Biograph 40 system

Manufactured by Siemens

Sourced in United States, Germany

The Biograph 40 system is a positron emission tomography (PET) scanner designed for medical imaging. It is a compact and versatile system that produces high-quality images for the diagnosis and monitoring of various medical conditions. The core function of the Biograph 40 system is to detect and measure the distribution of a radioactive tracer within the body, providing valuable information to healthcare professionals.

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Biograph 40

2 protocols using biograph 40 system

PET/CT Imaging Protocol for Oncology

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PET/CT was performed on a Biograph 40 system (Siemens Healthcare, Knoxville, TN, USA). Standard AC of the acquired PET data was performed using a μ-map generated from CT information and reconstructed with 3D-OSEM (Ordered Subset Estimation Maximization) with 3 iterations, 21 subsets and post-Gaussian filter of 4 mm. The CT scan was performed at 120 kVp, 111 effective mAs and at pitch of 1, and images were reconstructed at a slice thickness of 4mm. The CT-AC scan duration was approximately 1 minute from ears to mid-thigh. Instructions were given to the patient to hold a relaxed breathing position during the CT scan over the chest.

Lau J., Laforest R., Sotoudeh H., Nie X., Sharma S., McConathy J., Novak E., Priatna A., Gropler R, & Woodard P. (2015). Evaluation of Attenuation Correction in Cardiac PET using PET/MR. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 24(3), 839-846.

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Ga-PSMA PET/CT Imaging Protocol

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Patients underwent ⁶⁸Ga-PSMA PET imaging with a Biograph 40 system (Siemens Medical Solutions, Erlangen, Germany). The mean injection activity of ⁶⁸Ga-PSMA PET was 139.72 ± 25.00 MBq. Details are given in the supplementary information. All ⁶⁸Ga-PSMA PET/CT images were evaluated at a single center (Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China). The ⁶⁸Ga-PSMA PET/CT scans were evaluated by two board-certified nuclear medicine experts (Z.Q. and F.K.) with more than 10 years of experience in reading PET images and one board-certified radiation oncologist (J.W.). The scans were evaluated using a Siemens MIWP workstation (Syngo MIWP; Siemens Medical Solutions, Erlangen, Germany) according to the Joint European Association of Nuclear Medicine and Society of Nuclear Medicine and Molecular Imaging procedure guidelines (version 1.0) 18 (link), 19 (link). The zonal anatomy analysis was based on a method from a previous study 20 (link).

Jiao J., Kang F., Zhang J., Quan Z., Wen W., Zhao X., Ma S., Wu P., Yang F., Guo W., Yang X., Yuan J., Shi Y., Wang J, & Qin W. (2021). Establishment and prospective validation of an SUVmax cutoff value to discriminate clinically significant prostate cancer from benign prostate diseases in patients with suspected prostate cancer by 68Ga-PSMA PET/CT: a real-world study. Theranostics, 11(17), 8396-8411.

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