wizard 1470 Automatic Gamma Counter (PerkinElmer), presented as a percent injected dose per gram organ (%ID/g). First 30 min PET images were segmented to 13 frames (15s4f, 30s2f, 60s3f, 300s3f, 600s1f) and reconstructed with maximum a posteriori algorithm. Blood radioactivity was calculated by drawing ROI of left ventricle of heart with PET/CT contrast normalized to 0 and 25 injected dose per cubic centimeter (%ID/cc) by a single observer with Inveon Research Workplace software (Siemens Preclinical Solutions). Using the same software, time activity curves (TACs) were obtained with region-of-interest (ROI) analysis and expressed as %ID/cc.
3
In Vivo PET/CT Imaging of Radiolabeled Peptides
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For imaging studies, [64Cu]1 and [64Cu]2 (7.77–8.88 MBq) in PBS (100 μL, pH 7.2) were injected i.v. via a catheter into the tail vein of mice (n = 3/radiolabeled peptide) anesthetized with 2–3% isoflurane in medical grade oxygen. Animals were imaged in a prone position two at a time side by side. PET/CT scans were acquired using Inveon scanners (Inveon DPET scanner and Inveon SPECT/CT scanner, Siemens Medical Solutions, Knoxville, TN, USA; PET scans: a static 15 min scan at 4 h p.i., static 30 min scans at 24 and 48 h p.i., and a static 1 h scan at 72 h p.i.) and analyzed as previously described using the Inveon Research Workplace software (Siemens) [42 (link),44 (link)].
4
PET Imaging of Cancer Aptamers
5
PET Imaging of Tumor-Bearing Mice
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Tumor-bearing Nu/Nu female mice (n = 3 for each probe) were anesthetized using 2% isoflurane in oxygen and injected with ~100 µCi (~0.15 nmol) of the tracers described above via the tail vein. Five-minute static PET scans were acquired on an Inveon PET-CT or Inveon D-PET scanner (Siemens Healthcare, Malvern PA). Images were reconstructed by a two-dimensional ordered expectation maximum subset algorithm and calibrated as described below. ROIs were drawn over the tumor on decay-corrected whole-body images using Inveon Research Workplace (IRW) software (Siemens) or ASIPro VM software (Siemens). ROIs were converted to counts g−1 min−1, and %ID g−1 values were determined assuming a tissue density of 1 g ml−1.
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