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Stimuplex a

Manufactured by B. Braun
Sourced in Germany, United States

The Stimuplex A is a medical device used for nerve stimulation during regional anesthesia procedures. It features a high-quality insulated needle designed for precise nerve location.

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9 protocols using stimuplex a

1

Ultrasound-Guided Thoracic Paravertebral Blockade

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In the anesthesia preparation room, patients were monitored according to ASA standards and than sedated with midazolam (0.04 mg/Kg). An experienced anesthesiologist performed unilateral, single-injection TPVB at T5 level of the operation side with ultrasound guided (USG) in lateral position before anesthesia induction. A low-frequency convex array USG probe (2 to 5 MHz; Konica Minolta Sonimage HS1,Shanghai,China.) was placed longitudinally 2.5 cm lateral to the tip of spinous process to identify the hyperechoic image of pleura between shadows of consecutive transverse processes. Peripheral block needle (22 gauge; Stimuplex® A; B Braun, Melsungen, Germany) was advanced to the pleura using in-plane technique. After negative aspiration, downward displacement of the pleura by administration of saline was visualized on USG and then block was achieved with 20 ml of 0.375% ropivacaine. Local anesthetic distribution above pleura was checked by moving the probe up and down to confirm success of block (Fig. 1).

Paramidsagittal ultrasonography of T5 transverse process and thoracic paravertebral block performing figures. (A) Sonographic anatomy, (B) Needle direction, (C) Craniocaudal spread of local anesthetic

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2

Ultrasound-Guided Femoral Nerve Blockade

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All femoral nerve blocks were performed with ultrasound guidance by anesthesiologists experienced in administering regional anesthesia. All blocks were performed in the preoperative area prior to induction of general anesthesia. Using the same previously described single-shot technique [18 (link)], the femoral nerve was located distal to the inguinal ligament under ultrasound guidance in each patient. Following sterile skin preparation, a 22- or 21-gauge needle (Stimuplex A, B. Braun Medical Inc., PA, USA) was used to administer 25–30 mL of either 0.5% or 0.1–0.125% bupivacaine with epinephrine 1:200,000 lateral to the femoral nerve in an in-plane technique. Muscle stimulators were not used. Normal saline was used for bupivacaine dilution. In addition to observing perineural spread of local anesthetic, success of the block was determined by the anesthesia team assessing tactile sensation along with the femoral nerve distribution.
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3

Ultrasound-Guided Erector Spinae Plane Block

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The appropriate level was determined by palpating the inferior angle of the scapula to identify the approximate level of the thoracic (T) 7 level. The T5–6 level could then be ascertained relative to the T7 level by scanning in the cranial direction with ultrasound visualization. A left-sided ESP block at the T5–6 level was performed under ultrasound guidance (Sonosite S-Nerve Ultrasound System fitted with an L38 £ 10- to 5-MHz transducer; Sonosite, Inc., Bothell, WA, USA) with a 22-gauge, 2-in. stimulating needle (Stimuplex® A; B. Braun Medical Inc., Bethlehem, PA, USA) using an in-plane technique with the needle advancing in a cranial-to-caudal direction through the erector spinae muscle until the transverse process was contacted. A total of 20 mL of 0.25% bupivacaine was administered between the transverse process and the erector spinae muscle (Figure 2). In the surgical infiltration group, 30 mL of 0.25% bupivacaine was injected into the implantation and tunneling sites before the incision. The patients in the ESP group did not receive any additional local anesthetics from the operating electrophysiologist team. Patients were administered an intravenous propofol infusion with intermittent boluses of intravenous midazolam and/or fentanyl as needed.
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4

Ultrasound-Guided Brachial Plexus Blocks

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The patients were positioned according to their determined brachial plexus block type. A General Electric (GE) LOGIQ e model (GE Medical Systems, Phoenix, AZ, USA) was used as USG. The Linear Multifrequency 12L probe was passed through a sterile camera sheath and made suitable for use in the surgical field. Stimuplex A® (B. Braun Aesculap, Hongo, Bunkyo-ku, Japan) 21G was used as the needle. A needle of 100 mm in length for supraclavicular and infraclavicular block and 50 mm in length for interscalene block was preferred. The entry site of the peripheral nerve block needle was sterilized with an antiseptic solution containing 10% povidone-iodine. After the preparation the patient was informed, and 4cc 2% lidocaine hydrochloride was injected into the entry site to provide local anesthesia. The USG probe was positioned according to the block type, and the in-plane technique was always used during application. A local anesthetic was injected at the required dose and concentration from the appropriate brachial plexus region according to the decided upper-extremity block.
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5

