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Soybean phosphatidylcholine

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Soybean phosphatidylcholine is a naturally occurring phospholipid compound derived from soybeans. It is a key component of cell membranes and plays a crucial role in various biological processes.

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Lab products found in correlation

Sodium deoxycholate, by Merck Group (3 mentions) Cholesterol, by Merck Group (2 mentions) Span 60, by Merck Group (2 mentions) Bile salt sodium deoxycholate, by Merck Group (1 mentions) Methanol, by Merck Group (1 mentions) Acetonitrile, by Merck Group (1 mentions) Chloroform, by Merck Group (1 mentions) Limonene, by Merck Group (1 mentions) Rhodamine b, by Merck Group (1 mentions) Human tf iron free, by Merck Group (1 mentions) L α phosphatidylethanolamine, by Merck Group (1 mentions) Stearic acid, by Merck Group (1 mentions) Tween 80, by Merck Group (1 mentions) Triethylamine, by Merck Group (1 mentions) Dox hcl, by Merck Group (1 mentions) Dimethyldioctadecylammonium bromide, by Merck Group (1 mentions) Fetal bovine serum (fbs), by Merck Group (1 mentions) Hydroxypropyl methylcellulose, by Merck Group (1 mentions) Dialysis bag, by Merck Group (1 mentions) Hydrogenated soybean phosphatidylcholine, by Merck Group (1 mentions)

Spelling variants of this product

Phosphatidylcholine (107 citations) L-α-phosphatidylcholine from soybean (4 citations) L-α-phosphatidylcholine from soybean type II-S (2 citations) Soybean phosphatidylcholine (PC) (2 citations) L-α-phosphatidylcholine (PC) from soybean (2 citations) Soybean L-α-phosphatidylcholine (2 citations) Hydrogenated soybean phosphatidylcholine (2 citations) Soybean phosphatidylcholine (SPC), (2 citations)

8 protocols using soybean phosphatidylcholine

1

Pneumococcal Conjugate Vaccine Formulation

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Low molecular weight chitosan (C8H15NO6)n powder with 75% degree of deacetylation and soybean phosphatidylcholine were purchased from Sigma-Aldrich, USA. The Quil-A saponin adjuvant was a gift from Dr. Erik B. Lindblad and Brenntag Biosector, Denmark. The 13-valent pneumococcal conjugate vaccine (PCV13; Prevnar®; Pfizer Inc.) as a PCV antigen model was commercially acquired. The PCV13 contains the capsular polysaccharide antigens of Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F which individually conjugated to the nontoxic diphtheria toxin mutant CRM197.
Haryono A., Salsabila K., Restu W.K., Harmami S.B, & Safari D. (2017). Effect of Chitosan and Liposome Nanoparticles as Adjuvant Codelivery on the Immunoglobulin G Subclass Distribution in a Mouse Model. Journal of Immunology Research, 2017, 9125048.
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2

Liposomal Encapsulation of Rhodamine B

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LX received as a gift from Delta Pharma, 10th of Ramadan City, Cairo, Egypt. Bile salt sodium deoxycholate (SDC), soybean phosphatidyl choline (SPC), limonene, chloroform, methanol, acetonitrile (HPLC grade) and rhodamine B were bought from Sigma Chemical Company. Ethanol (95%) was provided from El-Nasr Pharmaceutical Chemicals Co. (Cairo, Egypt). All other chemicals and solvents were of analytical grade and were used as received.
Ahmed S., Kassem M.A, & Sayed S. (2020). Bilosomes as Promising Nanovesicular Carriers for Improved Transdermal Delivery: Construction, in vitro Optimization, ex vivo Permeation and in vivo Evaluation. International Journal of Nanomedicine, 15, 9783-9798.
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3

Lipid-Based Nanocarrier Synthesis and Characterization

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Maleimide-PEG2000-COOH was purchased from Shanghai Yare Biotech Inc, (Shanghai, People’s Republic of China). Human Tf (iron-free) and L-α-phosphatidylethanolamine (PE) were purchased from Sigma-Aldrich Corp (St Louis, MO, USA). Tf-PEG-PE was synthesized by our group. 3-[4,5-dimehyl-2-thiazolyl]-2,5-diphenyl-2H-tetrazolium bromide (MTT), DOX·HCl, stearic acid, dimethyldiocta-decylammonium bromide (DDAB), soybean phosphatidylcholine, triethylamine (TEA), and Tween® 80 were purchased from Sigma-Aldrich. Precirol® ATO 5 was generously provided by Gattefossé (St Priest, France). Injectable soya lecithin was obtained from Shanghai Taiwei Pharmaceutical Co, Ltd., (Shanghai, People’s Republic of China). Enhanced green fluorescence protein plasmid (pEGFP)-N1 was provided by Shandong University (Shandong, People’s Republic of China). Quant-iT™ PicoGreen® double-stranded (ds) DNA quantitation reagent was obtained from Invitrogen by Life Technologies (Carlsbad, CA, USA). All other chemicals were of analytical grade or higher.
Han Y., Zhang Y., Li D., Chen Y., Sun J, & Kong F. (2014). Transferrin-modified nanostructured lipid carriers as multifunctional nanomedicine for codelivery of DNA and doxorubicin. International Journal of Nanomedicine, 9, 4107-4116.
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4

