U plex biomarker 1

Manufactured by Mesoscale

The U-Plex Biomarker-1 is an analytical instrument designed for the detection and quantification of multiple biomarkers simultaneously. It utilizes multiplex technology to enable the measurement of a panel of analytes from a single sample. The core function of the U-Plex Biomarker-1 is to provide high-throughput, sensitive, and accurate biomarker analysis.

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Lab products found in correlation

Element dc veterinary chemistry analyzer, by Fujifilm (2 mentions) Quantichrom urea assay kit, by BioAssay Systems (1 mentions) Quantichrom urea assay kit, by Horiba (1 mentions)

Close spelling variants of this product

U-PLEX Biomarker Group 1 U-PLEX Biomarker group 1 mouse Assay U-Plex Biomarker Group 1 (mouse) kit U-PLEX Biomarker Group 1 kit U-PLEX Biomarker Group 1 (human) Multiplex Assays U-PLEX

2 protocols using u plex biomarker 1

Multianalyte Kidney Injury Evaluation

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BUN and serum and urine creatinine were measured using a BioAssay Systems QuantiChrom Urea Assay Kit Cat: (DIUR-500) (BioAssay Systems, Hayward, California) and Pointe Scientific Creatinine (Enzymatic) Reagent Kit (Cat: C7548-480) (Pointe Scientific Inc, Canton, Michigan). Because of hemolysis, the 12-month SCr was determined using the Element DC Veterinary Chemistry Analyzer (Fujifilm, Serial # 73110474, Stamford, Connecticut [supported by Heska, Des Moines, Iowa]), using the Comparative Pathology Core at UC. Neutrophil gelatinase-associated lipocalin (NGAL) was measured by enzyme-linked immunosorbent assay (ELISA) (R and D Systems, Minneapolis, Minnesota), following the manufacturer's instructions (detection level: 8.8 pg/ml). Cytokines were measured by a customized U-Plex Biomarker-1 (Cat # K15069L-S, Meso Scale Discovery, Rockville, Maryland), following the manufacturer's instructions. Plasma renin was quantified using the Renin 1 Mouse ELISA Kit (Cat # EMREN1, Invitrogen, Carlsbad, California) and performed according to the manufacturer's instructions.

Soranno D.E., Kirkbride-Romeo L., Wennersten S.A., Ding K., Cavasin M.A., Baker P., Altmann C., Bagchi R.A., Haefner K.R., Steinkühler C., Montford J.R., Keith B., Gist K.M., McKinsey T.A, & Faubel S. (2021). Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition. JACC: Basic to Translational Science, 6(2), 119-133.

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Biochemical and Cytokine Assays

Cited 1 time

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BUN and SCr were assayed using a BioAssay Systems QuantiChrom™ Urea Assay Kit Cat: (DIUR-500) and Pointe Scientific Creatinine (Enzymatic) Reagent Kit (Cat: C7548-480) for the 24-h inclusion time point. Due to extensive hemolysis in the male 12-month groups, 12-month SCr in both sexes was measured using the Element DC Veterinary Chemistry Analyzer (Serial #:73110474, Manufacturer: Fujifilm, Stamford, CT, supported by Heska, Des Moines, IA) via the Comparative Pathology Core at UC Denver. Cytokines were measured by a customized U-Plex Biomarker-1 (Cat#: K15069L-S, Meso Scale Discovery, Rockville, MD) following the manufacturer's instructions as previously reported^{21 (link)}.

Soranno D.E., Baker P I.I., Kirkbride-Romeo L., Wennersten S.A., Ding K., Keith B., Cavasin M.A., Altmann C., Bagchi R.A., Haefner K.R., Montford J., Gist K.M., Vergnes L., Reue K., He Z., Elajaili H., Okamura K., Nozik E., McKinsey T.A, & Faubel S. (2022). Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia–reperfusion acute kidney injury. Scientific Reports, 12, 643.

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