The hospital laboratory measured blood eosinophil counts during the hospitalization with a Automated hematology analyzer XNseries by SYSMEX CORPORATION. These blood samples were obtained from the patients in the first 24 h after admission.
Xn series
Manufactured by Sysmex
Sourced in Japan, Germany
The XN series is a line of automated hematology analyzers developed by Sysmex. The core function of the XN series is to analyze various blood parameters, including red blood cells, white blood cells, and platelets, providing comprehensive data for clinical assessment.
Automatically generated - may contain errors
Lab products found in correlation
Au5800, by Beckman Coulter (1 mentions)
Cs 5100, by Sysmex (1 mentions)
Cobas c702 analyzer, by Roche (1 mentions)
Cobas 6000 analyzer, by Roche (1 mentions)
Advia 2120i, by Siemens (1 mentions)
Alinity c, by Abbott (1 mentions)
Voluson e8, by GE Healthcare (1 mentions)
Vitek 2 compact, by bioMérieux (1 mentions)
20 protocols using xn series
1
Eosinophil Measurement in Hospitalized Patients
2
Breast Cancer Radiation Therapy Protocol
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Body weight and height of the enrolled patients were measured on their first visit or on admission for breast operation. All measurements were taken prior to any treatment for breast cancer. BMI was calculated by dividing body weight (kilogram) by the square of height (meter), as defined by the World Health Organization20 . When we used categorical BMI, we divided the enrolled patients into two groups based on BMI: (i) high (BMI ≥ 25.0 kg/m2) and (ii) normal weight (BMI < 25.0 kg/m2)20 .
Peripheral blood samplings were taken at baseline, two weeks prior to RT (pre-ALC) and one week before the last RT lesion (post-ALC). White blood cells and differential counts were evaluated at the Department of Laboratory Medicine using an automated counting machine (Sysmex XN-Series; Kobe, Japan). The pre- and post-ALCs were determined using differential counts, and the pre-to-post ALC ratio was obtained.
Radiation was administered according to the following protocol: 50.4 Gy of radiation was administered in 28 fractions using X-ray linear accelerators (Elekta; Stockholm, Sweden) to the whole breast, followed by a boost dose of 9 Gy in 5 fractions delivered to the tumor bed. A few patients were treated with hypofractionated RT (5/532, 0.9%). In cases with positive axillary lymph nodes or suspicious internal mammary lymph nodes, RNI was delivered simultaneously.
Peripheral blood samplings were taken at baseline, two weeks prior to RT (pre-ALC) and one week before the last RT lesion (post-ALC). White blood cells and differential counts were evaluated at the Department of Laboratory Medicine using an automated counting machine (Sysmex XN-Series; Kobe, Japan). The pre- and post-ALCs were determined using differential counts, and the pre-to-post ALC ratio was obtained.
Radiation was administered according to the following protocol: 50.4 Gy of radiation was administered in 28 fractions using X-ray linear accelerators (Elekta; Stockholm, Sweden) to the whole breast, followed by a boost dose of 9 Gy in 5 fractions delivered to the tumor bed. A few patients were treated with hypofractionated RT (5/532, 0.9%). In cases with positive axillary lymph nodes or suspicious internal mammary lymph nodes, RNI was delivered simultaneously.
3
Comprehensive Immunological Profiling Protocol
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For complete blood cell count, electrical resistance method and a flow cytometric method were used, and their differential was evaluated by XN-Series (Sysmex). A latex aggregation test was used for C-reactive protein measurement, and C1q-binding immune complexes levels were evaluated by ELISA. C3 and C4 were quantified by immunonephelometric assays and CH50 was measured by liposome immunoassay. Anti-dsDNA antibodies were measured by fluoroenzyme immunoassay (FEIA) method, with the manufacturer’s cut-off value of 10 U/mL.
4
Survival Prediction in Liver Disease
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Relevant demographic and clinical data of the patients were obtained from medical records. Total protein, albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, creatinine, and blood urea nitrogen were measured in a Beckman Coulter AU5800 analyzer (Beckman Coulter, United States). Routine blood tests including hemoglobin levels, white blood cell (WBC), monocyte, and platelet (PLT) count were measured in a Sysmex XN series automated hematology analyzer (Sysmex, Japan). A Sysmex CS5100 automated blood coagulation analyzer (Sysmex, Japan) was used to determine the coagulation indices that included the international normalized ratio (INR). The PMR was defined as PLT divided by monocyte. Severity of liver disease was evaluated at the time of admission by the Model for End-Stage Liver Disease (MELD) score as previously described [20 (link)]. Patients were followed for 30 days to evaluate survival. Data on mortality were obtained from medical records or by telephone.
5
Fasting Blood Biomarker Measurements
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Participants were required to fast for at least 8 h prior to blood tests. Fasting blood samples were sent to the National University Hospital Laboratory for measurements of the following: full blood count, glucose, lipid panel and creatinine. Haemoglobin was measured with the Sysmex XN-Series automated haematology analyser 2012 version (Streck, Omaha, NE, USA). The lipid panel comprised total cholesterol, low-density lipoprotein, high-density lipoprotein and triglyceride levels.
