Vinblastine

Manufactured by MedChemExpress

Sourced in United States

Vinblastine is a laboratory product available from MedChemExpress. It is a natural compound derived from the periwinkle plant. Vinblastine functions as a mitotic inhibitor, disrupting the formation of microtubules during cell division.

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Lab products found in correlation

3 protocols using vinblastine

Chemotherapeutic Agents Procurement Protocol

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Chemotherapeutic agents were purchased from different sources: cisplatin (Vnr461201, Accord Healthcare, UK), methotrexate (M9929, Sigma Aldrich, St. Louis, MO, USA), irinotecan hydrochloride (AB252173, abcr, Karlshure, Germany), doxorubicin hydrochloride (25316-40-9, Sigma Aldrich, United States), vinblastine (HY-13780, MedChemExpress, Monmouth Junction, NJ, USA), TPEN (P4413, Tocris, Bristol, UK), nutlin-3 (3984, Tocris, UK), mitoxantrone (M2305000, Sigma Aldrich, UK), and bendamustine was a kind gift from Servier.

Vajda F., Szepesi Á., Várady G., Sessler J., Kiss D., Erdei Z., Szebényi K., Német K., Szakács G, & Füredi A. (2022). Comparison of Different Clinical Chemotherapeutical Agents’ Toxicity and Cell Response on Mesenchymal Stem Cells and Cancer Cells. Cells, 11(19), 2942.

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Modulation of Cholinergic Receptors in LPS-Induced Model

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The peripheral mAChR agonist Arecoline hydrobromide, mAChR antagonist Methylbenactyzium bromide, and nAChR agonist Monepantel, nAChR antagonist Vinblastine were obtained from MedChem Express (New Jersey, USA). The α7nAChR agonists AR-R17779 hydrochloride and GTS-21, antagonist Methyllycaconitine citrate were also purchased from MedChem Express (New Jersey, USA. The reagents were administered 4 hours after LPS instillation once (5 mg/kg dose of the reagents). Stored at −20 ^oC, all the reagents were diluted in saline to the final concentration and were injected intraperitoneally.

Zhang X., Wei X., Deng Y., Yuan X., Shi J., Huang W., Huang J., Chen X., Zheng S., Chen J., Chen K., Xu R., Wang H., Li W., Li S., Yi H, & Xiang A.P. (2022). Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway. Signal Transduction and Targeted Therapy, 7, 307.

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Screening Spectrum Collection Compounds for OATP1B1 Inhibition

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Compounds from the Spectrum Collection, distributed in 80 wells of 96 well plates (100 nmol per well in 10 μl of DMSO), were screened for their inhibitory effectiveness against transport of E3S into CHO cells expressing OATP1B1; a total of 560 compounds were used. Each compound was diluted to a concentration of 20 μM, pH 7.4, to a final concentration of 2% dimethylsulfoxide (DMSO) using a VIAFLO multichannel electronic pipet (Integra Biosciences, Hudson, NH) ⁶⁵. The following compounds for prospective testing were purchased from MedChemExpress (Monmouth Junction, NJ): abamectin, asiaticoside, baloxavir, berbamine, bremelanotide, bromocriptine, cabazitaxel, doramectin, etoposide, lapatinib, mobocertinib, novobiocin, posaconazole, rifaximin, teniposide, umbralisib, vancomycin, vinblastine and vincristine. Pyronaridine tetraphosphate was purchased from BOC Sciences (Shirley, NY) and tilorone hydrochloride from Caymen Chemical Company (Ann Arbor, MI). These compounds were solubilized in DMSO at 20 mM prior to tested.

Lane T.R., Urbina F., Zhang X., Fye M., Gerlach J., Wright S.H, & Ekins S. (2022). Machine Learning Models Identify New Inhibitors for Human OATP1B1. Molecular pharmaceutics, 19(11), 4320-4332.

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