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2 5 dimethoxy 4 iodoamphetamine hydrochloride

Manufactured by Merck Group
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Sourced in Italy

(±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride is a chemical compound that can be used for research and development purposes. It is a derivative of the psychedelic drug 2,5-Dimethoxy-4-iodoamphetamine (DOI). The compound is typically used in laboratory settings for various scientific investigations.

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Lab products found in correlation

1 2 5 dimethoxy 4 iodophenyl 2 aminopropane hydrochloride, by Merck Group (2 mentions) Ketamine, by Merck Group (1 mentions) Trazodone, by Merck Group (1 mentions) Ly379268, by Bio-Techne (1 mentions) 2 3 3h d aspartate, by PerkinElmer (1 mentions) Ritanserin, by Merck Group (1 mentions) Cell death elisa kit, by Roche (1 mentions) Bovine serum albumin (bsa), by Thermo Fisher Scientific (1 mentions) Tunel kit, by Merck Group (1 mentions) Insulin transferrin selenium, by Thermo Fisher Scientific (1 mentions) Penicillin streptomycin, by Thermo Fisher Scientific (1 mentions) Mk 801 hydrogen maleate, by Merck Group (1 mentions) Naloxone hydrochloride dihydrate, by Merck Group (1 mentions) Skf38393 hydrobromide, by Bio-Techne (1 mentions) Morphine sulphate pentahydrate, by Merck Group (1 mentions) Ly341495 disodium salt, by Bio-Techne (1 mentions) R apomorphine hydrochloride hemihydrate, by Merck Group (1 mentions)

3 protocols using 2 5 dimethoxy 4 iodoamphetamine hydrochloride

1

Radiolabeled Aspartate Binding Assay

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[2,3-3H]D-aspartate (specific activity 11.3 Ci/mmol) was from Perkin Elmer (NET581001MC, Boston, MA, USA). LY379268 was purchased from Tocris Bioscience (2453, Bristol, UK). (±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride, (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride [(±) DOI], MDL11,939, ketamine, and trazodone were purchased from Sigma (Milan, Italy).
Taddeucci A., Olivero G., Roggeri A., Milanese C., Giorgio F.P., Grilli M., Marchi M., Garrone B, & Pittaluga A. (2022). Presynaptic 5-HT2A-mGlu2/3 Receptor–Receptor Crosstalk in the Prefrontal Cortex: Metamodulation of Glutamate Exocytosis. Cells, 11(19), 3035.
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2

Neural Stem Cell Culture and Analysis

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The sources of reagents are listed below. Dulbecco’s modified Eagle Medium (DMEM)/Ham’s F12 and F15 medium, Insulin-Transferrin-Selenium, 7.5% bovine serum albumin, platelet derived growth factor (PDGF)-AA, basic fibroblast growth factor (bFGF), penicillin/streptomycin, 2.5% trypsin, neurobasal medium (NBM) and B27 supplement: Invitrogen (Carlsbad, CA). Ciliary neurotrophin factor (CNTF), progesterone, triiodothyronine, biotin, putrescine, cysteine, hydrocortisone, and 5-HT2 receptor agonist 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride, (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride (DOI), 5-HT2A receptor antagonist, ritanserin: Sigma (St. Louis, MO). Terminal deoxynucleotidyl transferase mediated dUTP Nick End Labeling (TUNEL) kit: Millipore (Billerica, MA). Cell Death ELISA kit: Roche (Indianapolis, IN). Antibodies used in this study are listed in table 1.
Fan L.W., Bhatt A., Tien L.T., Zheng B., Simpson K.L., Lin R.C., Cai Z., Kumar P, & Pang Y. (2015). Exposure to serotonin adversely affects oligodendrocyte development and myelination in vitro. Journal of neurochemistry, 133(4), 532-543.
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3

Pharmacological Agents for Neural Research

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(±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride (DOI), (+)-MK801 hydrogen maleate (dizocilpine), and R-(−)-apomorphine hydrochloride hemihydrate, morphine sulphate pentahydrate and naloxone hydrochloride dihydrate were purchased from Sigma Aldrich; LY341495 disodium salt and (±)-SKF38393 hydrobromide were purchased from Tocris. LY404039 (pomaglumetad) was purchased from Selleckchem. All drugs were dissolved in saline (0.9% NaCl) to the appropriate volume (0.005–0.01 ml/g body weight) and concentration for administration (i.p.). Vehicle-treated condition denotes injection of saline (i.p.) to the equivalent volume of the drug administered.
de la Fuente Revenga M., Shin J.M., Vohra H.Z., Hideshima K.S., Schneck M., Poklis J.L, & González-Maeso J. (2019). Fully automated head-twitch detection system for the study of 5-HT2A receptor pharmacology in vivo. Scientific Reports, 9, 14247.
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