K5-UCP3 FVB/N and K5-Akt FVB/N mice were previously generated using a bovine keratin 5 (K5) targeting construct as previously described18 (link),33 (link),51 (link), maintained as hemizygous breeder colonies, and crossed K5-UCP3×K5-Akt to produce bitransgenic K5-UCP3/K5-Akt mice and littermate controls. FVB/N mice were purchased from Jackson Laboratories (Bar Harbor, ME). Tg.AC mice were purchased from Taconic (Hudson, NY). Unless otherwise indicated, all experiments were performed using sex matched adult, 6–8 week old mice. All animal husbandry and experiments were carried out in strict accordance to guidelines defined by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) and approved by the institutional animal research committees at The University of Texas at Austin and UT-MD Anderson, Science Park Research Division.
Tg ac mice
Manufactured by Taconic Biosciences
The Tg.AC mouse is a transgenic mouse model developed by Taconic Biosciences. It carries a transgene that can be used for the study of tumor development and skin carcinogenesis. The core function of the Tg.AC mouse is to serve as a tool for researchers in the field of oncology and skin biology.
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Lab products found in correlation
3 protocols using tg ac mice
1
Generating Transgenic Mice Models
2
Transgenic Mouse Models for Oncogenesis
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All animal experiments were approved by the University of South Florida Institutional Animal Care and Use Committee. Mice were housed in pathogen-free facilities. Tg.AC mice described previously (Tepper et al., 1990 (link)) were obtained from Taconic. S100A9Tg mice on FVB/N background (Cheng et al., 2008 (link)) and S100A9KO mice on C57BL/6 background (Manitz et al., 2003 (link)) were described previously. BALB/c, C57BL/6, and FVB/N mice were obtained from the National Cancer Institute, and OT-1 mice were obtained from the Jackson Laboratory. In S100A9Tg;Tg.AC bitransgenic mice, the presence of S100A9-IRES-GFP transgene was verified by the expression of GFP in leukocytes from peripheral blood, and the v-h-ras transgene was detected by genomic PCR for the SV40 sequences. In some experiments, S100A9Tg mice on C57BL/6 background were used after backcrossing S100A9Tg FVB/N mice with C57BL/6 mice for nine generations.
3
Transgenic Mice for Skin Research
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K5-UCP3 FVB/N and K5-Akt FVB/N mice were previously generated using a bovine keratin 5 (K5) targeting construct as previously described18 (link)33 (link)51 (link), maintained as hemizygous breeder colonies, and crossed K5-UCP3 × K5-Akt to produce bitransgenic K5-UCP3/K5-Akt mice and littermate controls. FVB/N mice were purchased from Jackson Laboratories (Bar Harbor, ME). Tg.AC mice were purchased from Taconic (Hudson, NY). Unless otherwise indicated, all experiments were performed using sex matched adult, 6–8-week old mice. All animal husbandry and experiments were carried out in strict accordance to guidelines defined by the Association for Assessment and Accreditation of Laboratory Animal Care and approved by the institutional animal research committees at The University of Texas at Austin and UT-MD Anderson, Science Park Research Division.
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