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3t connectome scanner

Manufactured by Siemens
Sourced in Germany

The 3T Connectome Scanner is a powerful magnetic resonance imaging (MRI) system designed for advanced brain imaging research. It operates at a magnetic field strength of 3 Tesla, providing high-resolution images of the brain's structural and functional connectivity. The scanner is capable of acquiring data for diffusion-weighted imaging, which enables the study of white matter tracts and the brain's neural networks.

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5 protocols using 3t connectome scanner

1

Human Connectome Project Diffusion MRI

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HCP3T, 90 gradient directions, 1.25 mm isotropic resolution. Data of four subjects, part of the Human Connectome Project54 , acquired using a Siemens 3 T “Connectome” scanner were used. Measurements from the 2,000 s/mm2 shell were extracted from the original dataset and used for all analyses. Processing methods are described in22 (link).
HCP7T, 60 gradient directions, 1.05 mm isotropic resolution. Five subjects part of the Human Connectome 7-Tesla (7 T) dataset were used. Data were collected a Siemens 7 T scanner55 . Measurements from the 2,000 s/mm2 shell were extracted from the original data and were used for further analyses.
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2

Diffusion MRI Protocol with High b-Values

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We also tested our method using the MGH HCP data set acquired on the Siemens 3T Connectome scanner with maximum gradient strength of 300 mT/m. The spatial resolution of this data set was 1.5 × 1.5 × 1.5 mm3. The experimental parameters were TR/TE = 8800/57 ms, δ = 12.9 ms and Δ = 21.8 ms. The data set consisted of four b-values with b = 1000, 3000, 5000 and 10000 s/mm2. The number of gradient directions at each b-shell were 64, 64, 128 and 256, respectively. More detailed information about data acquisition and pre-processing steps can be found in (Setsompop et al., 2013 (link)).
The maximum q-value that can be reached in this data set is about 0.7559 radm, which allows for probing short-range disturbances as well. In order to incorporate short-range disturbances, we extend the model (34) to the three-dimensional case as follows:
s(q,u)=uTM2u+q2uTM4u+(1uTM2uq2uTM4u)eq2(Δδ/3)uTDu, where M2 and D are both 3 × 3 positive semidefinite tensors as before. Similar to the previous experiment, we assume that Û2, Û4 and D0 all have the same set of eigenvectors. From M2 and M4, we define Û2 := M2D and Û4 = M4D. The eigenvalues for the three tensors are denoted by {û2,‖, û2,⊥, û2,⊥}, {û4,‖, û4,⊥, û2,⊥} and {d, d, d}, respectively.
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3

Diffusion Imaging on Customized 3T Scanner

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Diffusion data for the HCP was acquired on a customized Siemens 3 T Connectome Scanner using a standard 32-channel Siemens receiver head coil and a “body” transmission coil designed by Siemens. The customized hardware includes gradient coils and gradient power amplifiers that increase the maximum gradient strength from 40 mT/m to 100 mT/m, which specifically provides benefits for the quality of the diffusion imaging [58 (link)]. The diffusion sequence consisted of a Spin-echo EPI (TR 5520 ms, TE 89,5 ms, flip angle 78 deg, refocusing flip angle 160 deg, FOV 210 × 180 (RO × PE), matrix 168 × 144 (RO × PE), slice thickness 1.255 mm, 111 slices, 1.25 mm isotropic voxels, multiband factor 3, echo spacing 0.78 ms, BW 1488 Hz/Px, phase partial fourier 6/8), with the full diffusion session including 6 runs (approximately 9 minutes and 50 seconds each) of three different gradient tables acquired in both right-left and left-right phase encoding directions. Each diffusion gradient table included 90 diffusion weighted directions with 6 interspersed b=0 acquisitions. The three diffusion gradients consisted of b=1000, 2000, and 3000s/mm2 shells with approximately equal acquisitions for each run [57 (link)], [58 (link)].
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4

Healthy Subjects MRI Acquisition

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One hundred unrelated healthy subjects (age range 22–36, 54 females) provided by the HCP database were used. As validation sample, twenty additional subjects (age range 23–35, 8 females) were randomly selected from the HCP database. All subjects were scanned on a customized 3T Connectome Scanner adapted from a Siemens Skyra (Siemens AG, Erlangen, Germany) with a 32-channel head coil and completed behavioral assessment at Washington University34 (link),35 (link). In addition to basic demographic information (age in years, sex), measures for obesity and cardiovascular fitness were selected from the available data. The HCP protocol was approved by the Institutional Review Board at Washington University in St. Louis and data acquisition was in accordance with the declaration of Helsinki36 (link). All participants provided written informed consent for the project.
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5

Healthy Adult Brain Imaging Protocol

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For this we used the resting state and structural data from 1113 young healthy adults (age 22 to 37 years) obtained from the publicly available WU-Minn HCP 1200 Subjects Data Release from the Human connectome Project (Van Essen et al., 2012; https://db.humanconnectome.org). Scans were acquired with a using a customized 3T Connectome Scanner adapted from a Siemens Skyra (Siemens AG, Erlanger, Germany).
For each participant, an anatomical image was recorded using a T1-weighted 3D MPRAGE
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