Participants were prospectively recruited from childhood and young adulthood (6–25 years of age) with the use of flyers/advertisement posted in clinics, on social media, and through the University of Pittsburgh Clinical Translational Research Registry. Exclusion criteria included (a) severe intellectual disability, (b) clinically diagnosed genetic syndrome associated with neurocognitive impairment as identified from the medical record, and (c) standard MRI exclusion criteria such as metallic implants. Informed consent was obtained according to the standard procedures in use at the University of Pittsburgh from all participants aged 18 and over. Consent from one parent and assent was obtained for all participants under the age of 18. All participants were scanned using a 3 Tesla Siemens Skyra system (Munich, Germany) at UPMC Children’s Hospital of Pittsburgh using a 32-channel head coil.
Skyra system
Manufactured by Siemens
Sourced in Germany
The Skyra system is a magnetic resonance imaging (MRI) scanner developed by Siemens. It is designed to acquire high-quality images of the human body. The Skyra system utilizes a powerful superconducting magnet and advanced imaging technologies to capture detailed anatomical information.
Automatically generated - may contain errors
Lab products found in correlation
20 channel head neck coil, by Siemens (3 mentions)
32 channel head coil, by Siemens (3 mentions)
16 channel spine array coil, by Siemens (2 mentions)
Signa system, by GE Healthcare (2 mentions)
Dotarem, by Guerbet (2 mentions)
Somatom sensation 64 row scanner, by Siemens (1 mentions)
64ch head coil, by Siemens (1 mentions)
Prisma, by Siemens (1 mentions)
Achieva system, by Siemens (1 mentions)
18 channel body coil, by Siemens (1 mentions)
30 protocols using skyra system
1
Age-Dependent Neurodevelopmental Evaluation
2
3T fMRI Acquisition Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Blood oxygen level-dependent T2*-weighted functional images were acquired on a 3T Skyra system (Siemens, Germany) using echo-planar imaging (EPI) with a 32-channel head coil. Images were acquired with a 45° oblique angle with the following parameters: 3300 ms TR; 30 ms TE; 1 mm inter-slice gap, 192 mm field of view, and 48 axial slices with 2 mm slice thickness resulting in 3 mm isotropic voxels. A single echo field map was recorded for distortion correction of the acquired EPI. After the functional scans, a T1-weighted 3-D structural image (1 mm3) was acquired to coregister and display the functional data.
3
Multimodal Brain Imaging Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Magnetic resonance imaging data were collected using a 3T Siemens Skyra system (Erlangen, Germany) and a 20-channel head-neck coil at Keelung Chang Gung Memorial Hospital. High-resolution T1-weighted anatomical images (3D-MPRAGE with 256 × 256 × 256 matrix size, 1 mm3 isotropic cube, flip angle (FA) = 8, repeat time (TR) = 2200 ms, echo time (TE) = 2.45 ms, and inverse time = 900 ms) were acquired before the functional scans for localization reference. Customized cushions were used to minimize head motion during each scan. rs-fMRI scans were subsequently acquired using a single-shot, gradient-recalled echo-planar imaging sequence (TR/TE/FA = 2,500 ms/27 ms/90, field of view = 220 mm, matrix size = 64 × 64, 35 slices with 3 mm thickness, 200 measurements) aligned along the anterior commissure-posterior commissure line, thus allowing whole-brain coverage.
4
HCP Minimal Preprocessing Pipeline for fMRI
5
Multimodal MRI Acquisition for Neuroimaging
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
During data acquisition, participants were in constant contact with research personnel through real-time audiovisual monitoring. Structural MRI data were collected on a 3T Siemens Skyra System with a 32-channel head coil, and consisted of one T1-weighted three-dimensional 1 mm isotropic T1 (TR = 2.4s, TE = 1.94 ms, flip angle = 8°, FOV = 256 mm, slices = 192), and one T2-weighted turbo spin echo (TSE) scan (TR = 7.79s, TE = 66 ms, flip angle = 145°, FOV = 170 mm, in plane resolution = 0.4 × 0.4 mm, slice thickness = 2 mm, slices = 32) per current best practices (Mueller et al., 2018 (link); Olsen et al., 2019 (link); Wisse et al., 2021 (link); Yushkevich et al., 2015 (link)).
6
In Vivo 1H MRS of Femoral Bone Marrow
7
3T MRI Acquisition of Cervical and Thoracic Spine
8
Multimodal Neuroimaging for Mild Traumatic Brain Injury
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Non-contrast head CT was performed on a Siemens Somatom Sensation 64-row scanner (Siemens Healthineers, Erlangen, Germany) in 299 of the patients as a part of routine clinical assessment. In addition, brain MRI scans were acquired on a 3 Tesla Siemens Skyra System (32-channel head coil; Siemens Healthineers) within 72 h of injury for 198 patients with mTBI. The following sequences were included: three-dimensional T1, T2, susceptibility-weighted imaging, diffusion-weighted imaging (DWI), and fluid-attenuated inversion recovery. All CT and MRI scans were read by experienced radiologists,34 (link) and patients with mTBI and intracranial traumatic findings on CT and/or MRI were considered to have complicated mTBI.
9
Resting-state fMRI of Healthy Young Adults
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
The dataset was acquired from the S1200 Release of the WU-Minn Human Connectome Project (HCP) database that has been fully described elsewhere61 (link). Participants were healthy young adults from 22 to 37 years old. Participants who completed two sessions of resting-state fMRI scans (Rest1 and Rest2) were selected (n = 1009). Data collection utilized multiband EPI via a customized Siemens 3T MR scanner (Skyra system). Each scanning session included two sequences, each with different phase encoding directions (left-to-right and right-to-left), lasting 14 minutes and 33 seconds, with a TR of 720 ms, a TE of 33.1 ms, and a voxel size of 2-mm isotropic. The sequences from each session were merged, totaling 29 minutes and 6 seconds of data per session. This approach of merging data from opposite phase encodings aimed to neutralize any biases introduced by the direction of phase encoding. The denoised volumetric data, processed through ICA-FIX, were obtained from the online HCP database. Further details on the resting-state fMRI data collection and preprocessing steps are documented in other publications62 (link),63 (link). Static functional connectivity (FC) matrices of the Rest1 period produced by Pearson correlation were used for the analysis.
10
Lumbar MRI Evaluation of Nerve Impingement
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
The third phase of the study included MRI imaging of the lumbar spine; a commonly used reference standard for the diagnosis of suspected lumbar pain with/without sciatica. A 3T Siemens SKYRA system (Siemens Medical Solutions, Erlangen, Germany) was used to collect T2 weighted axial and sagittal images to determine presence/absence of nerve impingement for all subjects. MRI images were reviewed by an American Board of Radiology certified neuroradiologist with 9 years of experience (EP) who was blinded to all subject’s demographics and characteristics. Nerve impingement grouping (impingement” or “no impingement”) was determined by the neuroradiologist based on a combination of the integrity of the lumbar anatomical regions, nerve root appearance, and conus level. Lumbar anatomical regions (annular fissure, disc desiccation, shortened pedicles, disc osteophyte, facet joint compression, and thecal sac diameter) were graded as normal, mild (nerve root is contacted on one side or surrounding fat effaced less than 90 degrees), moderate (nerve root contacted on two sides or fat effaced 90+ degrees), or severe (nerve root contacted on two sides, fat effaced 90+degrees, and nerve root visibly compressed). The clinician performing sensory and LE measurements was also blinded to MRI image results during phase 2 of testing.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!