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β funaltrexamine

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β-funaltrexamine is a laboratory chemical reagent used in research applications. It functions as a selective antagonist for the μ-opioid receptor.

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Lab products found in correlation

Naltrindole, by Merck Group (3 mentions) Nor binaltorphimine, by Merck Group (2 mentions) Naloxone methiodide, by Merck Group (1 mentions) Loperamide hcl, by Merck Group (1 mentions) Diprotin a, by Merck Group (1 mentions) Phenyl n tert butylnitrone, by Merck Group (1 mentions) Endomorphin 1, by Merck Group (1 mentions) Dimethyl sulfoxide (dmso), by Thermo Fisher Scientific (1 mentions) Acetic acid, by Thermo Fisher Scientific (1 mentions) Caffeine, by Merck Group (1 mentions) Glibenclamide, by Merck Group (1 mentions) Haloperidol, by Merck Group (1 mentions) Phorbol 12 myristate 13 acetate, by Merck Group (1 mentions) Pindolol, by Merck Group (1 mentions) Apamin, by Merck Group (1 mentions) Clonidine, by Merck Group (1 mentions) Yohimbine, by Merck Group (1 mentions) Charybdotoxin, by Merck Group (1 mentions) Prazosin, by Merck Group (1 mentions) Bradykinin, by Bio-Techne (1 mentions)

Spelling variants of this product

β-funaltrexamine hydrochloride (2 citations)

4 protocols using β funaltrexamine

1

Opioid Receptor Pharmacology Protocol

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The compounds used were: loperamide HCl (Sigma, St. Louis, MO), oxymorphindole HCl14 (link), β-funaltrexamine18 (link), naltrindole19 (link), and naloxone methiodide (Sigma, St. Louis, MO). Stock solutions were prepared with 5% Cremophor EL and 5% DMSO in H2O. All drugs were diluted to testing concentrations with 0.9% sterile saline (or aCSF for electrophysiology) such that final Cremophor and DMSO concentrations were <1%; the topical vehicle was further diluted 1:1 with 95% ethanol. The routes and volumes of administration were: intrathecal (i.t.), 5 μL; intraplantar (i.pl.), 30 μL; subcutaneous (s.c.), 10 μL per gram; and topical, 20 μL. Intrathecal injections were performed as previously described20 (link). For i.pl. injections and topical administration, animals were lightly anesthetized with 2.5% isoflurane and the drugs were administered to the left hindpaw.
Bruce D.J., Peterson C.D., Kitto K.F., Akgün E., Lazzaroni S., Portoghese P.S., Fairbanks C.A, & Wilcox G.L. (2019). The combination of a delta-opioid receptor agonist and loperamide produces peripherally-mediated analgesic synergy in mice. Anesthesiology, 131(3), 649-663.
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2

Neuroprotective Agents in Research

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Endomorphin-2, Endomorphin-1, β-funaltrexamine (β-FNA, antagonist for mu-opioid receptor), phenyl N-tert-butylnitrone (PBN, scavenger for reactive oxygen species) and diprotin A (inhibitor of dipeptidylpeptidase IV) were purchased from Sigma-Aldrich.
Yang Y., Zhang Y.G., Lin G.A., Xie H.Q., Pan H.T., Huang B.Q., Liu J.D., Liu H., Zhang N., Li L, & Chen J.H. (2014). Spinal Changes of a Newly Isolated Neuropeptide Endomorphin-2 Concomitant with Vincristine-Induced Allodynia. PLoS ONE, 9(2), e89583.
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3

Pharmacological Agents for Cell Studies

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The drugs apamin, charybdotoxin, tetraethylammonium chloride, atropine, haloperidol, pindolol, yohimbine, prazosin, phenylpherine, clonidine, caffeine, glibenclamide, β-funaltrexamine, naltrindole, nor-binaltorphimine, all purchased from Sigma Aldrich (U.S.A.) and bradykinin (Tocris Bioscience, U.K.), were prepared at the desired dose by dissolving them in distilled water (dH2O). Phorbol 12-myristate 13-acetate (Sigma Aldrich, USA) was dissolved in PBS solution. Acetic acid and dimethyl sulfoxide (DMSO) were purchased from Fisher Scientific (U.K.).
Zakaria Z.A., Sani M.H., Cheema M.S., Kader A.A., Kek T.L, & Salleh M.Z. (2014). Antinociceptive activity of methanolic extract of Muntingia calabura leaves: further elucidation of the possible mechanisms. BMC Complementary and Alternative Medicine, 14, 63.
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4

Pharmacological Intervention in Pain Study

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Tetraethylammonium, glibenclamide, apamin, and charybdotoxin were purchased from Tocris (Bristol, UK). DMSO and Tween 20 were purchased from Sigma-Aldrich (St. Louis, MO, USA). Naloxone hydrochloride, β-funaltrexamine, naltrindole, nor-binaltorphimine, DMSO, and Tween 20 were bought from Sigma-Aldrich (St. Louis, MO, USA). Morphine sulphate was purchased from Lipomed (Cambridge, MA, USA). All drugs were dissolved in 0.9% NaCl. The vehicle consisted of DMSO, Tween 20, and 0.9% NaCl at a ratio of 5:5:90. All treatments were administered either intraperitoneally or subcutaneously at a volume of 10 mL/kg of body weight. Intraperitoneal injection was administered in the intraperitoneal cavity and subcutaneous administrations were made into the loose skin over the interscapular area.
Gopalsamy B., Chia J.S., Farouk A.A., Sulaiman M.R, & Perimal E.K. (2020). Zerumbone-Induced Analgesia Modulated via Potassium Channels and Opioid Receptors in Chronic Constriction Injury-Induced Neuropathic Pain. Molecules, 25(17), 3880.
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