Nelarabine

Manufactured by Merck Group

Sourced in United States

Nelarabine is a laboratory product developed by Merck Group. It functions as a nucleoside analog, providing a tool for researchers in various scientific fields.

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Lab products found in correlation

2 protocols using nelarabine

Synergistic Potential of Compounds

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BV was obtained from Takeda Pharmaceutical Company Limited (Tokyo, Japan). IgG was purchased from GeneTex (Irvine, CA, USA). Fourteen candidate drugs were assessed as potential synergistic partners of BV. Belinostat, romidepsin, and darinaparsin were purchased from Toronto Research Chemicals Inc. (North York, ON, Canada). Pralatrexate, chidamide, deoxycoformycin, dexamethasone, lenalidomide, gemcitabine, doxorubicin, etoposide, and MK2206 were purchased from MedChemExpress (Monmouth Junction, NJ, USA). Selinexor was purchased from Ark Pharm (Arlington Heights, IL, USA). Nelarabine was purchased from Sigma-Aldrich (St Louis, MO, USA).

Tonozuka Y., Tanaka H., Nomura K., Sakaguchi K., Soeda J, & Kakimoto Y. (2023). The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis. Cancer Chemotherapy and Pharmacology, 93(2), 137-149.

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Chemotherapy-Induced T-ALL Cell Apoptosis

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T-ALL cells (10,000 or 40,000 per well) were seeded in 96-well plates and incubated with chemotherapeutic agents at the doses indicated below for 48 h. Chemotherapy doses were as follows unless otherwise indicated: asparaginase, 10 international units/ml (Sigma-Aldrich); dexamethasone, 10 µM (Sigma-Aldrich); vincristine, 1 µM (Selleckchem); doxorubicin, 1 µM (Sigma-Aldrich); etoposide, 10 µM (Sigma-Aldrich); cytarabine, 10 µM (Selleckchem); nelarabine, 10 µM (Sigma-Aldrich); 6-mercaptopurine, 10 µM (Abcam); and methotrexate, 10 µM (Selleckchem). Annexin V and propidium iodide staining were assessed using the Apoptosis Detection kit II (BD Biosciences), and caspase 3/7 activity was assessed using the Caspase Glo 3/7 Assay (Promega) according to the manufacturer’s instructions.

Ariës I.M., Bodaar K., Karim S.A., Chonghaile T.N., Hinze L., Burns M.A., Pfirrmann M., Degar J., Landrigan J.T., Balbach S., Peirs S., Menten B., Isenhart R., Stevenson K.E., Neuberg D.S., Devidas M., Loh M.L., Hunger S.P., Teachey D.T., Rabin K.R., Winter S.S., Dunsmore K.P., Wood B.L., Silverman L.B., Sallan S.E., Van Vlierberghe P., Orkin S.H., Knoechel B., Letai A.G, & Gutierrez A. (2018). PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia. The Journal of Experimental Medicine, 215(12), 3094-3114.

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