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Xience pro

Manufactured by Abbott
Sourced in United States

The Xience Pro is a medical device designed for use in cardiac catheterization procedures. It is a coronary stent system that is used to open blocked or narrowed arteries in the heart, improving blood flow. The device is made of a metal alloy and is delivered to the treatment site using a catheter.

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2 protocols using xience pro

1

Coating Deployment and Drug Delivery

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Two different 3×15 mm drug eluting stents (DES) were used in this study: the Xience Pro™ ® that elutes everolimus from a strut adherent durable fluoropolymer coating (Xience Pro Abbott Vascular, Santa Clara, CA) and MiStent which incorporates crystalline sirolimus (median crystal size = 2.5 μm) within a deployable absorbable PLGA coating (Micell Technologies, Durham, NC). Nominal drug loads were 135 μg for the MiStent® and 74 μg for the Xience. Previously we had shown that the MiStent sustains higher drug loads in the tissue compared to conformal coated stents with similar drug loads[3 (link)]. Based on histological evidence of coating deployment, we hypothesized that the deployed coating carries crystalline particles along with it. This was never proven, however, and left open the possibility that polymer coating deploys further from struts than drug particles.
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2

Evaluation of Stent Implantation in Patients with Stent Failure

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All interventions were performed using standard techniques. Predilation, postdilation, and use of intracoronary imaging (intravascular ultrasound (IVUS) or optical coherence tomography (OCT)) were left to the operator's discretion, as well as the decision to implant a further stent in patients with ESV-confirmed SF. ESV system utilization was mandatory after stent implantation and after postdilation (if it was performed). The following DES were implanted: Xience V or Xience Prime or Xience PRO (Abbott Vascular, Santa Clara, CA, USA), Promus Element or Promus Premier (Boston Scientific, Natick, MA, USA), Biomatrix Flex (Biosensors Europe SA, Morges, Switzerland), and Cre8 (CID and Alvimedica. S.P.A., Saluggia, Italy). After the procedure, all patients were advised to continue dual antiplatelet therapy (DAPT) with aspirin and P2Y12 inhibitor months after 2nd-generation DES implantation in patients with SF-predisposing factors. Secondary endpoints were: (1) any component of the primary endpoint; (2) definite and probable stent thrombosis (ST), and (3) target vessel revascularization (TVR). Finally, as a preliminary analysis, we compared the occurrence of the primary endpoint in patients with SF III-IV stratified according to the implantation (or not) of a further stent. All endpoints were adjudicated by an independent reviewer (R.P.), who was unaware of any data.
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