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Temsirolimus

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Temsirolimus is a compound used in laboratory research. It is an mTOR inhibitor and functions to suppress the mammalian target of rapamycin (mTOR) pathway.

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Lab products found in correlation

Carboplatin, by MedChemExpress (1 mentions) Selumetinib, by MedChemExpress (1 mentions) Irinotecan, by MedChemExpress (1 mentions)

2 protocols using temsirolimus

1

Drug Formulation and Dosing Protocol

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Selumetinib, carboplatin, irinotecan, and temsirolimus were purchased from MedChem Express. JQ1 was kindly provided by Dr. James Bradner (Dana-Farber Cancer Institute, Boston, MA, USA). Drugs were resuspended in N-Methyl-2-pyrrolidone (NMP) to create a stock solution (Sigma Aldrich) and diluted in PTD buffer (30 % PEG-400; 5 % Tween 80; 65 % Dextrose water, D5W, Sigma Aldrich) before drug dosing.
Dela Cruz F.S., Diolaiti D., Turk A.T., Rainey A.R., Ambesi-Impiombato A., Andrews S.J., Mansukhani M.M., Nagy P.L., Alvarez M.J., Califano A., Forouhar F., Modzelewski B., Mitchell C.M., Yamashiro D.J., Marks L.J., Bender J.L, & Kung A.L. (2016). A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. Genome Medicine, 8, 116.
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2

Synthesis and Characterization of MP1

Cited 2 times
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MP1 (purity: ≥ 98%) was synthesized by Dr. Rongshi Li, a co-author in this manuscript. The toxicity, pharmacokinetic (PK), and brain-penetrance properties of this compound have been reported by us [19 (link), 20 (link)]. Temsirolimus was purchased from MedChemExpress LLC. These inhibitors were dissolved in dimethyl-sulfoxide (DMSO) at 1- or 10-mM concentrations and stored at -20 °C. In each experiment, an equivalent amount of DMSO for the highest drug concentration was used as solvent control.
Coulter D.W., Chhonker Y.S., Kumar D., Kesherwani V., Aldhafiri W.N., McIntyre E.M., Alexander G., Ray S., Joshi S.S., Li R., Murry D.J, & Chaturvedi N.K. (2024). Marinopyrrole derivative MP1 as a novel anti-cancer agent in group 3 MYC-amplified Medulloblastoma. Journal of Experimental & Clinical Cancer Research : CR, 43, 18.
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