Indocyanine green icg

Manufactured by Merck Group

Sourced in United States, China

Indocyanine green (ICG) is a water-soluble, near-infrared fluorescent dye used in various medical and research applications. It is a diagnostic agent that can be used to visualize blood flow and tissue perfusion. ICG absorbs and emits light in the near-infrared spectrum, making it suitable for non-invasive imaging techniques.

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Lab products found in correlation

Fetal bovine serum (fbs), by Thermo Fisher Scientific (5 mentions) Streptomycin, by Thermo Fisher Scientific (4 mentions) Trypsin edta, by Thermo Fisher Scientific (4 mentions) Ethanol, by Merck Group (3 mentions) Penicillin, by Thermo Fisher Scientific (3 mentions) Soybean lecithin, by Avanti Polar Lipids (2 mentions) Cell counting kit 8 cck 8, by Dojindo Laboratories (2 mentions) Phosphate buffered saline (pbs), by Thermo Fisher Scientific (2 mentions) Dichloromethane, by Merck Group (2 mentions) Hydrochloric acid (hcl), by Sinopharm (2 mentions) Sodium hydroxide (naoh), by Merck Group (2 mentions) Acetonitrile, by Merck Group (2 mentions) Polyvinyl alcohol (pva), by Merck Group (2 mentions) Rpmi 1640 medium, by Thermo Fisher Scientific (2 mentions) Singlet oxygen sensor green (sosg), by Thermo Fisher Scientific (2 mentions) Dspe peg cooh, by Avanti Polar Lipids (1 mentions) Chloral hydrate, by Merck Group (1 mentions) Tumor necrosis factor alpha tnf α, by Merck Group (1 mentions) Irgd peptide crgdkgpdc, by GL Biochem (1 mentions) Human umbilical vein endothelial cells huvecs, by American Type Culture Collection (1 mentions)

37 protocols using indocyanine green icg

Dual-targeted Theranostic Nanoparticles

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Soybean lecithin and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-maleimide (polyethylene glycol 2000) carboxylic acid (DSPE-PEG-COOH) were purchased from Avanti Polar Lipids (Alabama, USA). Poly (lactide-co-glycolide) (PLGA), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), N-hydroxysuccinimide (NHS), methotrexate (MTX) and indocyanine green (ICG) were obtained from Sigma-Aldrich (Missouri, USA). Unless stated otherwise, all other materials used were purchased from Sigma-Aldrich (Missouri, USA). Placental CSA-binding peptide (plCSA-BP, EDVKDINFDTKEKFLAGCLIVSFHEGKC) and N-terminal α-amino-biotinylated plCSA-BP (biotin-plCSA-BP) were purchased from ChinaPeptides Co.,Ltd. (Shanghai, China). The scrambled peptide (SCR, EVDNDKKLGLVFEKDKIFTEFACISHCG) and N-terminal α-amino-biotinylated SCR (biotin-SCR) were synthesized at Shanghai GL Biochem Co., Ltd. (Shanghai, China).

Zhang B., Tan L., Yu Y., Wang B., Chen Z., Han J., Li M., Chen J., Xiao T., Ambati B.K., Cai L., Yang Q., Nayak N.R., Zhang J, & Fan X. (2018). Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice. Theranostics, 8(10), 2765-2781.

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Multifunctional Nanoparticles for Targeted Cancer Therapy

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Soybean lecithin and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy (polyethylene glycol)-2000] (DSPE-PEG-COOH) were purchased from Avanti Polar Lipids (Alabaster, AL). Poly(dl-lactic-co-glycolic acid) (50:50) (PLGA), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS), doxorubicin (DOX) and indocyanine green (ICG) were purchased from Sigma-Aldrich (St. Louis, MO). CSA-binding peptide (EDVKDINFDTKEKFLAGCLIVSFHEGKC) (Resende et al., 2008 (link)) and the scrambled peptide (SCR, EVDNDKKLGLVFEKDKIFTEFACISHCG) were synthesized by ChinaPeptides Co., Ltd. (Shanghai, China) and Shanghai GL Biochem Co. Ltd. (Shanghai, China), respectively. Unless stated otherwise, all other materials used were obtained from Sigma-Aldrich (St. Louis, MO).

Zhang B., Cheng G., Zheng M., Han J., Wang B., Li M., Chen J., Xiao T., Zhang J., Cai L., Li S, & Fan X. (2018). Targeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment. Drug Delivery, 25(1), 461-471.

