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Win55 212

Manufactured by Bio-Techne
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WIN55,212 is a synthetic cannabinoid compound that acts as an agonist for the CB1 and CB2 cannabinoid receptors. It is commonly used in research applications to study the effects of cannabinoid receptor activation.

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Lab products found in correlation

L name, by Bio-Techne (1 mentions) Zd7288, by Bio-Techne (1 mentions) Anisomycin, by Bio-Techne (1 mentions) Gallein, by Bio-Techne (1 mentions) Jzl184, by Bio-Techne (1 mentions) Sp600125, by Bio-Techne (1 mentions) Am251, by Bio-Techne (1 mentions) Cptio, by Cayman Chemical (1 mentions) Urb597, by Bio-Techne (1 mentions) Sb203580, by Bio-Techne (1 mentions) Complete freund adjuvant (cfa), by Merck Group (1 mentions) Streptozotocin (stz), by Bio-Techne (1 mentions) Complete freund s adjuvant, by Merck Group (1 mentions) Hu210, by Bio-Techne (1 mentions) Picrotoxin ptx, by Merck Group (1 mentions) Enkephalin, by Bio-Techne (1 mentions) Rs baclofen, by Bio-Techne (1 mentions) N6 cyclopentyladenosine, by Bio-Techne (1 mentions) Histamine dihydrochloride, by Bio-Techne (1 mentions)

Spelling variants of this product

WIN55,212-2 (47 citations)

4 protocols using win55 212

1

Pharmacological Modulation of Signaling Pathways

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WIN55,212 (WIN: in vitro: 0.5µM; in vivo: 3mg/kg), AM251 (10µM), ZD7288 (in vitro: 0.1mM; in vivo: 15µg/animal), SB203580 (p38-inhibitor; 10µM), SP600125 (JNK-inhibitor; 10µM), JZL184 (JZL; 1µM), URB597 (URB; 1µM), gallein (10µM), anisomycin (30µM), ODQ (10µM), L-NAME (100µM), DDOA (10mM) were obtained from Tocris (Ellisville, MO). CPTIO (1mM or 10mM) was obtained from Cayman (Ann. Arbor, MI).
Maroso M., Szabo G.G., Kim H.K., Alexander A., Bui A.D., Lee S.H., Lutz B, & Soltesz I. (2016). Cannabinoid control of learning and memory through HCN channels. Neuron, 89(5), 1059-1073.
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2

Pharmacological Modulation of Pain Pathways

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HU210, WIN55212 and STZ (streptozotocin) were purchased from Tocris Bioscience (Abingdon, UK). CFA (Complete Freund’s Adjuvant) was purchased from Sigma-Aldrich (Munich, Germany). Tramadol was purchased from The Arab Pharmaceutical Manufacturing Co. Ltd. (Amman, Jordan). Morphine was purchased from Hikma Pharmaceuticals LLC (Amman, Jordan). Unless otherwise indicated, drugs were initially dissolved in ethanol (100%) to form a stock solution, and then diluted in (3% tween 20 in saline).
Alsalem M., Altarifi A., Haddad M., Azab B., Kalbouneh H., Imraish A., Saleh T, & El-Salem K. (2020). Analgesic Effects and Impairment in Locomotor Activity Induced by Cannabinoid/Opioid Combinations in Rat Models of Chronic Pain. Brain Sciences, 10(8), 523.
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3

Pharmacological Modulation of Neuroreceptors

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(RS)-Baclofen (BAC), sumatriptan succinate, [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin (DAMGO), (-)–U50488, WIN 55-212, (1R, 4R, 5S, 6R)-4-Amino-2-oxabicyclo [3.1.0] hexane-4,6-dicarboxylic acid (LY379268), histamine dihydrochloride (HA), N6-Cyclopentyladenosine (CPA), all purchased from Tocris Bioscience. Picrotoxin (PTX) purchased from Sigma Aldrich. Benzyloxy-Cyclopentyladenosine (BnOCPA) was provided by the Hamm Lab.
Manz K.M., Zepeda J.C., Zurawski Z., Hamm H.E, & Grueter B.A. (2023). SNAP25 differentially contributes to Gi/o-coupled receptor function at glutamatergic synapses in the nucleus accumbens. Frontiers in Cellular Neuroscience, 17, 1165261.
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4

Investigating CB1 Receptor Agonist Effects

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The CB1 receptor agonist, WIN [WIN 55212-2 mesylate (R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl) methyl]pyrrolol[1,2, 3 de]-1,4-benzoxazinyl]-(1-naphthalenyl) methanone)], was obtained from Tocris Biosciences (Bristol, UK) and dissolved in 50% of DMSO and 0.9% saline. Solutions were prepared at a concentration of 2 mg/ml and drug or vehicle was administered by intraperitoneal (i.p.) injection at a volume of 1 ml/kg. The drug was administered 20 min before seizure testing.
Santos V.R., Hammack R., Wicker E., N’Gouemo P, & Forcelli P.A. (2020). Divergent Effects of Systemic and Intracollicular CB Receptor Activation Against Forebrain and Hindbrain-Evoked Seizures in Rats. Frontiers in Behavioral Neuroscience, 14, 595315.
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