Dissolution experiments were conducted in triplicate with 25 mg drug substance or an equivalent amount of ASD using USP apparatus II (DT 800 LH) from ERWEKA GmbH (Langen, Germany). The paddle speed was set to 100 rpm to avoid coning effects and all experiments were performed in 500 mL of 0.1 M hydrochloric acid at 37 ± 0.5 °C. The test duration was 120 min. All samples were withdrawn by a fraction collector, equipped with poroplast cannula filters of 10 µm pore size and manually diluted 1:1 (v/v) with acetonitrile, before HPLC analysis.
Usp apparatus 2 dt 800 lh
Manufactured by Erweka
Sourced in Germany
The USP Apparatus II (DT 800 LH) is a dissolution testing device designed for the evaluation of drug release from solid oral dosage forms. It features a paddle-style stirring mechanism and a temperature-controlled water bath to maintain the required temperature during the testing process. The apparatus is intended to be used in accordance with the United States Pharmacopeia (USP) standards for dissolution testing.
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Lab products found in correlation
2 protocols using usp apparatus 2 dt 800 lh
1
In Vitro Dissolution of Drug Substance
2
Dissolution Experiments of Celecoxib SNEDDS
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Dissolution experiments were performed with 25 mg celecoxib or an equivalent amount of L-/S-SNEDDS using USP apparatus II (DT 800 LH) from ERWEKA GmbH (Langen, Germany). The paddle speed was set to 100 rpm to avoid coning effects and the experiments were performed in 500 ml of 0.1 N hydrochloric acid (HCl) as well as in 500 ml of phosphate buffer 6.8 USP, both maintained at 37 ± 0.5°C.
Samples were withdrawn via a fraction collector, equipped with poroplast cannula filters with a pore size of 10 μm, and were then diluted 1+1 (v/v) with acetonitrile and analyzed by HPLC.
Samples were withdrawn via a fraction collector, equipped with poroplast cannula filters with a pore size of 10 μm, and were then diluted 1+1 (v/v) with acetonitrile and analyzed by HPLC.
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