Biograph 40 truepoint pet ct camera

¹⁸F-FP-CIT PET was performed using a Biograph 40 TruePoint PET/CT camera (Siemens Medical Systems, USA), which provides an in-plane spatial resolution of 2.0 mm full width at half maximum at the center of the field of view. Images were acquired from 0 to 10 min for early phase and 180–190 min for delayed phase after intravenous injection of ¹⁸F-FP-CIT (185 MBq). Emission PET data were acquired in the 3-dimensional mode after brain CT, which was performed in the spiral mode at 120 kVp and 380 mA (reference standard) using the CARE Dose 4D program. ¹⁸F-FP-CIT PET images were reconstructed from CT data for attenuation correction using the TrueX algorithm and an all-pass filter with a 336 × 336 matrix.

All scans were acquired during the diagnostic work-up of patients. All subjects fasted at least 6 h before [¹⁸F] FDG injection. FDG PET scans were acquired using an ECAT HR+ camera (Siemens), a Biograph 16 HiRez PET/CT camera (Siemens), or a Biograph 40 Truepoint PET/CT camera (Siemens). In all cases, a bolus of [¹⁸F] FDG was injected intravenously under standard conditions: lying in a dimly lit, quiet room with eyes and ears open.
PET acquisitions were performed in list mode thirty minutes after injection. Images were acquired dynamically for 30 min on the ECAT HR+ (3D mode) and for 15–20 min on the HiRez and Truepoint (3D and listmode). During the acquisition, the patient’s head was immobilized with a vacuum pillow or headholder. All images were corrected for attenuation, scatter, and decay.
On the ECAT HR+, images were corrected for attenuation with the attenuation map, acquired with a transmission scan using ⁶⁸Ge/⁶⁸Ga rod sources, and projection data were reconstructed using 3-dimensional filtered back projection with a Hanning post-filter. On the HiRez and Truepoint, images were reconstructed using ordered-subset expectation maximization (OSEM) with 5 iterations over 8 subsets and 3 iterations over 21 subsets, respectively, with an 8 mm Gaussian kernel.