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Coronavirus Infected Mouse Model for Targeting Efficacy

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To establish coronavirus infected mouse mode, 6-week-old BALB/c female mice (purchased from Guangdong Medical Experimental Animal Center) were anesthetized with 4% chloral hydrate intraperitoneally (Sigma), and then inoculated intranasal with 15 μL of MHV (2.5 × 10⁵ PFU). Two days after intranasal inoculation, infected mice were sacrificed, and the main organs were collected for pathologic analysis.
To evaluate targeting efficacy of PLGA@M, indocyanine Green (ICG, Sigma) loaded PLGA NPs, ICG loaded PLGA@M and free ICG (200 μL, 100 ug/mL) were injected intravenously into the coronavirus infected mice. After 12 h, treated mice were sacrificed, lungs and livers were collected and imaged with the IVIS LuminaIII Series system (PerkinElmer).

Tan Q., He L., Meng X., Wang W., Pan H., Yin W., Zhu T., Huang X, & Shan H. (2021). Macrophage biomimetic nanocarriers for anti-inflammation and targeted antiviral treatment in COVID-19. Journal of Nanobiotechnology, 19, 173.

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Targeted Nanoparticle Delivery for Arthritis

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1,2-Distearoyl-sn-glycero-3-pho-sphoethanolamine-N-[met-hoxy(poly-ethyleneglycol)-2000] (DSPE-PEG₂₀₀₀), 1,2-distearoyl-sn-glycero-3phosphoethanolamine-N-[maleimide(polyethylenegl-ycol)-2000] (DSPE-PEG₂₀₀₀-Mal), dipalmitoylphosphatidylcholine (DPPC), and cholesterol were purchased from Avanti Polar Lipids Inc (Alabaster, AL, USA). iRGD peptide (CRGDKGPDC) was synthesized by GL biochem Ltd (Shanghai, China). Indocyanine green (ICG) and tumor necrosis factor alpha (TNF-α) were purchased from Sigma-Aldrich Co. (St Louis, MO, USA). Bovine type II collagen, complete Freund’s adjuvant, and incomplete Freund’s adjuvant were purchased from Condrex, Redmond, WA, USA. Human umbilical vein endothelial cells (HUVECs) were purchased from the American Type Culture Collection (Manassas, VA, USA). Male DAB/1J mice were obtained from Vitalriver Experimental Animal Technology Ltd (Beijing, China). Animals received care in accordance with the Guidance Suggestions for the Care and Use of Laboratory Animals.

Wu H., Wu H., He Y., Gan Z., Xu Z., Zhou M., Liu S, & Liu H. (2018). Synovitis in mice with inflammatory arthritis monitored with quantitative analysis of dynamic contrast-enhanced NIR fluorescence imaging using iRGD-targeted liposomes as fluorescence probes. International Journal of Nanomedicine, 13, 1841-1850.

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Fluorescent Tracers for Biological Assays

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Lysine fixable dextrans Texas Red 2000kDa MW and Texas Red 70kDa MW were purchased from Molecular Probes (Invitrogen, Eugene, OR). Indocyanine green (ICG) and all other analytical grade chemicals were purchased from Sigma-Aldrich (St. Louis, MO).

Bohn K.A., Adkins C.E., Mittapalli R.K., Terrell-Hall T.B., Mohammad A.S., Shah N., Dolan E.L., Nounou M.I, & Lockman P.R. (2016). Semi-automated Rapid Quantification of Brain Vessel Density Utilizing Fluorescent Microscopy. Journal of neuroscience methods, 270, 124-131.

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Multifunctional Nanoparticle Synthesis

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Triton X-100, hexanol, cyclohexane, toluene, fullerene (C60), tetraethyl orthosilicate (TEOS), (3-aminopropyl) trimethoxysilane (APTMS), doxorubicin hydrochloride (DOX) and indocyanine green (ICG) were purchased from Sigma (St. Louis, MO, USA). Hyaluronan (HA) was purchased from Lifecore Biomedical (Chaska, MN, USA). Fetal bovine serum (FBS), penicillin, and streptomycin were purchased from Invitrogen (Carlsbad, CA, USA). The DMEM, EMEM and DMEM/F-12K cell culture media was purchased from ATCC (Manassas, VA, USA). The cell counting kit-8 (CCK-8) was purchased from Dojindo Molecular Technologies (Rockville, MD, USA). All other chemicals were purchased from Sigma unless specifically mentioned otherwise.

Wang H., Agarwal P., Zhao S., Yu J., Lu X, & He X. (2016). Combined Cancer Therapy with Hyaluronan-Decorated Fullerene-Silica Multifunctional Nanoparticles to Target Cancer Stem-Like Cells. Biomaterials, 97, 62-73.

