Span 80

Manufactured by Daejung Chemicals

Sourced in Cameroon

Span 80 is a non-ionic surfactant. It is a viscous liquid used as an emulsifying agent.

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Lab products found in correlation

Tween 80, by Daejung Chemicals (4 mentions) Span 20, by Daejung Chemicals (3 mentions) Fetal bovine serum (fbs), by Thermo Fisher Scientific (2 mentions) 3 4 5 dimethylthiazol 2 yl 2 5 diphenyltetrazolium bromide mtt, by Merck Group (2 mentions) Capryol 90, by Gattefosse (2 mentions) Peceol, by Gattefosse (2 mentions) Transcutol p, by Gattefosse (2 mentions) Labrasol, by Gattefosse (2 mentions) Soybean oil, by Daejung Chemicals (2 mentions) Corn oil, by Daejung Chemicals (2 mentions) Peg 400, by Daejung Chemicals (2 mentions) Direct q, by Merck Group (1 mentions) Tween 80, by Samchun (1 mentions) Dulbecco s modified eagle s medium dmem, by Thermo Fisher Scientific (1 mentions) Penicillin streptomycin, by Thermo Fisher Scientific (1 mentions) Methylene blue, by Merck Group (1 mentions) Trypan blue, by Merck Group (1 mentions) Cholesterol, by MedChemExpress (1 mentions) Triethylamine, by Merck Group (1 mentions) Cremophor el, by Merck Group (1 mentions)

Spelling variants of this product

Sorbitan monooleate 80 (Span 80) (2 citations)

7 protocols using span 80

Nanoparticle Formulation with Surfactants

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Naproxen (Nap) was purchased from Alborz bulk Co. (Tehran, Iran). Tween 80 (Samchun Pure Chemical Co., Ltd. Korea), Span 80 (Daejung Chemicals & Metals Co., Ltd. Korea), glyceryl mono stearate (GMS, (Merck Co.,Germany)) were used. Distilled water was purified using a Milli-Q system (Millipore, Direct-Q).

Akbari J., Saeedi M., Morteza-Semnani K., Rostamkalaei S.S., Asadi M., Asare-Addo K, & Nokhodchi A. (2016). The design of naproxen solid lipid nanoparticles to target skin layers. Colloids and surfaces. B, Biointerfaces, 145.

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Manganese Sulfate-based Nanoparticle Synthesis

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MnSO₄ (MnSO₄·H₂O) was acquired from TMC Co., Ltd. (Anyang, Republic of Korea). PEG 6000 was provided by Samchun Pure Chemical Co., Ltd. (Pyeongtaek, Republic of Korea). Span 80 and Tween 80 were purchased from Daejung Chemical & Metals Co., Ltd. (Siheung, Republic of Korea). 2′,7′-Dichlorofluorescin diacetate (DCFH-DA), 3,3′,5,5′-tetramethylbenzidine dihydrochloride hydrate (TMB DH), and methylene blue (MB) were purchased from Sigma–Aldrich (Saint Louis, MO, USA). Dulbecco’s modified Eagle’s medium (DMEM), penicillin-streptomycin, and fetal bovine serum (FBS) were obtained from Gibco Life Technologies, Inc. (Grand Island, NY, USA).

Jeong D.I., Kim S., Koo J.S., Lee S.Y., Kim M., Kim K.Y., Azad M.O., Karmakar M., Chu S., Chae B.J., Kang W.S, & Cho H.J. (2023). Manganese Sulfate Nanocomposites Fabricated by Hot-Melt Extrusion for Chemodynamic Therapy of Colorectal Cancer. Pharmaceutics, 15(7), 1831.

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Cytotoxicity Evaluation of DXL Formulations

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In this experimental study, DXL was received from Arasto Pharmaceutical Chemicals Inc. (Iran). Chloroform, dimethyl sulfoxide (DMSO), ethanol absolute, and high-performance liquid chromatography (HPLC). Grade acetonitrile were purchased from Scharlau (Spain). Span 20 and Span 80 were received from Daejung (Korea). 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and trypan blue were purchased from Sigma (USA). Cholesterol was from MedChem Express (China). MDA-MB-231 (epithelial, human breast cancer, National Center for Biotechnology Information (NCBI) C578), Calu-6 (renin-expressing human pulmonary adenocarcinoma, NCBI C431) and AsPC-1 (human pancreatic tumor, NCBI C558) cell lines were received from Pasteur Institute Cell Bank of Iran. Roswell Park Memorial Institute-1640 (RPMI 1640) was received from Shell max (Iran). Fetal bovine serum (FBS) was purchased from Gibco (USA). Penicillin-streptomycin solution was from Danesh Azma Cell (Iran).

Ajdari M., Ranjbar A., Karimian K., Karimi M., Heli H, & Sattarahmady N. (2024). Characterization and Evaluation of Nano-niosomes Encapsulating Docetaxel against Human Breast, Pancreatic, and Pulmonary Adenocarcinoma Cancer Cell Lines. Journal of Biomedical Physics & Engineering, 14(2), 159-168.