In-Vitro Pressure Sensor Evaluation

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A polysulphone fluid pressure sensor (PendoTech, New Jersey) with a measurement range between 48 kPa (7 psi) and 517 kPa (75 psi) was connected in-line between the side tubing of a 22g, 50 mm needle (Stimuplex A, B.Braun, Melsungen AG) and a 30 ml syringe of saline (9 mg.ml -1 ) held within a programmable electro-mechanical infusion pump (PHD Ultra, Harvard Apparatus, Holliston, MA). Fluid pressure was recorded continuously at a frequency of 0.5 Hz using the same digital biological manometer (Pressure-MAT, PendoTech, New Jersey) used in clinical trials 11; 12 . The infusion pump was programmed to deliver 0.5 ml 22 because this volume is easily recognisable using in-plane and out-of-plane approaches using micro-ultrasound 20 . The 1, 6 and 12 ml.min -1 injection rates replicated the rates used in previous animal 7; 10; 23 and clinical 11; 12 studies, and were below the 15 ml.min -1 threshold infusion rate identified by Patil et al 24 . Infusion rates > 15 ml.min -1 are associated with nonlaminar flow and a high rate of false positive pressure measurements 24 . Opening injection pressure was defined as the peak pressure generated following injection.
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6

Erector Spinae Plane Block Technique

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Patients were placed on their left side so that their right side was superior. The linear ultrasound transducer was placed in a longitudinal parasagittal orientation 2.5–3 cm lateral to the T9 spinous process. The erector spinae muscles were identified superficial to the tip of the T9 transverse process. A 21G 10-cm needle (Stimuplex A, B Braun, Melsungen, Germany) was inserted using an out-of-plane approach. The tip of the needle was placed into the fascial plane on the deep (anterior) aspect of the erector spinae muscle. The location of the needle tip was confirmed by visible fluid spread lifting the erector spinae muscle off the bony shadow of the transverse process on ultrasonographic imaging. A volume of 20 mL of LA mixture was injected. Due to reports that ESPB blocks visceral pain especially that of peritoneal distention, and as at least one trocar is placed in the midline, the same procedure was repeated for the opposite side. Probe position and sonographic view are shown in Figure 2.
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7

Ultrasound-Guided Rectus Abdominis Plane Block

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Blocks were performed in the supine position using a high-frequency linear transducer with the in-plane technique. The transducer was placed immediately below the costal margin on the oblique plane. The rectus abdominis, transverse abdominis, and internal oblique and external oblique muscles were identified. A 21G 10-cm needle (Stimuplex A, B Braun, Melsungen, Germany) was inserted using an in-plane approach from medially to laterally. 20 mL of LA was applied between the fascia immediately above the rectus abdominis muscle. The same procedure was applied bilaterally. The same volume and mixture of LA was performed, as described previously for ESPB. Probe position and sonographic view are shown in Figure 3.
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8

Interscalene Brachial Plexus Block for Shoulder Surgery

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Patients in the ISB group received the block before the induction of general anesthesia in the operating room. After supine positioning with head rotation to the other side, ISB was performed with ultrasound and nerve stimulation. The brachial plexus was identified using a nerve stimulator (Stimuplex-S, B. Braun Melsungen AG, Melsungen, Germany) connected to the proximal end of the metal inner needle of a plastic cannula (Stimuplex-A, 25-G B. Braun Melsungen). The initial current output of the nerve stimulator was 0.7 mA. A linear high frequency 6-13 MHz ultrasound probe (Sonosite M-turbo, SonoSite, Inc., Bothell, WA, USA) was used. Upon contraction of the triceps muscle, the C5-6 nerve root or superior trunk was found, and 10 ml of 0.25% ropivacaine with 200 mcg of epinephrine was injected. Twelve hours after the operation, a fentanyl patch (12 mcg/hr) was applied to the patients.
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9

Erector Spinae Plane Block for Postoperative Analgesia

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All blocks were performed immediately after surgery in the lateral position. Local anesthetic for skin or subcutaneous tissue was not used as the spinal anesthesia effect had not worn off. ESPB was performed under sterile conditions using ultrasound guidance of a high frequency linear transducer. T11 vertebra was identified, and the transducer was placed 3 cm lateral to the spinous process in the parasagittal plane. Following identification of erector spinae muscles and the transverse process a 21G 10-cm needle (Stimuplex A, B Braun, Melsungen, Germany) was inserted using an out-of-plane approach. The tip of the needle was placed into the fascial plane on the deep (anterior) aspect of erector spinae muscle. The location of the needle tip was confirmed by visible fluid spread lifting erector spinae muscle off the bony shadow of the transverse process on ultrasonographic imaging. A total of 20 mL consisting of 10 ml bupivacaine 0.5%, 5 mL lidocaine 2% and 5 mL normal saline was applied to the interfacial plane. The procedure was repeated for the opposite side.
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