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Chlorzoxazone

Manufactured by Cayman Chemical
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Sourced in United States

Chlorzoxazone is a laboratory chemical supplied by Cayman Chemical. It is a crystalline solid with the molecular formula C₇H₅ClNO. This product is intended for research use only and its core function is as a chemical intermediate.

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Lab products found in correlation

Phenacetin, by Merck Group (3 mentions) Testosterone, by Cayman Chemical (3 mentions) P nitrophenol, by Merck Group (2 mentions) 6 hydroxychlorzoxazone, by Cayman Chemical (2 mentions) Rat tail collagen 1, by Enzo Life Sciences (2 mentions) Dimethyl sulfoxide (dmso), by Thermo Fisher Scientific (2 mentions) Sodium hydroxide (naoh), by Merck Group (2 mentions) Dextrorphan d3, by Merck Group (2 mentions) Bupropion hydrochloride, by Merck Group (2 mentions) 7 hydroxycoumarin, by Thermo Fisher Scientific (2 mentions) Midazolam, by Cayman Chemical (2 mentions) Acetaminophen d4, by Cayman Chemical (2 mentions) Hydroxybupropion d6, by Cambridge Isotopes (2 mentions) 7 hydroxycoumarin d5 sulfate, by LGC (2 mentions) 7 hydroxycoumarin 13c6 glucuronide, by LGC (2 mentions) Hydroxymidazolam 13c3, by Corning (2 mentions) Hydroxytestosterone d7, by Corning (2 mentions) Nadph tetrasodium salt, by Merck Group (1 mentions) L α phosphatidylcholine pc, by Merck Group (1 mentions) Dl dithiothreitol, by Merck Group (1 mentions)

4 protocols using chlorzoxazone

1

Detailed Analytical Protocol Reagents

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DL-dithiothreitol (DTT), p-Nitrophenol (pNP),
p-Nitroanizol and L-α- phosphatidylcholine (PC) from
egg yolk were the products of Sigma-Aldrich (St. Louis, MO). NADPH tetrasodium
salt was from EMD Millipore (Billerica, MA). 7-ethoxyresorufm was from AnaSpec
(San Jose, CA, USA). 7-ethoxy-4-cyanocoumarin (CEC), 7-hydroxy-4-cyanocoumarin
(CHC) and BODIPY 577/618 maleimide were from Invitrogen/Molecular Probes Inc.
(Eugene, CA).. Chlorzoxazone, 6-hydroxy Chlorzoxazone and resorufin were the
products of Cayman Chemical (Ann Arbor, MI). L-α-phosphatidylethanolamine
(PE) from bovine liver and
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate (phosphatidic acid,
PA) were obtained from Avanti Polar Lipids, Inc. (Alabaster, AL).
Octyl-β-D-glucopyranoside (octylglucoside) was the product of Fluka
Honeywell Specialty Chemicals (Seelze, Germany). All other reagents were of ACS
grade and used without additional purification.
Davydova N.Y., Dangi B., Maldonado M.A., Vavilov N.E., Zgoda V.G, & Davydov D.R. (2019). Toward a systems approach to cytochrome P450 ensemble: interactions of CYP2E1 with other P450 species and their impact on CYP1A2. The Biochemical journal, 476(23), 3661-3685.
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2

