The DAGLα and β inhibitor DO34 was generously donated by Dr. van der Stelt (Leiden University, Leiden, The Netherlands) and also purchased from Aobious Inc. (Gloucester, MA, USA), The MAGL inhibitor MJN110, the CB1 receptor (CB1R) antagonist AM281, the CB2R antagonist AM630, and the deuterated AEA, 2-AG and arachidonic acid (AEA-d4, 2-AG-d5 and AA-d8) were purchased from Cayman Chemicals (Ann Arbor, MI, USA).
Mjn110
Manufactured by Cayman Chemical
Sourced in United States
The MJN110 is a laboratory equipment product manufactured by Cayman Chemical. It is designed to perform specific functions in a research or analytical setting. The core function of the MJN110 is to [core function description]. Further details on the intended use or applications of this product are not provided.
Automatically generated - may contain errors
Lab products found in correlation
Am281, by Cayman Chemical (1 mentions)
Am630, by Cayman Chemical (1 mentions)
2 ag d5, by Cayman Chemical (1 mentions)
Aa d8, by Cayman Chemical (1 mentions)
Sr141716, by Cayman Chemical (1 mentions)
Ketamine xylazine, by Merck Group (1 mentions)
Sr144528, by Cayman Chemical (1 mentions)
Kt 182, by Cayman Chemical (1 mentions)
M5310, by Merck Group (1 mentions)
3 protocols using mjn110
1
Cannabinoid Inhibitor Synthesis and Assay
2
Pharmacological Agents for Animal Studies
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Ketamine/xylazine was purchased from Sigma-Aldrich (St. Louis, MO) and isoflurane from VetOne. (IL, USA). MJN110, KT-182, SR141716 (Rimonabant), and SR144528 were purchased from Cayman Chemicals (Ann Arbor, MI). All other chemicals, unless noted were purchased from Sigma-Aldrich (St. Louis, MO).
3
Hepatotoxicity Modulation by MAGL Inhibitor
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Ten- to 16-week-old male mice received one intraperitoneally (i.p.) injection (0.6 ml/kg body weight [BW]) of carbon tetrachloride (CCl4) (Sigma-Aldrich 87030) diluted 1/10 in mineral oil (Sigma-Aldrich M-5310). Control animals received mineral oil. When indicated, mice were i.p. injected with the MAGL inhibitor MJN110 (Cayman Chemical 17583), or its vehicle (Emulphor:ethanol:PBS 1:1:18, 10 mg/kg BW), 2 h before CCl4 injection and then daily until sacrifice. When indicated, anti-mouse interferon ɑ/β receptor (IFNAR) 1 antibody (Bio Cell BE0241), or its isotype (Bio Cell BE0083), was injected i.p. the day before CCl4 injection (500 μg), 1 h before CCl4 injection (450 μg), and 24 h after CCl4 injection (250 μg) as described in a previous study,10 (link) and animals were sacrificed 48 h after CCl4 injection.
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