All reactions were conducted in oven-dried glassware in atmosphere of nitrogen. Melting points were measured with a Büchi (Flawil, Switzerland) В-520 melting point apparatus and were not corrected. Analytical thin-layer chromatography was carried out on Silufol UV-254 silica gel plates using appropriate mixtures of ethyl acetate and hexane. Compounds were visualized with short-wavelength UV light. 1H NMR and 13C NMR spectra were recorded on Bruker MSL-300 spectrometers in DMSO-d6 using TMS as an internal standard. Mass spectra were recorded using Shimadzu LCMS-2020 system (Kyoto, Japan) with electron impact (EI) ionization. All reagents and solvents were obtained from commercial sources and used without purification.
520 melting point apparatus
Manufactured by Büchi
Sourced in Switzerland
The В-520 melting point apparatus is a laboratory equipment used to determine the melting point of solid substances. It provides a precise and controlled environment for the observation and measurement of the melting process.
Automatically generated - may contain errors
Lab products found in correlation
5 protocols using 520 melting point apparatus
1
Optimized Synthesis of Nitrogen Heterocycles
2
Synthesis of Substituted Pyridines
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All reactions were carried out in oven-dried glassware in atmosphere of nitrogen. Melting points were measured with a Buchi В-520 melting point apparatus and are uncorrected. Thin-layer chromatography was carried out on Silufol UV-254 silica gel plates using an appropriate mixture of ethyl acetate and hexane. Compounds were visualized with short-wavelength UV light. 1H NMR and 13C NMR spectra were recorded on Bruker MSL-300 spectrometers in DMSO-d6 using TMS as an internal standard. Elemental analyses were obtained at Research Institute for Chemical Crop Protection (Moscow, Russia) using Carlo Erba Strumentazione 1106 analyser. Mass spectra were recorded using Shimadzu LCMS-2020 system with electron impact (EI) ionization. All and reagents and solvents were obtained from commercial sources and used without purification.
3
Analytical Characterization of Organic Compounds
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All reactions were conducted in oven-dried glassware in atmosphere of nitrogen. Melting points
were measured with a Buchi В-520 melting point apparatus and were not corrected. Analytical thinlayer chromatography was carried out on Silufol UV-254 silica gel plates using appropriate mixtures of ethyl acetate and hexane. Compounds were visualized with short-wavelength UV light. 1 H NMR and 13 C NMR spectra were recorded on Bruker MSL-300 spectrometers in DMSO-D6-d 6 using TMS as an internal standard. Mass spectra were recorded using Shimadzu LCMS-2020 system with electron-spray (ESI) ionization. All and reagents and solvents were obtained from commercial sources and used without purification.
All mass-spectroscopic measurements required for determination of ADME properties were performed using Shimadzu VP HPLC system including vacuum degasser, gradient pumps, reverse phase HPLC column, column oven and autosampler. The HPLC system was coupled with tandem mass spectrometer API 3000 (PE Sciex). The TurboIonSpray ion source was used in both positive and negative ion modes. Acquisition and analysis of the data were performed using Analyst 1.5.2 software (PE Sciex).
were measured with a Buchi В-520 melting point apparatus and were not corrected. Analytical thinlayer chromatography was carried out on Silufol UV-254 silica gel plates using appropriate mixtures of ethyl acetate and hexane. Compounds were visualized with short-wavelength UV light. 1 H NMR and 13 C NMR spectra were recorded on Bruker MSL-300 spectrometers in DMSO-D6-d 6 using TMS as an internal standard. Mass spectra were recorded using Shimadzu LCMS-2020 system with electron-spray (ESI) ionization. All and reagents and solvents were obtained from commercial sources and used without purification.
All mass-spectroscopic measurements required for determination of ADME properties were performed using Shimadzu VP HPLC system including vacuum degasser, gradient pumps, reverse phase HPLC column, column oven and autosampler. The HPLC system was coupled with tandem mass spectrometer API 3000 (PE Sciex). The TurboIonSpray ion source was used in both positive and negative ion modes. Acquisition and analysis of the data were performed using Analyst 1.5.2 software (PE Sciex).