6
Pancreatic Mass Diagnostic Biomarkers
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Demographic data, pathological information, diabetes mellitus status, and laboratory test results (CK, CK-MB, albumin, absolute neutrophil count, absolute lymphocyte count, and CA19-9) were collected for all patients diagnosed with a pancreatic mass (missing values were estimated using the median value of the corresponding group, including 1 CA19-9 value in the PC group and 3 CA19-9 values in the benign pancreatic mass group). The same information was collected and recorded for the control group, except for pathological data and tumor marker levels. Blood samples were obtained before the operation. Blood was collected for albumin, CK, and CK-MB testing in the morning after subjects had fasted, and the levels of these parameters were measured using a Roche Cobas c 702 analyzer (Roche Diagnostics GmbH, Mannheim, Germany). CA19-9 levels were detected using a Cobas 6000 analyzer (Roche Diagnostics, Basel, Switzerland), and an automated hematology analyzer XN series (Sysmex Corporation, Japan) was used to measure routine blood cell counts. All this information was retrospectively obtained from the hospital electronic records.
7
Peripheral Blood Cell Profiling in COS
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Peripheral blood samples were collected in the time period between the diagnosis and initiation of COS cycles. The number of WBCs was determined using a hemocytometer. Percentages of different cell types in the CBC were obtained using an automated hematology analyzer XN series (SYSMEX CORPORATION, JAPAN) for all patients before COS. All measurements and processes were conducted according to the standard laboratory manual. Most of the measurements were obtained within 1 month before COS, and all values were obtained within 2 months. MPV was directly measured in the CBC while the MPV/PC ratio was calculated by dividing MPV by the platelet count (104/µL). NLR was calculated by dividing the absolute neutrophil count by the absolute lymphocyte count. PLR was calculated by dividing the absolute platelet count by the absolute lymphocyte count, and LMR was determined by dividing the absolute lymphocyte count by the absolute monocyte count.
8
Automated Hematology Analyzer Blood Analysis
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CBC measurements were obtained from EDTA-K3 peripheral blood samples analyzed by the Automated Hematology Analyzer XT or XN series from Sysmex (Sysmex Corporation, Kobe, Japan). Red blood cells (RBC) and platelets were counted and sized through direct current impedance, while hematocrit and hemoglobin levels were determined using pulse height and sodium lauryl sulfate spectrophotometry, respectively.
9
Blood Sample Collection and Analysis
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Fasting blood samples were taken by venipuncture at one of the Lifelines research sites. The blood samples were kept at 4 °C and were transported to the Lifelines laboratory in Groningen. From there, the samples were transferred without delay to the UMCG central laboratory where the routine clinical chemistry and hematological tests were performed. The whole process was tightly controlled and monitored continuously [8] . The fresh EDTA anticoagulated blood samples were analyzed within 6 h after venipuncture on one of two automated hematology analyzers (XN-series, Sysmex, Kobe, Japan).
10
Multicenter Evaluation of Hematology and Biochemistry Assays
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The results for the following haematology test parameters were collected: haemoglobin (Hb, g/L), haematocrit (Hct, %), red blood cell count (RBC, 1012/L), white cell count (WCC, 109/L) and platelet (PLT, 109/L). The XN series (Sysmex, Kobe, Japan) were used in five hospitals. Four of them used an XN-1000 analyser and one hospital used an XN-3000. ADVIA 2120i (Siemens Healthcare Diagnostics, Eschborn, Germany) was used in two hospitals.
The results for the following chemistry parameters were collected: creatinine (mg/dL), aspartate aminotransferase (AST, IU/L), alanine aminotransferase (ALT, IU/L), gamma glutamyl transferase (GGT, IU/L), total cholesterol (mg/dL), triglyceride (mg/dL), high-density lipoprotein (HDL) cholesterol (mg/dL), low-density lipoprotein (LDL) cholesterol (mg/dL) and fasting glucose. The Beckman Coulter AU series (Beckman Coulter, Miami, USA) were used to measure these biochemical parameters in seven hospitals. Of the hospitals, four, two and one used AU-480, AU-680 and AU-5800, respectively.
Routine external quality control management procedures for laboratory tests were performed under the Korean Association of External Quality Assessment Service. All hospitals performed internal quality controls and the analytical devices are calibrated in line with the instructions provided by the manufacturers.
The results for the following chemistry parameters were collected: creatinine (mg/dL), aspartate aminotransferase (AST, IU/L), alanine aminotransferase (ALT, IU/L), gamma glutamyl transferase (GGT, IU/L), total cholesterol (mg/dL), triglyceride (mg/dL), high-density lipoprotein (HDL) cholesterol (mg/dL), low-density lipoprotein (LDL) cholesterol (mg/dL) and fasting glucose. The Beckman Coulter AU series (Beckman Coulter, Miami, USA) were used to measure these biochemical parameters in seven hospitals. Of the hospitals, four, two and one used AU-480, AU-680 and AU-5800, respectively.
Routine external quality control management procedures for laboratory tests were performed under the Korean Association of External Quality Assessment Service. All hospitals performed internal quality controls and the analytical devices are calibrated in line with the instructions provided by the manufacturers.
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