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Mephedrone hydrochloride

Manufactured by Merck Group
Sourced in United States

Mephedrone hydrochloride is a chemical compound used in laboratory settings. It is a crystalline solid that is soluble in water. The primary function of this product is for use in scientific research and analysis, as it can be used as a reagent or intermediate in various chemical processes. No further details on intended use can be provided.

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2 protocols using mephedrone hydrochloride

1

Psychostimulant and Opioid Administration in Rodents

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Methamphetamine hydrochloride (METH, 2.0 mg/kg, i.p., Sigma-Aldrich), mephedrone hydrochloride (racemic mixture; MEPH, 2.0 and 2.5 mg/kg, i.p., Sigma-Aldrich), Nicotine Bitartrate Dihydrate (NIC, 0.5 and 1.0 mg/kg, s.c, Sigma-Aldrich), and Morphine hydrochloride (MOR, 10 mg/kg, i.p., Sigma-Aldrich) were dissolved in sterile 0.9% and administered at the denoted doses. Racemic (+/−) Blebb (Tocris) was diluted to 1 mg/mL in a vehicle of 0.9% SAL and 6.7% DMSO/25% Hydroxypropyl β-Cyclodextrin (HPβCD) and administered at a dose of 10 mg/kg (i.p.) (Young et al. 2016 (link); Briggs et al. 2017 (link); Young et al. 2017 (link)).
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2

Quantifying Neurochemical Biomarkers

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Methylone hydrochloride, MDPV hydrochloride, (±) mephedrone hydrochloride, and (±) MDMA hydrochloride were obtained from the NIDA Research Resources Drug Supply Program. (+) methamphetamine hydrochloride, D-amphetamine sulfate, MPTP hydrochloride, DA, polyclonal antibodies against glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and all buffers and HPLC reagents were purchased from Sigma-Aldrich (St. Louis, MO, USA). Bicinchoninic acid protein assay kits were obtained from Pierce (Rockford, IL, USA). Polyclonal antibodies against rat tyrosine hydroxylase (TH) were produced as described previously (Kuhn and Billingsley 1987 (link)). Monoclonal antibodies against rat DAT were generously provided by Dr Roxanne A. Vaughan (University of North Dakota, Grand Forks, ND, USA). Polyclonal antibodies against glial fibrillary acidic protein (GFAP) were obtained from Thermo Scientific (Rockford, IL, USA). IRDye secondary antibodies for Odyssey Imaging Systems were purchased from LiCor Biosciences (Lincoln, NE, USA).
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