Trichostatin a

Manufactured by Cell Signaling Technology

Trichostatin A is a histone deacetylase (HDAC) inhibitor. It functions by inhibiting the enzymatic activity of HDAC, which plays a role in regulating gene expression.

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Lab products found in correlation

Rabbit anti ha tag c29f4, by Cell Signaling Technology (1 mentions) Nicotinamide n3376, by Merck Group (1 mentions) Rabbit anti myc tag 71d10, by Cell Signaling Technology (1 mentions) Rabbit anti sirt1 c14h4, by Cell Signaling Technology (1 mentions) Human serum albumin (hsa), by Merck Group (1 mentions) Mc1568, by Merck Group (1 mentions)

Spelling variants of this product

Trichostatin A (TSA) (9 citations)

2 protocols using trichostatin a

Antibodies and Small Molecules for Protein Analysis

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Rabbit anti-TULP1 (ab97281) and rabbit anti-TULP3 antibody (ab155317) were obtained from Abcam. HDAC Inhibitor XXIV (OSU-HDAC-44) was obtained from Calbiochem. Cycloheximide (2112S), MG-132 (2194S), rabbit antiacetylated lysine (#9441S), rabbit anti-beta actin (13E5, #4970S), rabbit anti-CUL3 (#2759S), rabbit anti-HA tag (C29F4, #3724T), mouse anti-HDAC1 (10E2, #5356S), antimouse IgG, HRP linked antibody (7076S), rabbit anti-Myc tag (71D10, #2278S), rabbit anti-P300 (D1M7C, #70088S), rabbit anti-Rad18 (D2B8, #9040S), rabbit anti-SIRT1 (C14H4, #2496S), anti-rabbit IgG, HRP linked antibody (7074S), rabbit antiubiquitin (#3933S), Trichostatin A (9950S) were obtained from Cell Signaling Technology, Inc. Rabbit anti-PP6R3 (16944-1-AP) was obtained from Proteintech. Anacardic Acid (A7236), Anti-FLAG (M2, #F1804), C646 (SML0002), EX-527 (E7034), MC1568 (M1824), mouse antiacetyl lysine (4G12, 05-515), mouse anti-TULP2 (2B5, WH0007288M3), MS-275 (EPS002), and nicotinamide (N3376) were obtained from Sigma Aldrich.

Kerek E.M., Yoon K.H., Luo S.Y., Chen J., Valencia R., Julien O., Waskiewicz A.J, & Hubbard B.P. (2020). A conserved acetylation switch enables pharmacological control of tubby-like protein stability. The Journal of Biological Chemistry, 296, 100073.

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Immune Stimulant Protocol Optimization

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α-Galactosylceramide, was purchased from Enzo Life Sciences (New York City, NY, USA) and used at a final concentration of 100 ng/mL. Human Serum Albumin was purchased from Sigma-Aldrich and used at 10μM final concentration. Trichostatin A was purchased from Cell Signaling Technology and reconstituted in ethanol. MC1568 (Sigma-Aldrich) was reconstituted in DMSO. Panobinostat/LBH589 (Biovision (Milpitas, CA, USA)) was reconstituted in DMSO.

Tiper I.V, & Webb T.J. (2016). Histone deacetylase inhibitors enhance CD1d-dependent NKT cell responses to lymphoma. Cancer immunology, immunotherapy : CII, 65(11), 1411-1421.

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