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Silencer select validated small interfering rna

Manufactured by Thermo Fisher Scientific
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Silencer Select Validated Small Interfering RNA is a laboratory product designed for gene silencing experiments. It functions by introducing small, double-stranded RNA molecules into cells, which can temporarily suppress the expression of specific target genes.

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Lab products found in correlation

Mef2c, by Thermo Fisher Scientific (1 mentions) Lipofectamine rnaimax, by Thermo Fisher Scientific (1 mentions) Lipofectamine rnaimax reagent, by Thermo Fisher Scientific (1 mentions)

2 protocols using silencer select validated small interfering rna

1

Silencing HuR and MEF2C in RL14 Cells

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Silencer select validated small interfering RNA (siRNA) for HuR (catalog no. s4608) and for MEF2C (catalog no. s8653) and negative control siRNA (catalog no. 4390843) were purchased from Thermo Fisher Scientific (Waltham, MA). To inhibit HuR or MEF2C, siRNA was transfected into RL14 cells using Lipofectamine RNAiMAX (Life Technologies, Carlsbad, CA), following the manufacturer's protocol.
Zhou A., Shi G., Kang G., Xie A., Liu H., Jiang N., Liu M., Jeong E, & Dudley SC J.r. (2018). RNA Binding Protein, HuR, Regulates SCN5A Expression Through Stabilizing MEF2C transcription factor mRNA. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 7(9), e007802.
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2

Silencing HIF-1α in Cell Cultures

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HIF-1α silencing (si-HIF-1α) was performed by Silencer® Select & Validated small interfering RNA (Thermo Fisher Scientific) using the assay ID s6539 and a non-targeting negative control siRNA. Cells were transfected with Lipofectamine RNAiMAX Reagent (Invitrogen, Carlsbad, CA, USA).
Iacobini C., Vitale M., Pugliese G, & Menini S. (2021). Normalizing HIF-1α Signaling Improves Cellular Glucose Metabolism and Blocks the Pathological Pathways of Hyperglycemic Damage. Biomedicines, 9(9), 1139.
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