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Sorafenib Tosylate Formulation Development

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Sorafenib tosylate was purchased from BIOSYNTH Carbosynth (Compton, Newbury, United Kingdom). Cremophor EL, tetraglycol, triethylamine, and polyvinylpyrrolidone (PVP K 30) (average molecular weight 40 kDa) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Triacetin, isopropyl myristate (IPM), soybean oil, corn oil, tween 80, span 80, span 20, mineral oil, and glycerin were acquired from Daejung Chemicals Co. (Siheung, South Korea). Peceol, labrafil M 1994 CS, labrafil M 2125, labrasol, transcutol P, lauroglycol 90, capryol 90, and labrafac lipophile WL 1349 were obtained from Gattefossé (Saint-Priest Cedex, France). Capmul MCM and captex 355 were gifted from Abitec Corporation (Columbus, OH, USA). Propylene glycol, tween 20, olive oil, and phosphoric acid were purchased from Duksan Pure Chemical (Ansan, South Korea). Polyethylene glycol (PEG) 400 was purchased from Samchun Pure Chemical (Gyeonggi-Do, South Korea). Colloidal silica (Aerosil^® 200 Pharma) was purchased from Evonik industries AG (Essen, Germany). Ethanol (EtOH) and high-performance liquid chromatography (HPLC)-grade acetonitrile (ACN) were purchased from Honeywell Burdick & Jackson^® (Muskegon, MI, USA). All other chemicals used were of the analytical grade.

Fakhrai H., Dorigo O., Shawler D.L., Lin H., Mercola D., Black K.L., Royston I, & Sobol R.E. (1996). Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy.. Proceedings of the National Academy of Sciences of the United States of America, 93(7), 2909-2914.

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Development and Characterization of Lipid-based Formulations

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OLA was supplied by ScinoPharm Taiwan Ltd. (Tainan, Taiwan). Labrafil^® M 1944 CS, Labrafac^® PG, Labrasol^®, Transcutol^® HP and Plurol Oleique^® CC 497 were supplied by Gattefosse (St. Priest, France). Cotton seed oil, Span 80, isopropyl myristate and PEG 400 were obtained from Daejung Co. Ltd. (Siheung, Republic of Korea). Oleic acid and Tween 80 were purchased from Duksan Co. Ltd. (Ansan, Republic of Korea). Mineral oil, Capmul^® MCM EP/NF and Kolliphor^® EL (known as Cremophor EL) were obtained from Samchun Chemicals Co. (Pyeongtaek, Republic of Korea), ABITEC Corp. (Columbus, OH, USA) and BASF (Ludwigshafen, Germany), respectively. MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) was purchased from Sigma-Aldrich Co. (St. Louis, MO, USA). All chemicals and solvents used were of reagent or HPLC grade.

Kim Y.H., Kim S.B., Choi S.H., Nguyen T.T., Ahn S.H., Moon K.S., Cho K.H., Sim T.Y., Heo E.J., Kim S.T., Jung H.S., Jee J.P., Choi H.G, & Jang D.J. (2023). Development and Evaluation of Self-Microemulsifying Drug Delivery System for Improving Oral Absorption of Poorly Water-Soluble Olaparib. Pharmaceutics, 15(6), 1669.

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Lipid-Based Formulation Development and Evaluation

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MTX was purchased from Huzhou Zhanwang Pharmaceutical Co. (Huzhou, China). Capryol 90, Peceol, Plurol^® diisostearique, Transcutol P, and Labrasol were obtained from Gattefosse (Saint-Priest Cedex, France). Peanut oil, corn oil, soybean oil, sesame oil, castor oil, cotton seed oil, Span 80, and Tween^® 80 were purchased from Daejung Chemical Co. (Siheung, South Korea). Coconut oil, linseed oil, mineral oil, and olive oil were purchased from Samchun Chemical Co. (Pyeongtaek, South Korea). Cremophor EL and Cremophor RH40 were obtained from BASF (Ludwigshafen, Germany). Calcium silicate was supplied by Hanmi Pharm. Co. (Suwon, South Korea). All other chemicals and solvents were of reagent grade and were used without further purification.

Kim D.S., Cho J.H., Park J.H., Kim J.S., Song E.S., Kwon J., Giri B.R., Jin S.G., Kim K.S., Choi H.G, & Kim D.W. (2019). Self-microemulsifying drug delivery system (SMEDDS) for improved oral delivery and photostability of methotrexate. International Journal of Nanomedicine, 14, 4949-4960.

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Formulation and Evaluation of Glimepiride Nanoemulsions

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Glimepiride (GMP) was obtained as a gift from Saffron Chemical Industries Ltd. (Pakistan). Tween 20, Tween 40, Tween 80, Span 20, Span 80, propylene glycol, and PEG-400 were purchased from Daejung (Korea), whereas Labrafil-M 2125 CS, Capryol 90, and Gelucire 44/16 were gifted by Gatefosse (France). Ethanol, butanol, propanol, and glycerol were obtained from Merck (Pakistan). Clove oil, eucalyptus oil, peppermint oil, sandalwood oil, cinnamon oil, sesame oil, black seed oil, and rosemary oil were procured from Co Natural and Go Natural (Pakistan). The other chemicals and reagents used in this study were of analytical grade.

Razzaq F.A., Asif M., Asghar S., Iqbal M.S., Khan I.U., Khan S.U., Irfan M., Syed H.K., Khames A., Mahmood H., Ibrahim A.Y, & El Sisi A.M. (2021). Glimepiride-Loaded Nanoemulgel; Development, In Vitro Characterization, Ex Vivo Permeation and In Vivo Antidiabetic Evaluation. Cells, 10(9), 2404.

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