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Hexadecyl isocyanate

Manufactured by Merck Group
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Hexadecyl isocyanate is a chemical compound used in various laboratory applications. It is a colorless, oily liquid with a pungent odor. The primary function of hexadecyl isocyanate is to serve as a reactant or intermediate in organic synthesis and chemical research.

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Lab products found in correlation

Methylene chloride, by Sinopharm (1 mentions) Phosphotungstic acid, by Sinopharm (1 mentions) Trichloromethane, by Sinopharm (1 mentions) Methyl thiazolyl tetrazolium (mtt), by Merck Group (1 mentions) Dichloromethane, by Sinopharm (1 mentions) Hydrogen peroxide, by Sinopharm (1 mentions) Diethyl ether, by Sinopharm (1 mentions) Palladium on carbon, by Merck Group (1 mentions) 1 2 phenylenediamine, by Merck Group (1 mentions) 2 aminophenol, by Merck Group (1 mentions) N n dimethylethylenediamine, by Merck Group (1 mentions) Ethanolamine, by Merck Group (1 mentions) Vanillin, by Merck Group (1 mentions) Hydroxylamine hydrochloride, by Merck Group (1 mentions) Anhydrous dichloromethane, by Merck Group (1 mentions) Methanol, by Avantor (1 mentions) Palmitoyl chloride, by Merck Group (1 mentions) Avance nmr, by Bruker (1 mentions) Hplc grade acetonitrile, by Avantor (1 mentions) Milli q reference system, by Merck Group (1 mentions)

3 protocols using hexadecyl isocyanate

1

Synthesis and Evaluation of PEG-Modified Nanocarrier

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PEG2k-NH2 was purchased from Xiamen SINOPEG Biotechnology Co., Ltd. (Xiamen, China). Methylene chloride, dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), dichloromethane (DCM), trichloromethane (TCM), diethyl ether, and hydrogen peroxide were purchased from Sinopharm Group Chemical Reagent Co., Ltd. (Shanghai, China). Succinic anhydride 1-ethyl-3(3-dimethylpropylamine) (EDCI) was offered by Beijing Bailingwei Technology Co., Ltd. (Beijing, China). Hexadecyl isocyanate and MTT were obtained from Sigma-Aldrich (Shanghai) Trading Co., Ltd. (Shanghai, China). Carboplatin was obtained from Shandong Boyuan Pharmaceutical Co., Ltd. (Jinan, China). St. Nile red and phosphotungstic acid were purchased from Sinopharm Group Chemical Reagent Co., Ltd. (Shanghai, China). RPMI1640 culture medium and newborn fetal bovine serum were obtained from GIBCO Biotechnology Co., Ltd. (Carlsbad, CA). H460, A549 tumor cell lines were obtained from the Institute of Basic Medicine, Chinese Academy of Medical Sciences (Beijing, China). SPF balb/c/nu/nu nude mice were provided by Viton Lihua.
Lang T., Li N., Zhang J., Li Y., Rong R, & Fu Y. (2021). Prodrug-based nano-delivery strategy to improve the antitumor ability of carboplatin in vivo and in vitro. Drug Delivery, 28(1), 1272-1280.
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2

Synthesis of Organic Compounds

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Hexadecyl chloroformate (96%), hexadecyl isocyanate (97%), N, N-dimethylethylenediamine (99%), ethanolamine (99%), 2-aminophenol (99%), 1,2-phenylenediamine (99%), palladium on carbon (10 wt%), hydroxylamine hydrochloride (99%), and vanillin (99%) were purchased from Sigma-Aldrich (Burlington, MA, USA) and used without further purification. Dichloromethane, ethyl acetate, hexane, acetone and ethyl alcohol were reagent grade from Alveg (Tlalnepantla de Baz, Mexico).
Martínez-Mejía G., Bermeo-Solórzano B.A., González S., del Río J.M., Corea M, & Jiménez-Juárez R. (2022). New Carbamates and Ureas: Comparative Ability to Gel Organic Solvents. Gels, 8(7), 440.
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3

Dexamethasone Palmitate Nanoparticle Synthesis

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Palmitoyl chloride, dexamethasone, hexadecyl isocyanate, anhydrous dichloromethane, and triethyl amine were purchased from Sigma Aldrich (France). Hexadecyl chloroformate was obtained from Tokyo Chemical Industry, Co. LT (Japan). LDC1, LDC2, and LDC3 were synthesized as described below. DSPE-PEG 2000 was obtained from Avanti Polar Lipids, Inc. (USA). MilliQ reference system from Millipore (France) was used to purify water. Chloroform HPLC-grade (Carlo Erba Reagents, France), methanol, and acetonitrile HPLC-grade (VWR Chemicals, France) were used. NMR spectra were recorded on Bruker Avance-NMR (300, and 400 MHz) spectrometers in CDCl 3 . ESI-MS of compounds were measured on Thermofisher Scientific (LTQ, ion trap, H-ESI II). All experiments were performed in amber vials due to the photosensitivity of dexamethasone palmitate [28] (link)
Ur-Rehman M., Reynaud F., Lepetre S., Abreu S., Chaminade P., Fattal E, & Tsapis N. (2023). Modulation of release and pharmacokinetics from nanoscale lipid prodrugs of dexamethasone with variable linkage chemistry. Journal of controlled release : official journal of the Controlled Release Society, 360.
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