Ge 3.0 t mr750

All participants will receive MRI scans at the baseline and at the end of the treatment. MRI data will be acquired with a 3.0-T magnetic resonance scanner (GE 3.0 T MR750; GE Healthcare, Chicago, IL, USA) at the MRI Center in University of Electronic Science and Technology of China. A comfortable sponge pad is used to fix the subject’s head to minimize head motion, and earplugs are used to attenuate noise. At the same time, all participants will be told to remain motionless, keep their eyes closed, and stay awake during the scanning. The scanning procedure contains a localizer, a high-resolution three-dimensional T1-weighted imaging (3D-T1WI), and a blood oxygenation level-dependent fMRI (BOLD-fMRI).
The scanning parameters will be as follows: 3D-T1WI—repetition time (TR)/echo time (TE) = 2000/30 ms, slice thickness = 1 mm, slice number = 1, matrix size = 128 × 128, and field of view (FOV) = 256 × 256 mm; BOLD-fMRI—TR/TE = 2000/30 ms, flip angle = 90°, slice number = 35, matrix size = 128 × 128, FOV = 240 × 240 mm, slice thickness = 4 mm, and total volume = 240.

All of the participants underwent MRI scans on a 3.0-T MRI scanner with an eight-channel phase-array head coil (GE 3.0 T MR750; GE Healthcare, Chicago, IL, USA) at the MRI Research Center of University of Electronic Science and Technology of China, Chengdu, China. During the MRI scans, all participants were instructed to keep their eyes closed and their head still. Earplugs and foam pads were used to decrease the noise interference and movement of the head, respectively. A high-resolution three-dimensional T1-weighted imaging (3D-T1WI), DTI was acquired with the following parameters: (1) the parameters of 3DT1 sequence using an axial fast spoiled gradient-recalled sequence were as follows: repetition time (TR)/echo time (TE) = 6.008 ms/1.98 ms, slice thickness = 1 mm, matrix size = 256 × 256, and field of view = 256 × 256 mm² (2). The DTI sequence using a spin-echo imaging sequence included the following parameters: field of view = 256 × 256 mm², TR/TE = 8,500 ms/minimum, matrix size = 128 × 128, slice thickness = 2 mm, and 78 slices with no gap. Two diffusion-weighted sequences were acquired using gradient values b = 0 s/mm² and b = 1,000 s/mm² with the diffusion-sensitizing gradients applied along 64 non-linear directions.