Ondansetron ond

Manufactured by Bio-Techne

Sourced in United Kingdom

Ondansetron (OND) is a chemical compound that is commonly used as a laboratory reagent. It is a selective 5-HT3 receptor antagonist, which means it binds to and blocks the 5-HT3 receptor, a type of serotonin receptor. Ondansetron is often used in research studies involving serotonin signaling and its effects on various biological processes.

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Ondansetron

2 protocols using ondansetron ond

Intracerebral Drug Injections in DMH and DRt

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Solutions for intracerebral drug injections in the DMH and DRt were prepared with sterilized saline 0.9% (Unither, Amiens, France; pH 7.2) except for LIDO, which was acquired as a solution. Each injection had a volume of 0.5 μL and contained either 50 nmol of GLU (Merck, Darmstadt, Germany), LIDO 4% (OrionPharma, Espoo, Finland), 1 nmol of GAL (Tocris, Bristol, UK) or 0.3 nmol ondansetron (OND) (Tocris). In the results section, the behavioural and electrophysiological changes induced by a drug were considered at the time point of maximum effect of each drug: 1 min for GLU, 20 min for GAL and LIDO and 30 min for OND.

Amorim D., Viisanen H., Wei H., Almeida A., Pertovaara A, & Pinto-Ribeiro F. (2015). Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. PLoS ONE, 10(11), e0142919.

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Serotonin Receptor Role in Masseter Muscle Activity

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Animals were prepared surgically as noted above for neural recording. Masseter muscle EMG activity was recorded from paired wire electrodes (0.12 mm diameter, 5 mm interpolar distance) implanted ~1 mm into the central portion of the masseter muscle ipsilateral to the TMJ cannula. The experimental design to test for 5HT3R involvement consisted of: 1) initial intra-TMJ injection of PBS, 2) intra-TMJ injection of ATP alone, 3) ondansetron (OND, 1 mM, 30 μl, pH = 7.4 in PBS, Tocris, Ellisville, MO) applied topically to the Vc/C_1–2 surface 10 min prior to subsequent intra-TMJ injection of ATP, 4) intra-TMJ injection of ATP 30 min after OND. Intra-TMJ injections of ATP were separated by 20 min intervals. Masseter muscle EMG activity was sampled at 1000 Hz, amplified, filtered (300–3000 Hz), displayed and stored for analyses offline. EMG activity was assessed in sham rats (n = 12) and in FS-conditioned rats (n = 11).

Okamoto K., Katagiri A., Rahman M., Thompson R, & Bereiter D.A. (2015). Inhibition of temporomandibular joint input to medullary dorsal horn neurons by 5HT3 receptor antagonist in female rats. Neuroscience, 299, 35-44.

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