4
Detailed Analytical Methods for Drug Characterization
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All reactions were conducted in oven-dried glassware in atmosphere of nitrogen. Melting points
were measured with a Buchi В-520 melting point apparatus and were not corrected. Analytical thin-layer chromatography was carried out on Silufol UV-254 silica gel plates using appropriate mixtures of ethyl acetate and hexane. Compounds were visualized with short-wavelength UV light.
1 H NMR and 13 C NMR spectra were recorded on Bruker MSL-300 spectrometers in DMSO-D6-d6 using TMS as an internal standard. Mass spectra were recorded using Shimadzu LCMS-2020 system with electron-spray (ESI) ionization. All and reagents and solvents were obtained from commercial sources and used without purification.
All mass-spectroscopic measurements required for determination of ADME properties were performed using Shimadzu VP HPLC system including vacuum degasser, gradient pumps, reverse phase HPLC column, column oven and autosampler. The HPLC system was coupled with tandem mass spectrometer API 3000 (PE Sciex). The TurboIonSpray ion source was used in both positive and negative ion modes. Acquisition and analysis of the data were performed using Analyst 1.5.2 software (PE Sciex).
were measured with a Buchi В-520 melting point apparatus and were not corrected. Analytical thin-layer chromatography was carried out on Silufol UV-254 silica gel plates using appropriate mixtures of ethyl acetate and hexane. Compounds were visualized with short-wavelength UV light.
1 H NMR and 13 C NMR spectra were recorded on Bruker MSL-300 spectrometers in DMSO-D6-d6 using TMS as an internal standard. Mass spectra were recorded using Shimadzu LCMS-2020 system with electron-spray (ESI) ionization. All and reagents and solvents were obtained from commercial sources and used without purification.
All mass-spectroscopic measurements required for determination of ADME properties were performed using Shimadzu VP HPLC system including vacuum degasser, gradient pumps, reverse phase HPLC column, column oven and autosampler. The HPLC system was coupled with tandem mass spectrometer API 3000 (PE Sciex). The TurboIonSpray ion source was used in both positive and negative ion modes. Acquisition and analysis of the data were performed using Analyst 1.5.2 software (PE Sciex).
5
Synthesis and Characterization of Organic Compounds
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+ Expand
All reactions were conducted in oven-dried glassware . Melting points were measured with a Buchi В-520 melting point apparatus and were not corrected. Analytical thin-layer chromatography was carried out on Silufol UV-254 silica gel plates using appropriate mixtures of ethyl acetate and hexane.
Compounds were visualized with short-wavelength UV light. 1 H NMR and 13 C NMR spectra were recorded on Bruker MSL-300 spectrometers in DMSO-D6-d6 using TMS as an internal standard. Mass spectra were recorded using Shimadzu LCMS-2020 system with electron impact (EI) ionization. All and reagents and solvents were obtained from commercial sources and used without purification.
All mass-spectroscopic measurements required for determination of ADME properties were performed using Shimadzu VP HPLC system including vacuum degasser, gradient pumps, reverse phase HPLC column, column oven and autosampler. The HPLC system was coupled with tandem mass spectrometer API 3000 (PE Sciex). The TurboIonSpray ion source was used in both positive and negative ion modes.
Acquisition and analysis of the data were performed using Analyst 1.5.2 software (PE Sciex).
Compounds were visualized with short-wavelength UV light. 1 H NMR and 13 C NMR spectra were recorded on Bruker MSL-300 spectrometers in DMSO-D6-d6 using TMS as an internal standard. Mass spectra were recorded using Shimadzu LCMS-2020 system with electron impact (EI) ionization. All and reagents and solvents were obtained from commercial sources and used without purification.
All mass-spectroscopic measurements required for determination of ADME properties were performed using Shimadzu VP HPLC system including vacuum degasser, gradient pumps, reverse phase HPLC column, column oven and autosampler. The HPLC system was coupled with tandem mass spectrometer API 3000 (PE Sciex). The TurboIonSpray ion source was used in both positive and negative ion modes.
Acquisition and analysis of the data were performed using Analyst 1.5.2 software (PE Sciex).
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