Finepointe software

Manufactured by Data Sciences International

Sourced in Sao Tome and Principe

FinePointe software is a data acquisition and analysis solution designed for use with laboratory research equipment. It provides tools for collecting, organizing, and analyzing data generated from experiments. The software's core function is to facilitate the capture, management, and interpretation of experimental data.

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Lab products found in correlation

Buxco small animal whole body plethysmography, by Data Sciences International (1 mentions) Whole body plethysmography system, by Data Sciences International (1 mentions)

8 protocols using finepointe software

Unrestrained Mouse Respiratory Monitoring

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Respiratory function was monitored in unrestrained mice using Buxco small animal whole-body plethysmography (Data Sciences International, New Brighton, MN) and FinePointe software (Data Sciences International, New Brighton, MN). The system was calibrated each day prior to data collection. On the day of data collection, animals were placed in individual chambers and given 30 min to acclimate; followed by 60 min of data collection. The software averaged the data over each minute and recorded a value every minute for 60 min. To ensure data was representative, breath frequency was used to ensure the mouse had not held its breath, buried its head under its body or was breathing too rapidly. Mean breath frequency was calculated and data which fell outside 1SD of the mean was excluded from the data analysis (Roberts et al., 2015 (link)).

Loehr J.A., Wang S., Cully T.R., Pal R., Larina I.V., Larin K.V, & Rodney G.G. (2018). NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice. eLife, 7, e31732.

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Measuring Airway Resistance and Tidal Volume

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Airway resistance is the resistance of the respiratory tract to airflow during inhalation and exhalation. Tidal volume is the lung volume representing the normal volume of air displaced between normal inhalation and exhalation when extra effort is not applied. Airway resistance and tidal volume can be measured by plethysmography. We also confirmed that the methacholine test did not affect the inflammatory parameter in this study. One day after the final exposure to OVA, mice in the OVA, OVA + IBMX, OVA + Vinp, and OVA + Dex groups were exposed to methacholine (4, 8, and 16 mg/ml) for 1 min. After methacholine exposure, the airway resistance of the lungs was measured for 3 min using a Buxco® non-invasive double-chamber plethysmograph (Data Sciences International, St. Paul, MN, USA). Measured airway resistance and tidal volume were automatically calculated by FinePointe software (Data Sciences International) and expressed as a ratio from the value at 0 mg/ml (n = 9).

Choi W.S., Kang H.S., Kim H.J., Lee W.T., Sohn U.D, & Lee J.Y. (2021). Vinpocetine alleviates lung inflammation via macrophage inflammatory protein-1β inhibition in an ovalbumin-induced allergic asthma model. PLoS ONE, 16(4), e0251012.

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Measuring Diffusing Capacity in Mice

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Mice were anesthetized with ketamine-xylazine, tracheostomized and the diffusing capacity for carbon monoxide (DFCO) was calculated^{70 (link)}. In brief, 0.8 ml mixed gas (0.5% Ne, 21% O₂, 0.5% CO, and 78% N₂) was instilled into the mice lungs and withdrawn 2 s later for analysis on a 3000 Micro GC Gas Analyzer (Infinicon) running EZ IQ software v3.3.2 (Infinicon). DFCO was calculated as 1-(CO₁/CO₀)/(Ne₁/Ne₀) where 0 and 1 refer to the gas concentration before and after instillation respectively. Respiratory function was analyzed using a forced pulmonary maneuver system^{71 (link)} (Buxco Research Company, Data Sciences International) running FinePointe Software (version 6, Data Sciences International). At least three maneuvers were performed per mouse and the mean value was taken.

Günes Günsel G., Conlon T.M., Jeridi A., Kim R., Ertüz Z., Lang N.J., Ansari M., Novikova M., Jiang D., Strunz M., Gaianova M., Hollauer C., Gabriel C., Angelidis I., Doll S., Pestoni J.C., Edelmann S.L., Kohlhepp M.S., Guillot A., Bassler K., Van Eeckhoutte H.P., Kayalar Ö., Konyalilar N., Kanashova T., Rodius S., Ballester-López C., Genes Robles C.M., Smirnova N., Rehberg M., Agarwal C., Krikki I., Piavaux B., Verleden S.E., Vanaudenaerde B., Königshoff M., Dittmar G., Bracke K.R., Schultze J.L., Watz H., Eickelberg O., Stoeger T., Burgstaller G., Tacke F., Heissmeyer V., Rinkevich Y., Bayram H., Schiller H.B., Conrad M., Schneider R, & Yildirim A.Ö. (2022). The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD. Nature Communications, 13, 1303.

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Hamster Pulmonary Function Assessment

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Pulmonary function was assessed using a whole-body plethysmography system (Data Sciences International) as previously described.⁴¹ (link) In brief, hamsters were placed individually in unrestrained plethysmography chambers. After 30 s for acclimatisation, respiratory parameters were acquired over a 3-min period by using FinePointe software (Data Sciences International).

