Ticarcillin disodium

Implantations of intravenous catheters with back mounts were performed under anesthesia with a cocktail containing 8.6 mg/kg of xylazine, 1.5 mg/kg of acepromazine, and 43 mg/kg of ketamine in bacteriostatic saline and allowed to recover for 5–7 days.^{24 (link),28 (link),41 (link),66 (link)} Catheter patency was maintained by daily flushes with a solution of 0.1 mL bacteriostatic saline containing heparin sodium (10 U/mL; American Pharmaceutical Partners, East Schaumburg, IL), streptokinase (0.67 mg/mL; Sigma Chemical), and ticarcillin disodium (66.67 mg/mL; Research Products International, Mt. Prospect, IL) immediately following daily oxycodone self-administration sessions. Proper catheter function was verified periodically throughout experiments by intravenous administration of 10 mg/kg of methohexital sodium (Monarch Pharmaceuticals Inc., Bristol, TN), a dose sufficient to briefly anesthetize the animal only when administered intravenously. All rats were allowed 5–7 days of recovery after surgery before initiation of self-administration training.

Rats (n = 156) were implanted with intravenous catheters with back mounts under anesthesia with a cocktail containing 8.6 mg/kg of xylazine, 1.5 mg/kg of acepromazine, and 43 mg/kg of ketamine in bacteriostatic saline and allowed to recover for 5–7 days before initiation of self-administration training (Anastasio et al., 2014a (link), 2014b (link), 2013; Neelakantan et al., 2017 (link); Sholler et al., 2019 ). Catheter patency was maintained by daily flushes with a solution of 0.1 ml bacteriostatic saline containing heparin sodium (10 U/ml; American Pharmaceutical Partners, East Schaumburg, IL), streptokinase (0.67 mg/ml; Sigma Chemical), and ticarcillin disodium (66.67 mg/ml; Research Products International, Mt. Prospect, IL) immediately following daily cocaine self-administration sessions.