Lipid-based Nanoparticle Formulation

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Calycoin, soybean phosphatidylcholine (SPC), cholesterol, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (DSPE-mPEG2000), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), and fetal bovine serum (FBS) were purchased from Sigma Co., Ltd. (Miami, USA). All other materials were of analytical grade.
Huang C., Xue L.F., Hu B., Liu H.H., Huang S.B., Khan S, & Meng Y. (2021). Calycosin-loaded nanoliposomes as potential nanoplatforms for treatment of diabetic nephropathy through regulation of mitochondrial respiratory function. Journal of Nanobiotechnology, 19, 178.
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5

Simvastatin Lipid Nanoformulation Development

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Simvastatin (SMV) was kindly obtained from Hikma Pharma (Cairo, Egypt). Soybean phosphatidylcholine (SPC), sodium deoxycholate (SDC), cholesterol, Span60, hydroxypropyl methyl cellulose and dialysis bags (molecular weight cut-off of 12–14 KDa) were purchased from Sigma-Aldrich (St. Louis, MO, USA).
Khafagy E.S., Almutairy B.K, & Abu Lila A.S. (2023). Tailoring of Novel Bile Salt Stabilized Vesicles for Enhanced Transdermal Delivery of Simvastatin: A New Therapeutic Approach against Inflammation. Polymers, 15(3), 677.
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6

Vardenafil Lipid Nanoparticle Formulation

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Vardenafil (VDF) was provided by G.N.P. Co. (6th of October City, Giza, Egypt). Cholesterol, hydroxypropyl cellulose (100,000 cps), sodium deoxycholate (SDC), and soybean phosphatidylcholine (SPC) were purchased from Sigma Aldrich (St. Louis, MO, USA). All other chemicals and reagents used were of analytical grade.
Aldawsari M.F., Khafagy E.S., Alotaibi H.F, & Abu Lila A.S. (2022). Vardenafil-Loaded Bilosomal Mucoadhesive Sponge for Buccal Delivery: Optimization, Characterization, and In Vivo Evaluation. Polymers, 14(19), 4184.
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7

Evaluation of Soybean Phospholipid Formulations

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SM (purity >80%) was purchased from Dalian Meilun Biotech Co, Ltd (Dalian, People’s Republic of China). Soybean phosphatidylcholine (purity >90%) and hydrogenated Soybean phosphatidylcholine (purity >95%) were obtained from Sigma-Aldrich (St Louis, MO, USA). SGC was supplied by Sinopharm Chemical Reagent Co Ltd (Shanghai, People’s Republic of China). Yiganling tablets were provided by Zhaohui Pharmaceutical Company (Shanghai, People’s Republic of China). CO2 with a purity of 99.99% was obtained from Shanghai Jiao Tong University (Shanghai, People’s Republic of China). All other chemicals were reagent grade and used as received.
Yang G., Zhao Y., Zhang Y., Dang B., Liu Y, & Feng N. (2015). Enhanced oral bioavailability of silymarin using liposomes containing a bile salt: preparation by supercritical fluid technology and evaluation in vitro and in vivo. International Journal of Nanomedicine, 10, 6633-6644.
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8

Sildenafil Citrate Liposomal Formulation

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Sildenafil citrate (SDF)
was supplied from Mash Premiere for the pharmaceutical industry (Cairo,
Egypt). Cholesterol, sodium deoxycholate (SDC), Span 60, soybean phosphatidylcholine
(SPC), and cellulose membrane (12,000–14,000 Da MWCO) were
procured from Sigma-Aldrich (St. Louis, MO, USA).
Almutairy B.K., Khafagy E.S., Aldawsari M.F., Alshetaili A., Alotaibi H.F, & Abu Lila A.S. (2024). Tailoring of Bilosomal Nanogel for Augmenting the Off-Label Use of Sildenafil Citrate in Pediatric Pulmonary Hypertension. ACS Omega, 9(17), 19536-19547.
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