Vidas d dimer exclusion

Manufactured by bioMérieux

Sourced in France

The VIDAS D-dimer Exclusion is a lab equipment product from bioMérieux. It is an automated quantitative test used to aid in the exclusion of deep venous thrombosis (DVT) and pulmonary embolism (PE).

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Lab products found in correlation

Hemosil d dimer hs, by Werfen (1 mentions) Sta liatest d dimer, by Diagnostica Stago (1 mentions) Cobas h232, by Roche (1 mentions) Hemosil d dimer hs 500, by Werfen (1 mentions) Innovance d dimer, by Siemens (1 mentions)

3 protocols using vidas d dimer exclusion

Cardiac Biomarkers and D-Dimer in APE

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Blood samples were collected from patients within the first 24 h after admission. Serum cardiac troponin I (cTnI) and high-sensitivity cardiac troponin T (cTnT-hs) were measured quantitatively using an automated sandwich electrochemiluminescence immunoassay (Roche Diagnostics GmbH, Mannheim, Germany). Levels above 0.014 ng/mL for cTnT-hs and 0.1 ng/mL for cTnI were considered elevated. Plasma D-dimer concentrations were measured using an automated enzyme-linked fluorescent assay VIDAS D-Dimer Exclusion (bioMerieux, Marcy-l’Étoile, France) with a threshold of 500 ng/mL in diagnosing APE.

Karolak B., Ciurzyński M., Skowrońska M., Kurnicka K., Pływaczewska M., Furdyna A., Perzanowska-Brzeszkiewicz K., Lichodziejewska B., Pacho S., Machowski M., Bienias P., Wiśniewska M., Gołębiowski M, & Pruszczyk P. (2023). Plasma Troponins Identify Patients with Very Low-Risk Acute Pulmonary Embolism. Journal of Clinical Medicine, 12(4), 1276.

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D-dimer Assay Cutoffs for VTE Risk

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D-dimer concentrations were assessed with the quantitative assay routinely used in each participating center, provided it was one of the following: Cobas h232 (Roche Diagnostics; Switzerland), HemosIL D-dimer HS 500 (Instrumentation Laboratory; Milan, Italy), HemosIL D-dimer HS (Instrumentation Laboratory), HemosIL D-dimer (Instrumentation Laboratory), Innovance D-DIMER (Siemens; Deerfield, IL), Sclavo Auto D-dimer (Dasit; Milan, Italy), STA Liatest D-dimer (Diagnostica Stago; Asnieres-sur-Seine, France), and VIDAS D-dimer Exclusion (bioMerieux; Lyon, France). For the assays expressing results as fibrinogen equivalent units, the cutoffs were 350 ng/mL and 500 ng/mL for males and females, respectively; the cutoffs for assays expressing the results as D-dimer units were 175 ng/mL and 250 ng/mL for males and females, respectively. These cutoffs were selected by the study team after a critical evaluation of the Dulcis study results,⁷ (link) taking into account that (1) patients aged ≥75 years were excluded from the present study (and therefore, there was no need for different cutoff levels according to the age) and (2) male patients are unanimously recognized at higher risk of recurrence than females (for this reason the decided cutoff level was lower for males than females).

Palareti G., Poli D., Ageno W., Legnani C., Antonucci E., Bucherini E., Testa S., Paoletti O., Chistolini A., Serrao A., Martinelli I., Bucciarelli P., Falanga A., Tosetto A., Sarti L., Mastroiacovo D., Cosmi B., Visonà A., Santoro R.C., Zanatta N., Grandone E., Bertù L., Pengo V., Caiano L, & Prandoni P. (2022). D-dimer and reduced-dose apixaban for extended treatment after unprovoked venous thromboembolism: the Apidulcis study. Blood Advances, 6(23), 6005-6015.

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COVID-19 Diagnostic Protocol with Biomarkers

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COVID-19 was diagnosed when acute respiratory symptoms or an exacerbation of chronic respiratory symptoms were present and one of the following occurred: SARS-CoV-2 target genes were detected using a reverse-transcriptase polymerase chain reaction (RT-PCR) assay (CovGenX) from biological material, collected using nasopharyngeal swabs or with a positive immunochromatographic lateral flow test, detecting the target nucleocapsid protein of SARS-CoV-2 from nasopharyngeal swabs (Abbott, Chicago, IL, USA).
Plasma concentrations of troponin T were measured as part of a standard diagnostic protocol using a high-sensitivity automated sandwich electrochemiluminescence immunoassay (Roche Diagnostics GmbH, Mannheim, Germany). Values above 0.014 ng/mL were considered elevated.
D-dimer concentrations were quantitatively measured, on the day of admission, as part of a standard diagnostic protocol using an automated enzyme-linked fluorescent assay (VIDAS D-dimer Exclusion, bioMerieux, Marcy-l’Étoile France) or using a turbidimetric immunoassay (HemosIL, Werfen, Spain); depending on patient location, both had a reference range of values up to 500 ng/mL.

Machowski M., Polańska A., Gałecka-Nowak M., Mamzer A., Skowrońska M., Perzanowska-Brzeszkiewicz K., Zając B., Ou-Pokrzewińska A., Pruszczyk P, & Kasprzak J.D. (2022). Age-Adjusted D-Dimer Levels May Improve Diagnostic Assessment for Pulmonary Embolism in COVID-19 Patients. Journal of Clinical Medicine, 11(12), 3298.

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