Acetonitrile ch3cn

Manufactured by Thermo Fisher Scientific

Sourced in United States, India

Acetonitrile (CH3CN) is a colorless, volatile organic liquid commonly used as a solvent in various laboratory applications. Its primary function is to serve as a polar aprotic solvent for a wide range of chemical reactions and analytical techniques. Acetonitrile exhibits a low viscosity and a high dielectric constant, making it a suitable solvent for both polar and non-polar compounds.

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Lab products found in correlation

5 protocols using acetonitrile ch3cn

Bergamottin Inhibition of Midazolam Metabolism

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Bergamottin was purchased from ChromaDex (Irvine, CA; purity ≥ 96.9%) and Sigma-Aldrich (St. Louis, MO; purity ≥ 98.0); DHB was purchased from Cayman Chemical (Ann Arbor, MI; purity ≥ 98.0%) and Sigma-Aldrich (purity ≥ 97.2%). Midazolam (purity ≥ 99.9%), 1′-hydroxyMidazolam (purity ≥ 98.0%), ketoconazole (purity ≥ 98.0%), alprazolam (purity ≥ 99.0%), and NADPH were purchased from Sigma-Aldrich. Purity of standards is reported as determined by HPLC (TLC in the case of alprazolam) by the manufacturers. A not-from-concentrate grapefruit juice (Simply Grapefruit, Simply Orange Juice Co., Apopka FL; lot AMC3 E 01:13) was purchased from a local grocery store. Methanol (MeOH) was purchased from Pharmco-Aaper (Shelbyville, KY) and Fischer Scientific (Waltham, MA). UPLC-grade water (H₂O) and acetonitrile (CH₃CN) were purchased from Fisher Scientific. Pooled human intestinal microsomes (HIM) (n = 18 donors) were purchased from Xenotech (Lenexa, KS).

VanderMolen K.M., Ainslie G.R., Paine M.F, & Oberlies N.H. (2014). Labeled Content of Two Furanocoumarins in Dietary Supplements Correlates with neither Actual Content nor CYP3A Inhibitory Activity. Journal of pharmaceutical and biomedical analysis, 98, 260-265.

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Comprehensive Microcystin Analytical Protocol

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MC-LR, MC-RR, and MC-LA were purchased from Cayman Chemical (Ann Arbor, MI, USA). MC-YR, MC-LF, and MC-LW were purchased from Enzo Life Sciences (Farmingdale, NY, USA). C₂D₅ MC-LR was purchased from Cambridge Isotope Laboratories (Tewksbury, MA, USA). MC-LR-Cys was synthesized by the Westrick group (Wayne State University, Detroit, MI, USA) [46 (link)]. ACS-grade zinc sulfate (ZnSO₄) and HPLC-grade water, methanol (CH₃OH), and acetonitrile (CH₃CN) were purchased from Fisher Scientific (Pittsburgh, PA, USA). Reagent-grade formic acid (FA) was purchased from Sigma (St. Louis, MO, USA).

Baliu-Rodriguez D., Kucheriavaia D., Palagama D.S., Lad A., O’Neill G.M., Birbeck J.A., Kennedy D.J., Haller S.T., Westrick J.A, & Isailovic D. (2020). Development and Application of Extraction Methods for LC-MS Quantification of Microcystins in Liver Tissue. Toxins, 12(4), 263.

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Transition Metal Electrochemistry Reagents

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Materials. All solvents and reagents were laboratory reagent grade or better and used as received. Potassium hydroxide (KOH, Sigma-Aldrich, ≥ 85%), tetra-n-butylammonium hydroxide [Bu 4 N]OH (1.0 M in methanol, Alfa Aesar), manganese(II) acetate tetrahydrate (Mn(O 2 CCH 3 ) 2 •4H 2 O, Merck), lithium perchlorate anhydrous (LiClO 4 , ≥ 98%, Sigma-Aldrich), calcium trifluoromethanesulfonate anhydrous (Ca(CF 3 SO 3 ) 2 , Aldrich, 99.9%), strontium nitrate anhydrous (Sr(NO 3 ) 2 , 99+%, Strem) were used as received. Acetonitrile (CH 3 CN, Fisher, HPLC grade), and tetra-n-butyl-ammonium perchlorate ([Bu 4 N]ClO 4 , Fluka) for electrochemical measurements were stored under an argon atmosphere in a dry-glove box.

Gouré E., Gerey B., Astudillo C.N., Pécaut J., Sirach S., Molton F., Fortage J, & Collomb M.N. (2021). Self-Assembled Heterometallic Complexes by Incorporation of Calcium or Strontium Ion into a Manganese(II) 12-Metallacrown-3 Framework Supported by a Tripodal Ligand with Pyridine-Carboxylate Motifs: Stability in Their Manganese(III) Oxidized Form. Inorganic chemistry, 60(11).

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Simultaneous HPLC Analysis of Quercetin and Hydrochlorothiazide

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Quercetin
(QT) and methanol (HPLC grade) were purchased from Sigma-Aldrich Chemicals,
USA. Hydrochlorothiazide (HCZ) was procured from Clarsynth Labs, Mumbai,
India. Capmul MCM NF (CAP MCM NF) and Cremophor RH40 (CR RH40) were
obtained from Gattefosse (Saint-Priest, Cedex, France) and BASF (Ludwigshafen,
Germany), respectively. Acetonitrile (CH₃CN) and ammonium
formate (NH₄HCO₂) were procured from Thermo
Fisher Scientific, India. HPLC grade water was obtained from Rankem,
India. All other chemicals and reagents were of analytical grade.

Das S.S., Verma P.R., Sekarbabu V., Mohanty S., Pattnaik A.K., Ruokolainen J., Kesari K.K, & Singh S.K. (2023). Liquid Chromatography–Electrospray Ionization Tandem Mass Spectrometry Estimation of Quercetin-Loaded Nanoemulsion in Rabbit Plasma: In Vivo–In Silico Pharmacokinetic Analysis Using GastroPlus. ACS Omega, 8(13), 12456-12466.

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Characterization of Chemical Standards

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Formic acid (HCOOH), methanol (CH 3 OH) and acetonitrile (CH 3 CN) were purchased from Thermo Fisher Scientific. Water was obtained using an 18 Ωm Milli-Q system (EMD Millipore Corporation). All chemicals and solvents were of Optima LCMS grade. The following standards were obtained from Sigma-Aldrich: doxycycline, tetracycline, roxithromycin, erythromycin, puromycin, novobiocin, amphotericin B, cycloheximide, mitomycin C, vancomycin, ursolic acid, betulinic acid, and oleanolic acid. Chloramphenicol and nystatin were acquired from Calbiochem. Florfenicol and cyclosporin A were purchased from Santa Cruz Biotechnology. Azithromycin was purchased from TCI. Thiamphenicol was acquired from Spectrum Chemicals. Actinomycin D was purchased from RPI. All standards were assessed by NMR (Supporting Information Figures S2-S21) and, where required, purified by HPLC (Agilent 1200, Phenomenex Synergi C18 4.6 x 250 mm, 2 mL/min, H 2 O + 0.02% HCOOH and CH 3 CN).

Carnevale Neto F., Clark T.N., Lopes N.P, & Linington R.G. (2022). Evaluation of Ion Mobility Spectrometry for Improving Constitutional Assignment in Natural Product Mixtures. Journal of natural products, 85(3).

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