Delphi w instrument

Eleven nonobese healthy men (BMI 23–29.9 kg/m²) aged 25–45 years and not highly trained (<5 h of moderate intensity, planned exercise per week) completed this randomized placebo controlled cross‐over study. Subjects were recruited between 2009 and 2013 for participation by responding to advertisements from the University of Colorado Anschutz Medical Campus (Table 1). The study was approved by the Colorado Multiple Institutional Review Board (COMIRB) and informed written consent was obtained from all participants prior to enrolling in the study. All clinical investigations were conducted according to the principles expressed in the Declaration of Helsinki.
Preliminary assessments were completed at the Clinical and Translational Research Center (CTRC) at the University of Colorado Anschutz Medical Campus. At baseline, all subjects underwent a physical examination and biochemical testing to exclude medical illness. Specific exclusions included past or present history of cardiovascular disease, high blood pressure, diabetes, hormonal imbalance and/or metabolic abnormality, medications known to affect weight or lipid metabolism, and body weight change of 5% or greater in the past 6 months. Body composition was measured at baseline using dual energy X‐ray absorptiometry (Hologic Delphi‐W instrument, Waltham, MA).

Dual-energy X-ray absorptiometry (DXA) scans were performed of the lumbar spine (L1–L4), left hip, and left proximal femur at both centres. At Vestfold Hospital Trust, all patients were examined with a Hologic^® Delphi W instrument (Hologic^®, Bedford, MA, USA); at Oslo University Hospital, a GE Lunar Prodigy (General Electric Company^©, Chicago, IL, USA)was used until 26 August 2016, when it was replaced by a GE Lunar iDXA. Cross-calibration of the two DXA scanners has been published previously¹³ (link). Areal bone mineral density (aBMD), t-scores, and z-scores were calculated with enCore version 17 software (GE Medical Systems^©, Madison, WI, USA) based on a large database of reference populations from the NHANES I–III and Lunar studies provided by the manufacturer. The database contains data from healthy adults and allows correction of measured values based on age, sex, and ethnicity¹⁴ .