All imaging was conducted using the same General Electric 3T MR750w system and 32-channel head coil at the Alberta Children’s Hospital, Calgary, Canada. Children were scanned either while awake and watching a movie of their choice or while sleeping without sedation. Foam padding was used to minimize head motion. Prior to scanning, parents were provided with detailed information of MRI procedures and were invited to an optional practice MRI session in an MRI mock scanner to familiarize the child with the scanning environment (Thieba et al., 2018 (link)). Whole-brain diffusion weighted images were acquired in 4:03 min using single shot spin echo echo-planar imaging sequence with: 1.6 mm × 1.6 mm × 2.2 mm resolution (resampled to 0.78 mm × 0.78 mm × 2.2 mm on scanner), TR = 6,750 ms; TE = 79 ms, 30 gradient encoding directions at b = 750 s/mm2, and 5 interleaved images without diffusion encoding at b = 0 s/mm2.
3t mr750w system
Manufactured by GE Healthcare
The 3T MR750w system is a magnetic resonance imaging (MRI) system designed and manufactured by GE Healthcare. It operates at a magnetic field strength of 3 Tesla, providing high-resolution imaging capabilities. The system features a wide-bore design and advanced imaging technologies to capture detailed anatomical and functional information.
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9 protocols using 3t mr750w system
1
Pediatric Diffusion Imaging Protocol
2
Diffusion Weighted Imaging of Pediatric Brains
3
Diffusion-weighted Imaging of Pediatric Brains
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Images were acquired using a GE 3T MR750w system with a 32-channel head coil (GE, Waukesha, WI) at the Alberta Children’s Hospital in Calgary, Canada. Before image acquisition, researchers conducted acclimatization procedures with participants to improve the quality of the data acquired in such young children. Specifically, children were given time to practice in a simulated scanner such that they could get used to the size and sound of the machine. Both the simulation scanners and MRI scanners had a space rocket appearance, and the children were told that they were astronauts on a mission. A detailed description is given in a previous article [27 (link)]. Participants were scanned either while they were awake watching a movie or sleeping.
A single-shot spin echo-planar imaging sequence was used to obtain a whole-brain diffusion-weighted image, with 1.6 × 1.6 × 2.2 mm3 resolution, reconstructed to 0.78 × 0.78 × 2.2 mm. Total brain coverage had a matrix size = 256 × 256 × 54, field of view = 200 mm × 200 mm, TR = 6750 ms, TE = 79 ms (in the first year of data collection, this was the TE as set to minimum), flip angle = 90°, anterior–posterior phase encoding, 30 diffusion encoding gradient directions at b = 750 s/mm2, and five interleaved images without diffusion encoding at b = 0 s/mm2. The scan duration was 4 min and 3 s.
A single-shot spin echo-planar imaging sequence was used to obtain a whole-brain diffusion-weighted image, with 1.6 × 1.6 × 2.2 mm3 resolution, reconstructed to 0.78 × 0.78 × 2.2 mm. Total brain coverage had a matrix size = 256 × 256 × 54, field of view = 200 mm × 200 mm, TR = 6750 ms, TE = 79 ms (in the first year of data collection, this was the TE as set to minimum), flip angle = 90°, anterior–posterior phase encoding, 30 diffusion encoding gradient directions at b = 750 s/mm2, and five interleaved images without diffusion encoding at b = 0 s/mm2. The scan duration was 4 min and 3 s.
4
Diffusion-Weighted Imaging in Pediatric MRI
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MRI scans were completed on a research‐dedicated GE 3T MR750w system with a 32‐channel head coil at the Alberta Children's Hospital. Families were given reading materials to prepare children at home and were offered one or more practice sessions in an MRI simulator (Thieba et al., 2018 (link)). To minimize head motion throughout the scan, foam padding was used, and children were able to watch a movie using headphones, a projector, and a screen. Whole‐brain diffusion weighted images were acquired in 4:03 min using single shot spin echo echo‐planar imaging sequence with: 1.6 × 1.6 × 2.2 mm resolution (resampled to 0.78 × 0.78 × 2.2 mm on scanner), TR = 6750 ms; TE = 79 ms, 30 gradient encoding directions at b = 750 s/mm2, and 5 interleaved images without diffusion encoding at b = 0 s/mm2.
5
Diffusion MRI Acquisition and Analysis
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Children underwent a diffusion MRI scan on the same research-dedicated General Electric 3 T MR750w system with a 32-channel head coil at the Alberta Children's Hospital in Calgary, Canada. Diffusion tensor imaging (DTI) data were acquired using single shot spin echo echo-planar imaging sequence of 1.6 × 1.6 × 2.2 mm resolution (resampled to 0.78 × 0.78 × 2.2 mm on scanner), TR = 6750 ms; TE = 79 ms, 30 gradient encoding directions at b = 750 s/mm2, and 5 images at b = 0 s/mm2, scan time 4:03 min (See Reynolds et al., 2020 (link) for further details).
DTI images were preprocessed using ExploreDTI (Leemans, 2009 ). Raw DICOM images were converted to NIFTI format, and b-matrices were generated. Preprocessing steps included flip/permute images, correction for signal drift, Gibbs ringing correction, head motion correction, and correction for eddy current distortions. Diffusion tensor was calculated to extract fractional anisotropy (FA) values, and whole brain tractography was performed with seedpoint resolution = 2 × 2 × 2 mm3, seed FA threshold = 0.15, fiber length range = 50–500 mm, angle threshold = 30°, step size = 1.
