Clinimix e

Manufactured by Baxter

Sourced in United States

Clinimix E is a multi-chamber bag that contains a balanced mixture of amino acids, electrolytes, and dextrose. It is designed for intravenous administration to provide parenteral nutrition to patients.

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Lab products found in correlation

Intralipid, by Fresenius (2 mentions)

5 protocols using clinimix e

Enteral vs Parenteral Nutrition in Neonates

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As previously described, the EN control group received a swine replacement formula (LitterLife; Merrick’s Inc, Middleton, WI). EN was provided via a duodenal catheter at a rate of 260 mL/kg/d with 25 g/kg of lactose, 12.4 g/kg of protein, and 5 g/kg of fat supplemented with electrolytes, trace minerals, and vitamins for a total of 187 kcal/kg/d (Figure 1). PN piglets received a commercially available PN preparation (Clinimix E; Baxter, Deerfield, IL) continuously via a jugular venous catheter, which provided fluids at 260 mL/kg/d with 26 g/kg of dextrose, 11.05 g/kg of protein, and 5 g/kg of fat along with electrolytes, trace minerals, and vitamins for a total of 182 kcal/kg/d (Figure 1).
The PN and EN were placed in nutrition bags (EVA, product code 66050; Medtec Medical, Buffalo Grove, IL) and replaced every 12 hours. Isocaloric nutrition was provided to all animals for approximately 2 weeks as previously published.^{27 (link)} Another group of animals received OA delivered enterally in addition to PN.

Jain A.K., Sharma A., Arora S., Blomenkamp K., Jun I.C., Luong R., Westrich D.J., Mittal A., Buchanan P.M., Guzman M.A., Long J., Neuschwander-Tetri B.A, & Teckman J. (2016). Preserved Gut Microbial Diversity Accompanies Upregulation of TGR5 and Hepatobiliary Transporters in Bile Acid–Treated Animals Receiving Parenteral Nutrition. JPEN. Journal of parenteral and enteral nutrition, 41(2), 198-207.

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Enteral vs. Parenteral Nutrition Protocol

Cited 1 time

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Throughout the experimental period, isocaloric nutrition was provided to all animals. As published [3 ,8 (link),22 (link)], the enteral nutrition (EN) group received the swine replacement formula LitterLife, Merrick’s Inc., WI, USA via the duodenal catheter. TPN was delivered using the commercially available Parenteral Nutrition preparation (Clinimix E, Baxter, IL, USA) and Intralipid (Fresenius Kabi, Germany) via the jugular catheter.

Samaddar A., van Nispen J., Armstrong A., Song E., Voigt M., Murali V., Krebs J., Manithody C., Denton C., Ericsson A.C, & Jain A.K. (2022). Lower systemic inflammation is associated with gut firmicutes dominance and reduced liver injury in a novel ambulatory model of parenteral nutrition. Annals of Medicine, 54(1), 1701-1713.

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Continuous Parenteral Nutrition in Animal Models

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As previously described, all animals received a commercially available PN preparation continuously (Clinimix E; Baxter, Deerfield, IL, USA) via the jugular venous catheter. This provided fluids at 260 mL/kg body weight/day with 26 g/kg dextrose, 11.05 g/kg protein, and 5 g/kg fat along with electrolytes, trace minerals, and vitamins for a total of 182 kcal/kg body weight/day (Table 1). The PN was placed in nutrition bags (Medtec Medical, EVA, Product Code 66050) and replaced every 12 hours. Isocaloric nutrition^{33 (link)} was provided to all animals for a period of approximately 2 weeks as previously published.^{3 (link),16 (link)}

Villalona G., Price A., Blomenkamp K., Manithody C., Saxena S., Ratchford T., Westrich M., Kakarla V., Pochampally S., Phillips W., Heafner N., Korremla N., Greenspon J., Guzman M.A, & Jain A.K. (2018). No Gut No Gain! Enteral Bile Acid Treatment Preserves Gut Growth but Not Parenteral Nutrition–Associated Liver Injury in a Novel Extensive Short Bowel Animal Model. JPEN. Journal of parenteral and enteral nutrition, 42(8), 1238-1251.

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Isocaloric and Isonitrogenous Nutrition in Piglets

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Isocaloric and isonitrogenous nutrition was provided to all animals for a period of approximately 3 weeks. The EN group received the swine replacement formula LitterLife (Merrick's Inc). Enteral nutrition was delivered via the duodenal catheter at a rate of 260 mL kg–1 d–1 with 25 g/kg lactose, 12.4 g/kg protein, and 5 g/kg fat along with electrolytes, trace minerals, and vitamins, for a total of 187 kcal kg–1 d–1.
Total parenteral nutrition piglets received the commercially available parenteral nutrition preparation (Clinimix E; Baxter, IL, USA;) via the jugular catheter. This provided fluids at 260 mL kg–1 d–1 with 26 g/kg dextrose, 11.05 g/kg protein, and 5 g/kg fat along with electrolytes, trace minerals, and vitamins, for a total of 182 kcal kg–1 d–1 via the jugular catheter.
The TPN or EN was placed in nutrition bags (EVA, product code 66050; Medtec Medical) with nutritional constituents as seen in table 2. All nutrition bags were replaced every 12 hours using aseptic precautions.

Price A., Blomenkamp K., Manithody C., Saxena S., Abraham S.M., Greenspon J., Villalona G.A, & Jain A.K. (2018). Developing a novel ambulatory total parenteral nutrition dependent short bowel syndrome animal model. The Journal of surgical research, 234, 13-19.

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Parenteral Nutrition Comparison in Piglets

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As published previously, the EN control group received a swine replacement formula (LitterLife, Merrick’s Inc., WI) at a rate of 260ml/kg/day with 25 g/kg lactose, 12.4 g/kg protein and 5g/kg fat supplemented with electrolytes, trace minerals and vitamins for a total of 187 kcal/kg/day (18 (link)). Piglets on TPN were continuously administered a commercial parenteral nutrition preparation (Clinimix E; Baxter, Deerfield, IL, USA) supplemented with Intralipid (Fresenius Kabi, Hersfeld, Germany), at 260 mL/kg/day. This nutrition provided a cumulative 182 kcal/kg/day, consisting of 26 g/kg dextrose, 11.05 g/kg protein, and 5 g/kg fat in the form of soybean oil consisting of linoleic, oleic, and palmitic acids, as well as electrolytes, trace minerals, and vitamins (3 (link), 18 (link)). Isocaloric nutrition (19 (link)) was provided to all animals for a period of 2 weeks as described previously (3 (link),18 (link)).

Song E., Nagarapu A., van Nispen J., Armstrong A., Manithody C., Murali V., Voigt M., Samaddar A., Hutchinson C., Jain S., Roenker J., Krebs J, & Jain A.K. (2022). Carbamazepine Mitigates Total Parenteral Nutrition Associated Liver Disease in a Novel Ambulatory Piglet Model. JPEN. Journal of parenteral and enteral nutrition, 46(6), 1384-1392.

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