Male C57BL/6J mice (8 to 10 week-old) and male Wistar rats (250–300 g) were purchased from Janvier (Le Genest-St-Isle, France). CypD knock-out mice (Ppif−/− mice) were obtained from Jackson Laboratories (Bar Harbor, Maine, USA). Animals were housed in an air-conditioned room with a 12 h light–dark cycle and received standard rodent chow and drinking water ad libitum. All animal procedures used in this study were in accordance with the Directives of the European Parliament (2010/63/EU-848 EEC) and were approved by the Animal Ethics Committee Afssa/ENVA/Universite Paris Est Creteil (approval number 09/12/14-02).
Cypd knock out mice ppif mice
Manufactured by Jackson ImmunoResearch
Sourced in United States
CypD knock-out mice (Ppif−/− mice) are laboratory animals with a genetic modification that results in the inactivation of the Ppif gene, which encodes the cyclophilin D (CypD) protein. CypD is a key component of the mitochondrial permeability transition pore, and its absence in these mice can affect various cellular processes related to mitochondrial function.
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2 protocols using cypd knock out mice ppif mice
1
Animal Models for Mitochondrial Studies
2
Murine Model of Mitochondrial Regulation
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All animal procedures used in this study were in accordance with the Directives of the European Parliament (2010/63/EU-848 EEC) and the recommandations of the French Ministère de l'Agriculture. Male C57BL/6J mice (8 to 10 week-old) were purchased from Janvier (Le Genest-St-Isle, France). CypD knock-out mice (Ppif -/-mice) were obtained from Jackson Laboratories (Bar Harbor, Maine, USA). Mice were housed in an air-conditioned room with a 12 h light-dark cycle and received standard rodent chow and drinking water ad libitum.
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