Sasaki M., Sugi T., Iida S., Hirata Y., Kusakabe S., Konishi K., Itakura Y., Tabata K., Kishimoto M., Kobayashi H., Ariizumi T., Intaruck K., Nobori H., Toba S., Sato A., Matsuno K., Yamagishi J., Suzuki T., Hall W.W., Orba Y, & Sawa H. (2023). Combination therapy with oral antiviral and anti-inflammatory drugs improves the efficacy of delayed treatment in a COVID-19 hamster model. eBioMedicine, 99, 104950.

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Respiratory Function in Infected Mice

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To examine the impact of infection, with or without prior vaccination, on the breathing and respiratory function of animals, we studied WT and β-ENaC transgenic mice in a Buxco Small Animal Whole Body Plethysmography (WBP) chamber (Data Sciences International). Animals were acclimated to the chamber during a 20-min session in the week prior to the recorded WBP sessions. A baseline measurement of breathing was recorded the day prior to infection, and then post-infection breathing was monitored immediately prior to euthanasia, 15 h post-infection. All WBP sessions included 5 min of acclimation, then data were recorded for 15 min. Data were compiled, analyzed using the FinePointe software (Data Sciences International), and then exported to GraphPad Prism (Version 7; GraphPad Software, Inc.) for statistical analysis. Collected data include breadths per minute, enhanced pause, pause, tidal midexpiratory flow (EF50), tidal volume of breadth (TVb), time of inspiration (Ti), and time of expiration (Te).

Blackwood C.B., Mateu-Borrás M., Sen-Kilic E., Pyles G.M., Miller S.J., Weaver K.L., Witt W.T., Huckaby A.B., Kang J., Chandler C.E., Ernst R.K., Heath Damron F, & Barbier M. (2022). Bordetella pertussis whole cell immunization protects against Pseudomonas aeruginosa infections. NPJ Vaccines, 7, 143.

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Respiratory Function in Mice

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Respiratory function was tested in unrestrained mice using a whole-body plethysmograph (Buxco Respiratory Products, Data Sciences International, St. Paul, MN). The mouse was weighed and placed into the chamber for 15 min to acclimate, and respiratory flow data were recorded for 5 min using FinePointe software (Data Sciences International, St. Paul, MN). The measurements were done for two consecutive days. For data analysis, average values for TV, MV, TV/BW, and MV/BW were used.

Yonekawa T., Rauckhorst A.J., El-Hattab S., Cuellar M.A., Venzke D., Anderson M.E., Okuma H., Pewa A.D., Taylor E.B, & Campbell K.P. (2022). Large1 gene transfer in older myd mice with severe muscular dystrophy restores muscle function and greatly improves survival. Science Advances, 8(21), eabn0379.

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Whole-Body Plethysmography in Mice

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Non-invasive whole-body plethysmography was performed using the Buxco equipment for small animals (Data Sciences international, Buxco Electronics, St. Paul, Minnesota, USA). Data was analyzed using the FinePointe software (Data Sciences International, St. Paul, Minnesota, USA). The mice were acclimatized for 10 minutes, followed by 5 minutes of exposure to room air, followed by 10 minutes of hypoxia using a gas tank with 10% oxygen, balance nitrogen (Airgas, Milwaukee, Wisconsin, USA). Gas flowed into the Buxco apparatus at a rate of 5 cc/min using a two-stage regulator for medical gas CGA973 (Airgas, Milwaukee, Wisconsin, USA). The following measurements were obtained: tidal volume (TV), minute ventilation (MV), ratio of time to peak expiratory flow over total expiratory time (Rpef), peak-inspiratory flow (PIF), peak-expiratory flow (PEF), respiratory frequency (RF), time of inspiration (Ti), time of expiration (Te), end-inspiratory pause (EIP), and end-expiratory pause (EEP).

Alvarez-Argote J., Dlugi T., Sundararajan T., Kleynerman A., Faber M., Mckillop W., & Medin J. (2023). Pathophysiological characterization of the Townes mouse model for sickle cell disease. Translational Research, 254, 77-91.

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Murine Respiratory Function Measurement

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Respiratory function was tested in unrestrained mice using a whole-body plethysmograph (Buxco Respiratory Products, Data Sciences International, St. Paul, MN). The mouse was weighed and placed into the chamber for 15 minutes to acclimate and respiratory flow data was recorded for five minutes using FinePointe software (Data Sciences International, St. Paul, MN).
The measurements were done for two consecutive days. For data analysis, average values for tidal volume (TV), minute volume (MV), TV normalized by body weight (TV/BW), and MV normalized by body weight (MV/BW) were used.

Yonekawa T., Rauckhorst A.J., El-Hattab S., Cuellar M., Venzke D., Anderson M.E., Okuma H., Pewa A.D., Taylor E.B., & Campbell K.P. (2021). Large1 Gene Transfer in Older myd Mice with Severe Muscular Dystrophy Restores Muscle Function and Greatly Improves Survival.

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