Water-soluble porphyrins: disodium salt of 3,8-di (1-methoxyethyl) deuteroporphyrin IX (dimegin, DMG, synthesized by G.V. Ponomarev at the Institute of Biological and Medicinal Chemistry, Moscow, Russia) and three sodium salt of chlorin e6 (Ce6, Frontier scientific Inc., Logan, UT, USA), and hydrophobic porphyrins: 5,10,15,20-tetraphenylporphyrin (TPP, synthesized by G.V. Ponomarev at the Institute of Biological and Medicinal Chemistry, Moscow, Russia) and fluorinated tetraphenyl porphyrin-5,10,15,20-tetrakis (pentafluorophenyl) porphyrin (TPPF20, (Sigma-Aldrich, Saint Louis, MO, USA)) were used as photosensitizers. The structures of the photosensitizers are shown in Figure 1 .
Poly-N-vinylpyrrolidone (PVP, 4 × 104 M, Sigma-Aldrich, Saint Louis, MO, USA) and a ternary block copolymer of ethylene and propylene oxide, Pluronic F127 (F127, 12.6 × 10−3 M, BASF, Ludwigshafen, Germany), are well-studied and widely used in medicine. Chitosan (CT100) was purchased from Sigma-Aldrich (#448869) with a Mw = (50–190) × 103 Da and a deacetylation degree DA = 75–85% and was used without additional purification (Sigma-Aldrich, Saint Louis, MO, USA). Chitosan was used as a biologically active polysaccharide, while tryptophan (Trp, Sigma-Aldrich, Saint Louis, MO, USA) was utilized as a substrate. The structures of polymers are shown inFigure 2 .
Poly-N-vinylpyrrolidone (PVP, 4 × 104 M, Sigma-Aldrich, Saint Louis, MO, USA) and a ternary block copolymer of ethylene and propylene oxide, Pluronic F127 (F127, 12.6 × 10−3 M, BASF, Ludwigshafen, Germany), are well-studied and widely used in medicine. Chitosan (CT100) was purchased from Sigma-Aldrich (#448869) with a Mw = (50–190) × 103 Da and a deacetylation degree DA = 75–85% and was used without additional purification (Sigma-Aldrich, Saint Louis, MO, USA). Chitosan was used as a biologically active polysaccharide, while tryptophan (Trp, Sigma-Aldrich, Saint Louis, MO, USA) was utilized as a substrate. The structures of polymers are shown in