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Biodegradable Nanoparticles for Targeted Imaging

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All chemicals in this study were used as received: poly(lactide-co-glycolide) (PLGA, Mw 54,000–69,000, PolySciTech), poly(lactide-co-glycolide)-b-poly(ethylene glycol) (PLGA-PEG, PolySciTech), poly(lactide-co-glycolide)-b-poly(ethylene glycol)-maleimide (PLGA-PEG-Mal, PolySciTech), poly(vinyl alcohol) (PVA, average Mw 13,000–23,000, Sigma-Aldrich), dichloromethane (Sigma-Aldrich), indocyanine green (ICG, Sigma-Aldrich) Growth factor reduced Matrigel (Corning), Phosphate-buffered saline (PBS, Thermo Fisher Scientific), Presto Blue (Invitrogen), anti-GRPR antibody (AbCam, ∼48 kDa). Selenocystamine (Sigma-Aldrich), Dithiothreitol (Sigma-Aldrich).

Zhao S., Lee L., Zhao Y., Liang N.C, & Chen Y.S. (2023). Photoacoustic signal enhancement in dual-contrast gastrin-releasing peptide receptor-targeted nanobubbles. Frontiers in Bioengineering and Biotechnology, 11, 1102651.

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Potassium Permanganate-Mediated PAH Therapy

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Potassium permanganate, polycyclic-aromatic hydrocarbons (PAH, 15000) were purchased from Sinopharm Chemical Reagent Co., Ltd. (Shanghai, China). Indocyanine green (ICG) was obtained from Sigma-Aldrich (St. Louis, USA). All cell culture products were obtained by GIBCO (Grand Island, NY, USA). Calcein- AM/PI double dyeing kit, annexin V-FITC/PI apoptosis detection kits were supplied by Yeasen Co. (Shanghai, China). Deionized (DI) water in 18.2 MΩ resistivity was applied in all aqueous solutions preparation.
PD-L1 siRNA labelled with FAM (siPD-L1) were purchased from Shanghai Gene Pharma Co.Ltd. (Shanghai, China), the sequences as follows: siPD-L1, sense: 5'-GGC GUU UAC UGC UGC AUA ATT-3'.

Liu Y., Pan Y., Cao W., Xia F., Liu B., Niu J., Alfranca G., Sun X., Ma L., de la Fuente J.M., Song J., Ni J, & Cui D. (2019). A tumor microenvironment responsive biodegradable CaCO3/MnO2- based nanoplatform for the enhanced photodynamic therapy and improved PD-L1 immunotherapy. Theranostics, 9(23), 6867-6884.

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Formulation and Characterization of Lipid Nanoparticles

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CaCl₂ (96%), MnCl₂ 4H₂O, NH₄HCO₃ (99%), indocyanine green (ICG), cholesterol, dichloromethane (DCM), and ethanol were purchased from Sigma-Aldrich (USA). 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)₂₀₀₀] (DSPE-PEG_2K), DOPA, and DOPC were purchased from Avanti Polar Lipids (USA). Unless otherwise mentioned, all chemicals were used as received and without further purification.

Wang M., Zhou B., Wang L., Zhou F., Smith N., Saunders D., Towner R.A., Song J., Qu J, & Chen W.R. (2020). Biodegradable pH-responsive amorphous calcium carbonate nanoparticle as an immunoadjuvant for multimodal imaging and enhanced photoimmunotherapy. Journal of materials chemistry. B, 8(36), 8261-8270.

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Multimodal Cell Imaging and Cytotoxicity Assessment

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Ethanol, stannum powder (10 μm, 99% trace metals basis), CCK-8 kit, indocyanine green (ICG), 2-(4-amidinophenyl)-6-indolecarbamidine dihydrochloride (DAPI), calcein-AM, and propidium iodide (PI) were purchased from Sigma-Aldrich. Phosphate-buffered saline (PBS, pH 7.4, 10 mM), penicillin–streptomycin, trypsin–EDTA, fetal bovine serum (FBS), and cell culture medium were brought from Gibco Life Technologies (AG, Switzerland). JC-1 Kit was purchased from Cayman Chemical. 1,2-Distearoyl-sn-glycero-3-phosphoEthanolamine-N-[methoxy (poly-ethylene glycol)] (DSPE-PEG, MW 5000 Da, PG1-DS-5 k) was obtained from Nanocs, Inc. The other reagents were analytically pure and no need further purification for use. Ultrapure water (18.2 MΩ cm) was applied in all experiments.

Ouyang J., Zhang L., Li L., Chen W., Tang Z., Ji X., Feng C., Tao N., Kong N., Chen T., Liu Y.N, & Tao W. (2021). Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics. Nano-Micro Letters, 13, 90.

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