Analytical Reagents for Drug Metabolism

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All chemicals and reagents were used as received unless otherwise specified. Chlorzoxazone, dextromethorphan (hydrobromide hydrate), (S)-mephenytoin, midazolam, testosterone, and acetaminophen-d4 were purchased from Cayman Chemical Company. Collagen I (rat tail) was purchased from Enzo Life Sciences. Phenacetin, dextrorphan-d3, bupropion hydrochloride, and sodium hydroxide (NaOH) were purchased from Millipore Sigma. Dimethyl sulfoxide (DMSO) and 7-hydroxycoumarin were purchased from Fisher Scientific. Hydroxybupropion-d6 was purchased from Cambridge Isotope Laboratories. 6-hydroxyChlorzoxazone-d2 was purchased from Clearsynth. 7-hydroxycoumarin-d5-sulfate and 7-hydroxycoumarin-13C6-glucuronide were purchased from Toronto Research Chemicals. 4-hydroxymephenytoin-d3 was purchased from MuseChem. Hydroxymidazolam-13C3 and hydroxytestosterone-d7 were purchased from Corning.
Diprospero T.J., Brown L.G., Fachko T.D, & Lockett M.R. (2023). HepaRG cells undergo increased levels of post-differentiation patterning in physiologic conditions when maintained as 3D cultures in paper-based scaffolds. bioRxiv.
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3

Comprehensive Enzymatic Assay Protocol

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Acetaminophen, bufurolol, 1’-hydroxybufurolol, caffeine, dexamethasone, ethoxyresorufin, glutathione (reduced), mephenytoin, 4-hydroxymephenytoin, pentoxyresorufin, resorufin, phenacetin, warfarin, 7-hydroxywarfarin, phenylmethanesulfonyl fluoride, p-nitrophenol (PNP), UDP-glucuronic acid (ammonium salt) (UDPGA), 1-chloro-2, 4-dinitrobenzene (CDNB), 2-mercaptoethanol, 3’-Phosphoadenosine-5’-phosphosulfate (PAPS), flavin adenine dinucleotide, dicoumarol, 2,6 dichlorophenolindophenol, 2-naphthylsulfate, high performance liquid chromatography (HPLC) grade acetonitrile, and methanol were purchased from Sigma–Aldrich (St. Louis, MI, USA). Nicotinamide adenine dinucleotide phosphate (NADPH) and dimethyl sulfoxide were purchased from SRL Pvt. Ltd (Mumbai, Maharashtra, India). Testosterone, 6b-hydroxyTestosterone, chlorzoxazone, and 6-hydroxychlorzoxazone were purchased from Cayman chemical company (USA). Ultrapure water (18.2 M/Ω cm) was obtained from Milli-Q PLUS PF water. All other chemicals were commercially available or HPLC grade.
Kumar D., Trivedi N, & Dixit R.K. (2016). Evaluation of the synergistic effect of Allium sativum, Eugenia jambolana, Momordica charantia, Ocimum sanctum, and Psidium guajava on hepatic and intestinal drug metabolizing enzymes in rats. Journal of Intercultural Ethnopharmacology, 5(4), 372-382.
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4

Analytical Reagents for Drug Metabolism

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All chemicals and reagents were used as received unless otherwise specified. Chlorzoxazone, dextromethorphan (hydrobromide hydrate), (S)-mephenytoin, midazolam, testosterone, and acetaminophen-d4 were purchased from Cayman Chemical Company. Collagen I (rat tail) was purchased from Enzo Life Sciences. Phenacetin, dextrorphan-d3, bupropion hydrochloride, and sodium hydroxide (NaOH) were purchased from Millipore Sigma. Dimethyl sulfoxide (DMSO) and 7-hydroxycoumarin were purchased from Fisher Scientific. Hydroxybupropion-d6 was purchased from Cambridge Isotope Laboratories. 6-hydroxyChlorzoxazone-d2 was purchased from Clearsynth. 7-hydroxycoumarin-d5-sulfate and 7-hydroxycoumarin-13C6-glucuronide were purchased from Toronto Research Chemicals. 4-hydroxymephenytoin-d3 was purchased from MuseChem. Hydroxymidazolam-13C3 and hydroxytestosterone-d7 were purchased from Corning.
Diprospero T.J., Brown L.G., Fachko T.D, & Lockett M.R. (2023). HepaRG cells undergo increased levels of post-differentiation patterning in physiologic conditions when maintained as 3D cultures in paper-based scaffolds. Research Square.
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