Tecnai 12 twin microscope

Manufactured by Thermo Fisher Scientific

The Tecnai 12 TWIN microscope is a transmission electron microscope (TEM) designed for high-resolution imaging and analysis of nanoscale structures. It provides a maximum accelerating voltage of 120 kV and offers a resolution of up to 0.34 nm. The microscope is equipped with a LaB6 electron source and features user-friendly software for instrument control and data acquisition.

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Tecnai 12 (254 citations) Tecnai 12 microscope (30 citations) Tecnai 12 Spirit Bio TWIN transmission electron microscope (18 citations) Tecnai 12 TWIN Transmission Electron Microscope (5 citations) Tecnai G2 12 Bio Twin electron microscope (3 citations) Tecnai G2 Spirit Twin 12 microscope (3 citations) Tecnai-12 TWIN electron microscope (3 citations)

3 protocols using tecnai 12 twin microscope

TEM Imaging of Nanoparticle Samples

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The TEM imaging was carried out on a FEI Tecnai 12 TWIN microscope (Hillsboro, OR) at 100 kV. The samples were prepared by using the following protocol: A 100 μM solution (5 μL) was initially deposited on a copper grid with carbon film (CF400-Cu, Election Microscopy Sciences, Hatfield, PA). Excess amount of the solution was removed by filter paper. The samples were then negatively stained with 2% uranyl acetate, and the excess uranyl acetate solution was removed by filter paper after 30 seconds. The samples were dried under room temperature for at least 3 hours before they were used for imaging.

Wang W., Sreekumar P.G., Valluripalli V., Shi P., Wang J., Lin Y.A., Cui H., Kannan R., Hinton D.R, & MacKay J.A. (2014). Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells. Journal of controlled release : official journal of the Controlled Release Society, 191, 4-14.

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Structural and Colloidal Characterization of Magnetite Nanoparticles

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Transmission electron microscopy (TEM) images were acquired on a 120 kV, FEI Tecnai 12 Twin Microscope at 100 kV Voltage. TEM images were acquired for Fe₃O₄ NPs in Hexanes, and Fe₃O₄-PEG12, Fe3O4-PEG3000 NPs in PBS. Dynamic light scattering and zeta potential measurements were made using Zetasizer Nano S- Malvern Panalytical to find approximate size of Nanoparticles and their change in size and overall charge upon pegylation with PEG12 and PEG3000 chains.

Goyal M.M., Zhou N.J., Vincent P.F., Hoffman E.S., Goel S., Wang C, & Sun D.Q. (2022). Rationally Designed Magnetic Nanoparticles for Cochlear Drug Delivery: Synthesis, Characterization, and In Vitro Biocompatibility in a Murine Model. Otology & Neurotology Open, 2(3), e013.

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TEM imaging of nanoparticle samples

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The TEM imaging was carried out on a FEI Tecnai 12 TWIN microscope (Hillsboro, OR) at 100 kV. Briefly, a 100 μM solution (5 μL) was initially deposited on a copper grid with carbon film (CF400-Cu, Election Microscopy Sciences, Hatfield, PA). After removing the excess amount of solution with filter paper, the samples were negatively stained with 2 % uranyl acetate, followed by removing excess uranyl acetate after 30 s. The samples were then dried under room temperature for at least 3 h before use in imaging.

Wang W., Despanie J., Shi P., Edman-Woolcott M.C., Lin Y.A., Cui H., Heur J.M., Fini M.E., Hamm-Alvarez S.F, & MacKay J.A. (2014). Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. Journal of materials chemistry. B, Materials for biology and medicine, 2(46), 8131-8141.

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