Mettler stare system

DSC analyses were performed with a Mettler STAR^e system (Mettler Toledo, Novate Milanese, MI, Italy) equipped with a DSC821^e Module and an Intracooler device for sub-ambient temperature analysis (Julabo FT 900) on 2–3 mg (Mettler M3 Microbalance) samples in sealed aluminum pans with pierced lid (heating rate β = 10 K min⁻¹, nitrogen air atmosphere (flux 50 mL min⁻¹), 30–300 °C temperature range)). The instrument was previously calibrated with Indium as standard reference. Measurements were carried out at least in triplicate.

Mass losses were recorded with a Mettler STAR^e system (Mettler Toledo, Novate Milanese, MI, Italy) TGA with simultaneous DSC (TGA/DSC1) on 4–6 mg samples in alumina crucibles with lid [β = 10 K min⁻¹, nitrogen air atmosphere (flux 50 mL min⁻¹), 30–350 °C temperature range]. The instrument was previously calibrated with indium as standard reference and measurements were carried out at least in triplicate.

DSC curves were recorded using a Mettler STAR system (Mettler Toledo, Milan, Italy) equipped with a DSC821^e Module and an Intracooler device for sub-ambient temperature analysis (Julabo FT 900) on 2–3 mg (Mettler M3 Microbalance) samples placed in sealed aluminum pans with a pierced lid, in the heating range of 30–300 °C [heating rate β = 10 K·min⁻¹, nitrogen air atmosphere (flux 50 mL·min⁻¹)]. High purity indium metal was used as a standard reference for the instrument calibration. Measurements were carried out at least in triplicate. Mass losses were recorded with a Mettler STAR^e system (Mettler Toledo, Milan, Italy) TGA with simultaneous DSC (TGA/DSC1) on 3–4 mg samples in alumina crucibles with a lid [heating rate β = 10 K·min⁻¹, nitrogen air atmosphere (flux 50 mL·min⁻¹), 30–300 °C temperature range]. The instrument was previously calibrated with indium as a standard reference and measurements were carried out at least in triplicate.

Mass losses were recorded with a Mettler STAR^e system (Mettler Toledo, Novate Milanese, MI, Italy) TGA with simultaneous DSC (TGA/DSC1) on 3–4 mg samples in alumina crucibles with lid (heating rate β = 10 K min⁻¹, nitrogen air atmosphere (flux 50 mL min⁻¹), 30–300 °C temperature range). The instrument was previously calibrated with Indium as standard reference and measurements were carried out at least in triplicate.

GG/RC-33 IP, formed in the dialysis bag in presence of 10 mg/mL RC-33, was dried at 50 °C for three days and subjected to a solid-state characterization in comparison with GG and RC-33.
Differential scanning calorimetry (DSC) analysis (10–300 °C, heating rate β = 10 K min⁻¹, nitrogen air atmosphere (flux 50 mL min⁻¹)) was performed by means of Mettler STAR^e thermal analysis system, version 9.30 DSC821^e (Mettler Toledo, Milan, Italy), equipped with an Intracooler device for sub-ambient temperature analysis (Julabo FT 900). Three replicates were performed for each sample.
Thermogravimetric analysis (TGA) (30–300 °C, heating rate β = 10 K min⁻¹, nitrogen air atmosphere (flux 50 mL min⁻¹), temperature range) was carried out by means of a Mettler STAR^e system (Mettler Toledo, Milan, Italy). Three replicates were performed for each sample.
Fourier-transform infrared spectroscopy (FT-IR) spectra were recorded using a FT-IR spectrophotometer (Perkin Elmer Spectrum One, Monza, Italy) with a single reflection attenuated total reflectance (ATR) accessory (PIKE MIRacle™). Approximately 5 mg of each sample (RC-33, GG and RC-33/GG IP) were placed on ATR crystal of ZnSe and pressed down to the crystal. The scanning range was 650–4000 cm⁻¹ and the resolution was 4 cm⁻¹.

For the binary systems investigated, temperature and enthalpy values were measured with a Mettler STAR^e system (Mettler Toledo, Novate Milanese, MI, Italy) equipped with a DSC821^e Module and an Intracooler device for sub-ambient temperature analysis (Julabo FT 900) on 2–4 mg (Mettler M3 Microbalance) samples in sealed aluminium pans with pierced lid [heating rate β = 10 K min⁻¹, nitrogen atmosphere (flux 50 mL min⁻¹), 30–350 °C temperature range)]. The instrument was previously calibrated with indium as standard reference. Measurements were carried out at least in triplicate. For co-precipitated, crystalline products, traces were recorded on a DSC-Q200 differential scanning calorimeter with samples in closed aluminium pans heated at 10 K min⁻¹ and dry nitrogen purge gas flowing at 50 mL min⁻¹. TG traces for these products were recorded on samples in alumina crucibles using a TA-Q500 instrument under similar conditions as for the DSC measurements.