Biie024643

Manufactured by Bio-Techne

BIIE024643 is a lab equipment product manufactured by Bio-Techne. It is designed for laboratory use, but a detailed description of its core function cannot be provided without potentially introducing bias or extrapolation.

Automatically generated - may contain errors

Lab products found in correlation

Adenosine, by Merck Group (2 mentions) Glucagon, by Merck Group (2 mentions) Glp 1, by Merck Group (2 mentions)

2 protocols using biie024643

Synthesis of Chimeric Peptides

Check if the same lab product or an alternative is used in the 5 most similar protocols

Novel
chimeric peptides (GEP44 and EP series)
were produced by Genscript (Piscataway, NJ) or in-house using a microwave
assisted CEM liberty Blue peptide synthesizer. Peptides were synthesized
with C-terminal amidation and K12-azido modification (in place for
future bioconjugations) and confirmed for sequence via MS/MS and purity
by RP-HPLC (all at least >95%) (Figure S4–S9). GLP-1, glucagon, Ex-4, Ex(9–39), PYY_3–36, and adenosine were obtained from Sigma-Aldrich. BIIE024643 was
obtained from Tocris Biosciences (Minneapolis, MN).

Milliken B.T., Elfers C., Chepurny O.G., Chichura K.S., Sweet I.R., Borner T., Hayes M.R., De Jonghe B.C., Holz G.G., Roth C.L, & Doyle R.P. (2021). Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis. Journal of Medicinal Chemistry, 64(2), 1127-1138.

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Synthesis and Characterization of Chimeric Peptides

Check if the same lab product or an alternative is used in the 5 most similar protocols

Novel chimeric peptides (GEP44 and EP series) were produced by Genscript (Piscataway, NJ) or in-house using a microwave assisted CEM liberty Blue peptide synthesizer. Peptides were synthesized with C-terminal amidation and K12-azido modification (in place for future bioconjugations) and confirmed for sequence via MS/MS and purity by RP-HPLC (all at least >95%) (Figure S4–S9). GLP-1, glucagon, Ex-4, Ex(9–39), PYY_3–36, and adenosine were obtained from Sigma-Aldrich. BIIE024643 was obtained from Tocris Biosciences (Minneapolis, MN).

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