Ly379196

Manufactured by Eli Lilly

Sourced in United Kingdom

LY379196 is a laboratory equipment product manufactured by Eli Lilly. It is designed for use in scientific research and analysis. The core function of this product is to provide a reliable and consistent means of performing specific laboratory tasks. Further details about the intended use or application of this product are not available.

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Lab products found in correlation

4 aminopyridine, by Merck Group (1 mentions) Quinpirole, by Merck Group (1 mentions) Sulpiride, by Merck Group (1 mentions) Complete mini protease inhibitor, by Roche (1 mentions) Butaclamol, by Merck Group (1 mentions) 3h sulpiride, by PerkinElmer (1 mentions) G 6976, by Bio-Techne (1 mentions)

2 protocols using ly379196

Pharmacological Reagents for Neuroscience

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LY379196 was a generous gift from Eli Lilly (Indianapolis, Indiana). Enzastaurin was purchased from LC Labs (Woburn, MA). [³H]-sulpiride was from PerkinElmer (Waltham, MA). Complete Mini protease inhibitor was purchased from Roche Diagnostics (Indianapolis, IN). All other chemicals, including 4-aminopyridine, quinpirole, sulpiride, and butaclamol, were purchased from Sigma Aldrich (St. Louis, MO).

Luderman K.D., Chen R., Ferris M.J., Jones S.R, & Gnegy M.E. (2015). Protein Kinase C Beta Regulates the D2-Like Dopamine Autoreceptor. Neuropharmacology, 89, 335-341.

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Tat-linked PKC Inhibitor Peptides in Cardiomyocytes

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Tat-linked PKC inhibitor peptides were used at a concentration of 100 nM as described previously (14 (link), 25 (link), 31 (link)). Cardiomyocytes were preincubated with PKCα and β-specific Tat-linked inhibitor peptides for 15 min prior to the protocol outlined in each figure. PKCα and β were also pharmacologically inhibited in isolated cardiomyocytes using Gö6976 (300 nM: Tocris, Bristol, United Kingdom) and LY379196 (300 nM; a kind gift from Eli Lilly, IND, United States) which were perfused with the NT solutions as indicated in the figures. Equivalent concentrations of vehicle (DMSO) had no effect on cardiomyocyte function.

Brennan S., Esposito S., Abdelaziz M.I., Martin C.A., Makwana S., Sims M.W., Squire I.B., Sharma P., Chadwick A.E, & Rainbow R.D. (2022). Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection. Frontiers in Cardiovascular Medicine, 9, 997013.

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