Decabromodiphenyl ether

Manufactured by Merck Group

Sourced in France

Decabromodiphenyl ether is a chemical compound used in the production of certain types of laboratory equipment. It serves as a flame retardant additive to enhance the fire resistance of materials. The core function of this product is to improve the safety and durability of the equipment.

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Lab products found in correlation

2 protocols using decabromodiphenyl ether

Preparation of Ecotoxicological Chemical Mixture

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The following chemicals were purchased from Sigma-Aldrich (Saint-Quentin Fallavier, France): bisphenol-A (BPA purity >99%), triclosan (TCS >97%), benzophenone-3 (BP3_98%), decabromodiphenyl ether (BDE-209 98%), sodium perchlorate (>98%), 4-4′-dichlorodiphenyldichloroethylen (4,4′-DDE 99%), hexachlorobenzene (HCB 99.9%), dibutylphtalate (DBP 99%), diethylhexylphtalate (DEHP 99%), PCB-153, 2-Naphtol (99%), perfluorooctanesulfonic acid (PFOS >98%), perfluorooctanoic acid (PFOA >98%), methyl mercury chloride (>99.9%), lead chloride (98%), dimethyl sulfoxide (DMSO), acetone, 3,3′,5,5′tetraiodo-L-thyronine T₄ >98%) and triiodothyronine (T₃ 99%). NH-3, a thyroid hormone antagonist18 (link) was synthesized by AGV Discovery (France), absence of contamination by benzofurane was verified56 (link). All chemicals were dissolved at 10⁻¹ M in DMSO, with the exception of HCB (10⁻¹ M in acetone) and BDE 209 (10⁻²M in DMSO). These solutions were aliquoted and stored at −20 °C until use. T₃ was prepared in 30% NaOH, 70% milliQ Water at 10⁻²M concentration, aliquoted and stored at −20 °C until use. The chemical mixture was prepared at 10⁵-fold concentration by mixing appropriate volumes of stocks as described in Supplementary Table 1, aliquoted and stored at −20 °C.

Fini J.B., Mughal B.B., Le Mével S., Leemans M., Lettmann M., Spirhanzlova P., Affaticati P., Jenett A, & Demeneix B.A. (2017). Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos. Scientific Reports, 7, 43786.

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Developmental Decabromodiphenyl Ether Exposure in Mice

Cited 1 time

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Adult male and female C57BL/6 J inbred mice (The Jackson Laboratory, Bar Harbor, ME) were housed in vivarium quarters at the State University of New York at Geneseo, fed standard pellet chow (LabDiet 5001, Brentwood, MO) ad libitum, and were maintained on a reversed 12-hr light:12-hr dark cycle in a room with an ambient temperature of 20 ± 2 °C and 40–60% humidity.
During the breeding period, females were examined every morning for the presence of a sperm plug. The day of birth was considered postnatal day (PND) 0 and litters were culled to 3 male and 3 female pups on PND1. Litters with fewer than 6 pups or a skewed sex distribution were not used. From PND1–21, each pup was administered a single oral dose per day of 0 or 20 mg decaBDE/kg bodyweight (product 194425, 98% 2,2′,3,3′,4,4′,5,5′,6,6′-decabromodiphenyl ether, Sigma-Aldrich) in an artificial breast milk as described in Markowski et al. [22 (link)]. All animal procedures complied with approved institutional animal care protocols and were in accordance with NIH guidelines [18 ]. Animal care and welfare were supervised by a veterinarian.

Edwards C.M., Small D., Bell T., David-Drori J., Hansen C., Morris-Schaffer K., Canale C., Ng J, & Markowski V.P. (2020). Early postnatal decabromodiphenyl ether exposure reduces thyroid hormone and astrocyte density in the juvenile mouse dentate gyrus. Physiology & behavior, 216, 112798.

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