Pearlitol 25c

Mefenamic acid (SIGMA, St. Louis, MO, USA) and acetylsalicylic acid (ASA) (Lot: W004649, Glatt GmbH, Binzen, Germany) were selected as a model compound to prepare rapidly disintegrating tablets. d-mannitol (Pearlitol 25C, Roquette, Lestrem, France) and microcrystalline cellulose (Avicel PH-101, FMC bioPolymer, Philadelphia, PA, USA) were used as diluents, and croscarmellose sodium (Ac-Di-Sol, FMC bioPolymer, Philadelphia, PA, USA) was used as a disintegrant. Hydroxypropyl cellulose (HPC SL, NIPPON SODA, Tokyo, Japan) was a binder, and magnesium stearate (Peter Greven GmbH & Co, Bad Münstereifel, Germany) as a lubricant was also selected. Polycaprolactone (1639, Abifor, Zurich, Switzerland) was used for the inert 2nd layer of the triple-layer tablet. Cetyltrimethylammonium bromide (CTAB) (Merck, Kenilworth, NJ, USA) was used as a surfactant for dissolution tests.

Mefenamic acid (SIGMA, St. Louis, MO, USA) was used as a model compound to prepare rapidly disintegrating tablets. The excipients used were d-mannitol (Pearlitol 25C, Roquette, Lestrem, France) and microcrystalline cellulose (Avicel PH-101, FMC bioPolymer, Philadelphia, PA, USA) as diluents, croscarmellose sodium (Ac-Di-Sol, FMC bioPolymer, Philadelphia, PA, USA) as a disintegrant, hydroxypropyl cellulose (HPC SL, NIPPON SODA, Tokyo, Japan) as a binder, and magnesium stearate (Peter Greven GmbH & Co, Bad Münstereifel, Germany) as a lubricant. Cetyltrimethylammonium bromide (CTAB) (Merck, Kenilworth, NJ, USA) was used as a surfactant for disintegration tests and dissolution tests.