DTI images were preprocessed using ExploreDTI (Leemans, 2009 ). Raw DICOM images were converted to NIFTI format, and b-matrices were generated. Preprocessing steps included flip/permute images, correction for signal drift, Gibbs ringing correction, head motion correction, and correction for eddy current distortions. Diffusion tensor was calculated to extract fractional anisotropy (FA) values, and whole brain tractography was performed with seedpoint resolution = 2 × 2 × 2 mm3, seed FA threshold = 0.15, fiber length range = 50–500 mm, angle threshold = 30°, step size = 1.
6
Pediatric MRI Scanning Protocol
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For all children, MRI scans were completed on a research-dedicated GE 3 T MR750w system with a 32-channel head coil at the Alberta Children’s Hospital. Families were given reading materials to prepare children at home and were offered one or more practice sessions in an MRI simulator (Thieba et al., 2018 (link)). To minimize head motion throughout the scan, foam padding was used, and children were able to watch a movie using headphones, a projector, and a screen. The MRI protocol included the acquisition of T1-weighted anatomical images (FSPGR BRAVO sequence parameters: 0.9 × 0.9 × 0.9 mm resolution, 210 axial slices, TR = 8.23 ms, TE = 3.76 ms, flip angle = 12 degrees, matrix size = 512×512, inversion time = 540 ms). During T1 acquisition, children were not sedated and were awake viewing a movie of their choice or sleeping naturally.
7
Diffusion MRI Imaging of Children
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Children underwent an MRI scan at the Alberta Children's Hospital on the research-dedicated GE 3T MR750w system with a 32-channel head coil. Children were not sedated for scanning, but families were given reading materials to prepare children at home and offered one or more practice sessions in an MRI simulator (Thieba et al., 2018) . Foam padding was used to minimize head motion, and headphones with a projector and screen allowed children to watch a movie throughout the scan. Whole-brain diffusion weighted images were acquired in 4:03 minutes using single shot spin echo echo-planar imaging sequence with: 1.6 x 1.6 x 2.2 mm resolution (resampled to 0.78 x 0.78 x 2.2mm on scanner), TR = 6750 ms; TE = 79 ms, 30 gradient encoding directions at b=750 s/mm 2 , and 5 interleaved images without diffusion encoding at b=0 s/mm 2 .
8
Pediatric Diffusion Imaging: Awake and Asleep
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All imaging was conducted using the same General Electric 3T MR750w system and 32channel head coil (GE, Waukesha, WI) at the Alberta Children's Hospital, Calgary, Canada.
Children were scanned either while awake and watching a movie, or while sleeping without sedation. Prior to scanning, parents were provided with detailed information on MRI procedures and were given the option to complete a practice MRI session in an MRI simulator to familiarize their child with the scanning environment, and/or to make use of a take home pack with information on MRI scanning (e.g., noise recordings (Thieba et al., 2018) (link)).
Whole-brain diffusion weighted images were acquired using single shot spin echo echo-planar imaging sequence with: 1.6 x 1.6 x 2.2 mm resolution (resampled on scanner to 0.78 x 0.78 x 2.2 mm), full brain coverage (matrix size: 256 x 256 x 54), FOV = 200mm x 200mm, TR = 6750 ms; TE = 79 ms, flip angle = 90˚, anterior-posterior phase encoding, 30 gradient encoding directions at b=750s/mm 2 , and five interleaved images without gradient encoding at b=0s/mm 2 , for a total acquisition time of 4:03 minutes.
Children were scanned either while awake and watching a movie, or while sleeping without sedation. Prior to scanning, parents were provided with detailed information on MRI procedures and were given the option to complete a practice MRI session in an MRI simulator to familiarize their child with the scanning environment, and/or to make use of a take home pack with information on MRI scanning (e.g., noise recordings (Thieba et al., 2018) (link)).
Whole-brain diffusion weighted images were acquired using single shot spin echo echo-planar imaging sequence with: 1.6 x 1.6 x 2.2 mm resolution (resampled on scanner to 0.78 x 0.78 x 2.2 mm), full brain coverage (matrix size: 256 x 256 x 54), FOV = 200mm x 200mm, TR = 6750 ms; TE = 79 ms, flip angle = 90˚, anterior-posterior phase encoding, 30 gradient encoding directions at b=750s/mm 2 , and five interleaved images without gradient encoding at b=0s/mm 2 , for a total acquisition time of 4:03 minutes.
9
Pediatric Brain Diffusion Imaging Protocol
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Imaging took place at the Alberta Children's Hospital on the same General Electric 3T MR750w system using a 32-channel head coil (GE, Waukesha, WI). Children were scanned while awake and watching a movie, or while sleeping without sedation.
Whole-brain diffusion weighted images were acquired using a single shot spin echo echo-planar imaging protocol, with 30 gradient encoding directions at b=750s/mm 2 and 5 images without gradient encoding (b=0s/mm 2 ). The DTI sequence was acquired with the following parameters: TR = 6750 ms, TE = 79 ms, 50 axial slices with a 2.2mm thickness (no gap), 1.6x1.6x2.2mm 3 resolution, anterior-posterior phase encoding, scan time = 4:03 minutes.
Whole-brain diffusion weighted images were acquired using a single shot spin echo echo-planar imaging protocol, with 30 gradient encoding directions at b=750s/mm 2 and 5 images without gradient encoding (b=0s/mm 2 ). The DTI sequence was acquired with the following parameters: TR = 6750 ms, TE = 79 ms, 50 axial slices with a 2.2mm thickness (no gap), 1.6x1.6x2.2mm 3 resolution, anterior-posterior phase encoding, scan time = 4:03 minutes.
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