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Boc lys boc oh

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Boc-Lys(Boc)-OH is a chemical compound used in organic synthesis and peptide chemistry. It is a protected amino acid derivative, where the amino and side-chain functional groups are both protected with Boc (tert-butyloxycarbonyl) protecting groups. This compound is commonly used as a building block in the synthesis of more complex peptides and molecules.

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Lab products found in correlation

Uridine triphosphate, by Merck Group (1 mentions) Milli q advantage a10 purification system, by Merck Group (1 mentions) Phosstop easypack, by Roche (1 mentions) Ammonium hydroxide nh3 h2o, by Merck Group (1 mentions) Tris 2 carboxyethyl phosphine hydrochloride tcep, by Merck Group (1 mentions) Adenosine triphosphate (atp), by Merck Group (1 mentions) Ammonium acetate nh4ac, by Merck Group (1 mentions) Methanol meoh, by Merck Group (1 mentions) Silver nitrate agno3, by Sinopharm (1 mentions) Phosphoric acid h3po4, by Sinopharm (1 mentions) Succinate anhydride, by Merck Group (1 mentions) D alpha tocopherol, by Tokyo Chemical Industry (1 mentions) Fmoc lys boc oh, by Merck Group (1 mentions) N n dicyclohexylcarbodiimide dcc, by Thermo Fisher Scientific (1 mentions) 3 4 5 dimethylthiazol 2 yl 2 5 diphenyltetrazolium bromide, by Merck Group (1 mentions) Fetal bovine serum (fbs), by Thermo Fisher Scientific (1 mentions) Trypsin edta solution, by Merck Group (1 mentions) Penicillin streptomycin solution, by Thermo Fisher Scientific (1 mentions) Triton x 100, by Merck Group (1 mentions) Dulbecco s modified eagle s medium dmem, by Merck Group (1 mentions)

2 protocols using boc lys boc oh

1

Synthesis and Characterization of Compounds

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RDV (purity ≥ 98 %), RMP (purity of 93 %), and RTP (purity of 98 %) were synthesized as previously reported [6 (link),18 (link)]. The structure and purity of each compound were identified by NMR and HPLC-UV. RN (purity of 98 %) was purchased from Target Molecule Corp. (Boston, MA, USA). Adenosine triphosphate (ATP, purity of 99 %), uridine triphosphate (UTP, purity of 96 %), 13C,15N-ATP (purity of 98 %), 5,5′-dithiobis(2-nitrobenzoic acid) (DTNB, purity ≥ 98 %), bis (p-nitrophenyl) phosphate (BNPP, purity ≥ 99 %), tris-(2-carboxyethyl)phosphine hydrochloride (TCEP, purity ≥ 98 %), Boc-Lys(Boc)-OH, ammonium hydroxide (NH3∙H2O, 28 % NH3 in H2O), and ammonium acetate (NH4Ac) were obtained from Sigma-Aldrich (St. Louis, MO, USA). PhosSTOP™ EASYpack (PhosSTOP) was purchased from Roche (Basel, Switzerland). The Invitrosol™ LC/MS Protein Solubilizer Kit was purchased from ThermoFisher (MA, USA). Phosphoric acid (H3PO4, purity ≥ 85 %) and silver nitrate (AgNO3) were obtained from Sinopharm Chemical Regent Co., Ltd. (Shanghai, China). Acetonitrile (ACN), formic acid (FA), and methanol (MeOH) were obtained from Merck (NJ, USA). Ultrapure water was obtained using a Millipore Milli-Q® Advantage A10 Purification System (Millipore, Molsheim, France). All other regents were of the highest quality commercially available.
Hu W., Chang L., Ke C., Xie Y., Shen J., Tan B, & Liu J. (2020). Challenges and stepwise fit-for-purpose optimization for bioanalyses of remdesivir metabolites nucleotide monophosphate and triphosphate in mouse tissues using LC–MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 194, 113806.
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2

Doxorubicin Nanoformulation Development

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Doxorubicin hydrochloride (98%) (DOX.HCl) was purchased from AK Scientific Inc. (CA, USA). Doxil was purchased from Avanti® Polar Lipids (AL, USA). Methoxy-PEG5,000-OH, succinate anhydride, Boc-lys-(Boc)-OH, Fmoc-lys-(Boc)-OH, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT), aspartic acid, trypsin-EDTA solution, Triton X-100, and Dulbecco’s Modified Eagle’s Medium (DMEM) were all purchased from Sigma-Aldrich (MO, USA). D-alpha-tocopherol was purchased from Tokyo Chemical Industry (OR, USA). N,N′-dicyclohexylcarbodiimide (DCC) was purchased from Alfa Aesar (MA, USA). 4-Dimethylaminopyridine (DMAP) was purchased from Calbiochem-Novabiochem Corporation (CA, USA). Fetal bovine serum (FBS) and penicillin-streptomycin solution were from Invitrogen (NY, USA). All solvents used in this study were HPLC grade.
Lu J., Zhao W., Liu H., Marquez R., Huang Y., Zhang Y., Li J., Xie W., Venkataramanan R., Xu L, & Li S. (2014). An Improved D-α-Tocopherol-Based Nanocarrier for Targeted Delivery of Doxorubicin with Reversal of Multidrug Resistance. Journal of controlled release : official journal of the Controlled Release Society, 0, 272-286.
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